The growth factor TGF-ß1 is located inside a protein cage, and is thought to be released by force applied through integrin proteins. A structure of TGF-ß1 in complex with integrin αVß6 sheds light on the uncaging process. See Article p.55
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography
EJNMMI Research Open Access 12 October 2021
-
PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the “Cancer Integrin” αvβ6 with Ga-68-Trivehexin
European Journal of Nuclear Medicine and Molecular Imaging Open Access 24 September 2021
-
Tracking a TGF-β activator in vivo: sensitive PET imaging of αvβ8-integrin with the Ga-68-labeled cyclic RGD octapeptide trimer Ga-68-Triveoctin
EJNMMI Research Open Access 31 October 2020
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Robertson, I. B. & Rifkin, D. B. Cytokine Growth Factor Rev. 24, 355–372 (2013).
Dong, X. et al. Nature 542, 55–59 (2017).
Mas-Moruno, C. et al. Angew. Chem. Int. Edn 55, 7048–7067 (2016).
Munger, J. S. et al. Cell 96, 319–328 (1999).
Yang, Z. et al. J. Cell Biol. 176, 787–793 (2007).
Shi, M. et al. Nature 474, 343–349 (2011).
Kong, F., Garcia, A. J., Mould, A. P., Humphries, M. J. & Zhu, C. J. Cell Biol. 185, 1275–1284 (2009).
Wang, X. & Ha, T. Science 340, 991–994 (2013).
Pankov, R. et al. J. Cell Biol. 148, 1075–1090 (2000).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Ha, T. Growth factor rattled out of its cage. Nature 542, 40–41 (2017). https://doi.org/10.1038/nature21119
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature21119
This article is cited by
-
PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the “Cancer Integrin” αvβ6 with Ga-68-Trivehexin
European Journal of Nuclear Medicine and Molecular Imaging (2022)
-
There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography
EJNMMI Research (2021)
-
Tracking a TGF-β activator in vivo: sensitive PET imaging of αvβ8-integrin with the Ga-68-labeled cyclic RGD octapeptide trimer Ga-68-Triveoctin
EJNMMI Research (2020)
-
Intraoperatives molekulares Bioimaging von Kopf-Hals-Karzinomen
Der MKG-Chirurg (2018)
