Abstract
One hundred microlitres (0.1 ml) of N-butyl cyanoacrylate adhesive was injected into the inferior cannaliculus of 8 patients with dry eye. The adhesive induced total (upper and lower) cannalicular occlusion in each patient which has not resolved to date (mean follow-up 15.2 months, range 11-19 months). Complications were minor and not specific to use of this adhesive. It is hoped that its ultimate reversibility will make the technique suitable for younger patients with dry eye.
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Information Statement from American Academy of Ophthalmology. Punctal occlusion for the dry eye. Ophthalmology 1992;99:639–40.
Denffer HV, Dressier J, Pabst HW . Lacrimal dacryoscintigraphy. Sem Nucl Med 1984;14:8–15.
Foulds WS . Intra-cannalicular gelatin implants in the treatment of keratoconjunctivitis sicca. Br J Ophthalmol 1961;45:625–7.
Freeman JMM . The punctum plug: evaluation of a new treatment for the dry eye. Trans Am Acad Ophthalmol Otolaryngol 1975;79:874–9.
Dohlman CH . Punctal occlusion in keratoconjunctivitis sicca. Ophthalmology 1978;85:1277–81.
Tuberville AW, Frederick WR, Wood TO . Punctal occlusion in tear deficiency syndromes. Ophthalmology 1982;89:1170–2.
Knapp ME, Frueh BR, Nelson CC, Musch DC . A comparison of two methods of punctal occlusion. Am J Ophthalmol 1989:108:315–8.
Refojo MF, Dohlman CH, Ahmad B, Carroll JM, Allen JC . Evaluation of adhesives for corneal surgery. Arch Ophthalmol 1968;80:645–56.
Schimek RA, Ballow GS . Eastman 910 Monomer for plastic lid procedures. Am J Ophthalmol 1966;62:953–5.
Refojo MF, Dohlman CH, Koliopoulos J . Adhesives in ophthalmology: a review. Surv Ophthamol 1971;15:217–36.
Streit S, Ackerman J, Kanarek I . Cyanoacrylate. Ann Ophthalmol 1981;13:315–6.
Leahey AB, Gottsh JD, Stark WJ . Clinical experience with N-butyl-cyanoacrylate (Nexacryl) tissue adhesive. Ophthalmology 1993;100:173–80.
Folk JC, Dreyer RF . Cyanoacrylate adhesive in retinal detachment surgery. Am J Ophthalmol 1986;101:486–7.
Tse DT . Cyanoacrylate tissue adhesives in securing orbital implants. Ophthalmic Surg 1986;17:577–80.
Diamond JP . Temporary tarsorrhaphy with cyanoacrylate adhesive for seventh nerve palsy. Lancet 1990;335:–1039.
DeGuillebon H, Zauberman H, Refojo MF . Cyanoacrylate adhesive: use in the removal of lens and foreign particles from the vitreous cavity. Arch Ophthalmol 1972;87:407–10.
Patten JT . Punctal occlusion with N-butyl-cyanoacry-late tissue adhesive. Ophthalmic Surg 1976;7:24–6.
Carlson AN, Wilhelmus KR . Giant papillary conjunctivitis associated with cyanoacrylate glue. Am J Ophthalmol 1987;104:437–78.
Belsito DV . Contact dermatitis to ethyl cyanoacrylate containing glue. Contact Dermatitis 1987;17:234–6.
Leahey AB, Gottsch JD . Symblepharon formation with cyanoacrylate adhesive. Arch Ophthalmol 1993;111:168.
Allaforr RM . Most cyanoacrylate super-glues should be removed promptly [letter]. Ophthalmic Surg 1987;18:156.
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Diamond, J., Morgan, J., Virjee, J. et al. Cannalicular occlusion with cyanoacrylate adhesive: A new treatment for the dry eye. Eye 9, 126–129 (1995). https://doi.org/10.1038/eye.1995.21
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DOI: https://doi.org/10.1038/eye.1995.21