Abstract
Objectives:
To investigate possible associations between maternal diet during pregnancy and fetal growth.
Method:
Factor analysis was used to explore dietary patterns among pregnant women. The association between maternal dietary patterns and fetal growth (in terms of small for gestational age, SGA) was investigated by logistic regression. Prospective cohort study, including information on 44 612 women in Denmark.
Results:
Two major dietary patterns were defined: the first pattern was characterized by red and processed meat, high-fat dairy, and the second pattern was characterized by intake of vegetables, fruits, poultry and fish. Women were classified into three classes according to their diet: the first class had high intake of foods of the first dietary pattern, and was classified as ‘the Western diet’, the second class preferred foods of the second pattern and was classified as the ‘Health Conscious’; and the third one had eaten foods of both patterns, and was classified as the ‘Intermediate’. The odds ratio of having a small for gestational-age infant (with a birth weight below the 2.5th percentile for gestational age and gender) was 0.74 (95% CI 0.64–0.86) for women in the Health Conscious class compared with women in the Western Diet class. The analyses were adjusted for parity, maternal smoking, age, height, pre-pregnancy weight and father's height.
Conclusions:
Our results indicated that a diet in pregnancy, based on red and processed meat and high-fat diary, was associated with increased risk for SGA. Further studies are warranted to identify specific macro-, or micronutrients that may be underlying these associations.
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References
Ahlgren M, Sorensen T, Wohlfahrt J, Haflidadottir A, Holst C, Melbye M (2003). Birth weight and risk of breast cancer in a cohort of 106,504 women. Int J Cancer 107, 997–1000.
Barker DJ (1994). Mothers, babies, and disease in later life. BMJ Publishing Group: London.
Cuco G, Fernandez-Ballart J, Sala J, Viladrich C, Iranzo R, Vila J et al. (2006). Dietary patterns and associated lifestyles in preconception, pregnancy and postpartum. Eur J Clin Nutr 60, 364–371.
Dixon LB, Balder HF, Virtanen MJ, Rashidkhani B, Mannisto S, Krogh V et al. (2004). Dietary patterns associated with colon and rectal cancer: results from the Dietary Patterns and Cancer (DIETSCAN) Project. Am J Clin Nutr 80, 1003–1011.
Elias SL, Innis SM (2001). Infant plasma trans, n-6 and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. Am J Clin Nutr 73, 807–814.
Fung T, Hu FB, Fuchs C, Giovannucci E, Hunter DJ, Stampfer MJ et al. (2003). Major dietary patterns and the risk of colorectal cancer in women. Arch Intern Med 163, 309–314.
Fung TT, Stampfer MJ, Manson JE, Rexrode KM, Willett WC, Hu FB (2004). Prospective study of major dietary patterns and stroke risk in women. Stroke 35, 2014–2019.
Gittelsohn J, Wolever TM, Harris SB, Harris-Giraldo R, Hanley AJ, Zinman B (1998). Specific patterns of food consumption and preparation are associated with diabetes and obesity in a native Canadian community. J Nutr 128, 541–547.
Godfrey K, Robinson S, Barker DJ, Osmond C, Cox V (1996). Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. BMJ 312, 410–414.
Hennekens CH, Buring JE (1987). Epidemiology in Medicine. Little, Brown and Company: Boston.
Hu FB, Rimm E, Smith-Warner SA, Feskanich D, Stampfer MJ, Ascherio A et al. (1999). Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire [see comments]. Am J Clin Nutr 69, 243–249.
Koletzko B (1992). Trans fatty acids may impair biosynthesis of long-chain polyunsaturates and growth in man. Acta Paediatr 81, 302–306.
Lagiou P, Tamimi RM, Mucci LA, Adami HO, Hsieh CC, Trichopoulos D (2004). Diet during pregnancy in relation to maternal weight gain and birth size. Eur J Clin Nutr 58, 231–237.
Larque E, Zamora S, Gil A (2001). Dietary trans fatty acids in early life: a review. Early Hum Dev 65 (Suppl), S31–S41.
Lenders CM, Hediger ML, Scholl TO, Khoo CS, Slap GB, Stallings VA (1994). Effect of high-sugar intake by low-income pregnant adolescents on infant birth weight. J Adolesc Health 15, 596–602.
Leon D, Ben-Shlomo Y (1997). Pre-adult influences on cardiovascular disease and cancer. In: ‘A Life-course Approach to Chronic Disease and Cancer’ (D. Kuh and Y. Ben-Shlomo Eds.). Oxford University Press: Oxford, UK. pp. 45–77.
Mardia KV, Kent JM, Bibby JM (1980). Multivariate analysis. London: Academic Press.
Marsal K, Persson PH, Larsen T, Lilja H, Selbing A, Sultan B (1996). Intrauterine growth curves based on ultrasonically estimated foetal weights. Acta Paediatr 85, 843–848.
Mathews F, Yudkin P, Neil A (1999). Influence of maternal nutrition on outcome of pregnancy: prospective cohort study. BMJ 319, 339–343.
Mikkelsen TB, Osler M, Olsen SF (2006). Validity of protein, retinol, folic acid and n-3 fatty acid intakes estimated from the food-frequency questionnaire used in the Danish National Birth Cohort. Public Health Nutr 9, 771–778.
Mikkelsen TB, Osler M, Orozova-Bekkevold I, Knudsen VK, Olsen SF (2006). Association between fruit and vegetable consumption and birth weight: a prospective study among 43,585 Danish women. Scand J Publ Health 21, 76–86.
Moore VM, Davies MJ, Willson KJ, Worsley A, Robinson JS (2004). Dietary composition of pregnant women is related to size of the baby at birth. J Nutr 134, 1820–1826.
Newby PK, Muller D, Hallfrisch J, Andres R, Tucker KL (2004). Food patterns measured by factor analysis and anthropometric changes in adults. Am J Clin Nutr 80, 504–513.
Nordiska Ministerrådet 1996. Nordiska Näringsrekommendationer 1996. Nordiska Ministerrådet: Köbenhamn.
Olsen J, Melbye M, Olsen SF, Sorensen TI, Aaby P, Andersen AM et al. (2001). The Danish National Birth Cohort – its background, structure and aim. Scand J Public Health 29, 300–307.
Olsen SF, Secher NJ (2002). Low consumption of seafood in early pregnancy as a risk factor for preterm delivery: prospective cohort study. BMJ 324, 447.
Ong KK, Ahmed ML, Emmett PM, Preece MA, Dunger DB (2000). Association between postnatal catch-up growth and obesity in childhood: prospective cohort study. BMJ 320, 967–971.
Osler M, Heitmann BL, Gerdes LU, Jorgensen LM, Schroll M (2001). Dietary patterns and mortality in Danish men and women: a prospective observational study. Br J Nutr 85, 219–225.
Osler M, Helms Andreasen A, Heitmann B, Hoidrup S, Gerdes U, Morch Jorgensen L et al. (2002). Food intake patterns and risk of coronary heart disease: a prospective cohort study examining the use of traditional scoring techniques. Eur J Clin Nutr 56, 568–574.
Rao S, Yajnik CS, Kanade A, Fall CH, Margetts BM, Jackson AA et al. (2001). Intake of micronutrient-rich foods in rural Indian mothers is associated with the size of their babies at birth: Pune Maternal Nutrition Study. J Nutr 131, 1217–1224.
Rogers I, Emmett P, Ness A, Golding J (2004). Maternal fish intake in late pregnancy and the frequency of low birth weight and intrauterine growth retardation in a cohort of British infants. J Epidemiol Community Health 58, 486–492.
Schulze MB, Hoffmann K, Kroke A, Boeing H (2003). Risk of hypertension among women in the EPIC-Potsdam Study: comparison of relative risk estimates for exploratory and hypothesis-oriented dietary patterns. Am J Epidemiol 158, 365–373.
Schwartz R (1990). Hyperinsulinemia and macrosomia. N Engl J Med 323, 340–342.
Shiell AW, Campbell DM, Hall MH, Barker DJ (2000). Diet in late pregnancy and glucose-insulin metabolism of the offspring 40 years later. BJOG 107, 890–895.
Sieri S, Krogh V, Pala V, Muti P, Micheli A, Evangelista A et al. (2004). Dietary patterns and risk of breast cancer in the ORDET cohort. Cancer Epidemiol Biomarkers Prev 13, 567–572.
Signorello LB, Trichopoulos D (1998). Perinatal determinants of adult cardiovascular disease and cancer. Scand J Soc Med 26, 161–165.
Slattery ML, Boucher KM, Caan BJ, Potter JD, Ma KN (1998). Eating patterns and risk of colon cancer. Am J Epidemiol 148, 4–16.
Terry P, Suzuki R, Hu FB, Wolk A (2001). A prospective study of major dietary patterns and the risk of breast cancer. Cancer Epidemiol Biomarkers Prev 10, 1281–1285.
Togo P, Osler M, Sorensen TI, Heitmann BL (2004). A longitudinal study of food intake patterns and obesity in adult Danish men and women. Int J Obes Relat Metab Disord 28, 583–593.
Wolff CB, Wolff HK (1995). Maternal eating patterns and birth weight of Mexican American infants. Nutr Health 10, 121–134.
Zhang C, Schulze MB, Solomon CG, Hu FB (2006). A prospective study of dietary patterns, meat intake and the risk of gestational diabetes mellitus. Diabetologia 49, 2604–2613.
Acknowledgements
We thank Mr Kenn S Nielsen for the technical and data management support and the managerial team of the Danish National Birth Cohort, which consisted of: Jørn Olsen (Chair), Mads Melbye, Anne Marie Nybo Andersen, Sjurdur F Olsen, Thorkild IA Sørensen and Peter Aabye. Financial support for the Danish National Birth Cohort was obtained from the March of Dimes Birth Defects Foundation, the Danish National Research Foundation, the European Union (QLK1-2000-00083), the Pharmacy Foundation, the Egmont Foundation, the Augustinus Foundation and the Health Foundation.
Sponsorship: The March of Dimes Birth Defects Foundation, the Danish National Research Foundation, the European Union (QLK1-2000-00083), the Pharmacy Foundation, the Egmont Foundation, the Augustinus Foundation and the Health Foundation.
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Knudsen, V., Orozova-Bekkevold, I., Mikkelsen, T. et al. Major dietary patterns in pregnancy and fetal growth. Eur J Clin Nutr 62, 463–470 (2008). https://doi.org/10.1038/sj.ejcn.1602745
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DOI: https://doi.org/10.1038/sj.ejcn.1602745
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