Collections

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    It has been widely accepted that genome analysis has great potential to explain the causes of diseases and to eventually increase our quality of life. However, the current success is only the first step to achieving genuine future genome medicine. More evidence is still needed to support the clinical translation of the genomics studies. To overcome current hurdles and move one step toward the next generation of precision medicine, more research and evidence will be required. In this special issue of EMM, we present a collection of review articles on cutting edge topics in genomics and genome medicine.

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    Protein acetylation is one of the major post-translational modification that regulates cellular proteins to modify various molecular pathways. Recently, increasing knowledge of acetyltransferases and the molecular consequences of their actions are revealing the importance of acetylation in various human diseases from developmental disorders to cancer; thus, the need for an integrated understanding of the field is rising. This special issue on Experimental & Molecular Medicine presents reviews from each leader to introduce the field of protein acetylation.

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    Beyond the aerobic glycolysis proposed by Otto Warburg in the 1920s, our understanding of cancer metabolism has greatly evolved with the identification of new metabolic pathways with their potential roles and regulatory mechanisms in cancer. Uncovering the extensive network of cancer metabolism during last decades has been enormously accelerated by recent advances in cutting-edge technologies such as multi-omics and 13C metabolic flux analysis (13C-MFA). In this special issue of cancer metabolism, we invited four review articles highlighting the expanding features of cancer metabolism, covering from technological aspects of cancer metabolism research with a practical guide for using 13C-MFA to emerging roles of new metabolic pathways involving vitamin D and non-metabolic functions of metabolic enzymes.

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    During the last century, our understanding of key mechanisms of synapse and neural circuit development has greatly expanded on multiple levels in parallel with advances in our understanding of molecular and cellular aspects of various neuron and synapse types. Experimental & Molecular Medicine's 2018 Special Issue, “Synapse Assembly, Neural Circuit Development, and Brain Disorders”, discusses how synaptic proteins contribute to various aspects of synapse assembly—and by extension, neural circuit assembly.

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    We share our bodies with microbiota whose cell count vastly outnumbers ours own. During last decades, development of the DNA-based sequencing methods has deepened our understanding of microbiota. Experimental & Molecular Medicine's third special issue in this year "The microbiota in the chronic inflammation and autoimmunity" discusses how intestinal epithelial cells modulate interactions between microbial habitants and gut, and how dysbiosis is linked to chronic inflammation and autoimmune diseases. Each of the three specially-invited review articles provides a current overview and perspectives for future studies about microbiota.

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    Currently, there are more than 58 antibodies clinically available for the treatment of various diseases including cancer, chronic inflammation, and infection. In 2016, eight antibodies were newly approved, and the annual number of antibodies approved has been increasing for the past decade. This special feature of Experimental & Molecular Medicine presents reviews and original articles focusing on therapeutic antibodies and biopharmaceuticals.

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    Obesity is a major risk factor for various metabolic diseases including type 2 diabetes, hyperlipidemia, cardiovascular diseases and certain types of cancer. Over the last several decades, mounting evidence suggests the importance of inter-organ metabolic communication and genetic and environmental factors on the progress of obesity as well as its associated metabolic syndrome. In this special issue, 6 review articles deal with recent findings on the crosstalk between metabolic organs in the regulation of energy homeostasis and the etiology of obesity. Also, recent advances in genetic and epigenetic mechanism involved in the molecular pathophysiology of metabolic disease are discussed.

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    Studies of neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and Amyotrophic Lateral Sclerosis (ALS) are becoming increasingly important in this rapidly growing population of ageing. This special issue, titled “Neurodegenerative diseases and their therapeutic approaches”, discusses the underlying pathogenic mechanisms and therapeutic implications for AD and other age-associated neurodegenerative disorders, with 5 specially-invited review articles. Each review provides readers an current overview of the researches and deep insights and perspectives on future studies on AD and related neurodegenerative disorders.

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    It has been 50 years since Michael Anthony Epstein and Yvonne Barr discovered Epstein-Barr Virus (EBV) particles in cell lines cultured from tumor tissue from a Burkitt lymphoma. Since the initial discovery of the virus, more than 20,000 scientific papers on the characteristics, functions and oncogenic mechanisms of viral genes, the spectrum of EBV-associated diseases, and treatment of patients have been published. Experimental & Molecular Medicine contains six review articles that provide an overview of our current understanding of Epstein-Barr virology and oncogenesis and of EBV-associated neoplasm.