Abstract
A spinal pattern generator controls the ejaculatory response. Activation of this spinal generator elicits rhythmic motor patterns of the striated musculature that surrounds the genital tract that contributes to the expulsion of seminal secretions. In the present study, we elicited ejaculation in spinal cord-transected male rats by mechanically stimulating the urethra and registered rhythmic motor patterns in the cremasteric, iliopsoas and pubococcygeus muscles. The rhythmic motor activity recorded in these muscles was compared with that elicited in the bulbospongiosus muscles; the results revealed similarities in the motor parameters among all the muscles. Data of this study, showing the occurrence of rhythmic motor behaviour in the cremasteric, iliopsoas and pubococcygeus muscles during ejaculation, suggest that these muscles might be under the control of the spinal generator for ejaculation.
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References
Newman H, Reiss H, Northurp JD . Physical basis of emission, ejaculation, and orgasm in the male. Urology 1982; 19: 341–350.
Mitsuya H, Asai J, Suyama K, Ushida T, Hosoe K . Application of x-ray cinematography in urology: I. Mechanism of ejaculation. J Urol 1976; 83: 86–92.
Watson JW . Mechanism of erection and ejaculation in bull and ram. Nature 1964; 404: 95–96.
Carro-Juárez M, Rodríguez-Manzo G . The spinal generator for ejaculation. Brain Res Rev 2008; 58: 106–120.
Carro-Juárez M, Rodríguez-Manzo G . Sensory and motor aspects of the coital reflex in the spinal male rat. Behav Brain Res 2000; 108: 97–103.
Truitt WA, Coolen LM . Identification of a potential ejaculation generator in the spinal cord. Science 2002; 297: 1566–1569.
Carro-Juárez M, Cruz SL, Rodríguez-Manzo G . Evidence for the involvement of a spinal pattern generator in the control of the genital motor pattern of ejaculation. Brain Res 2003; 975: 222–228.
Borgdorff AJ, Bernabé J, Denys P, Alexandre L, Giuliano F . Ejaculation elicited by microstimulation of lumbar spinothalamic neurons. Eur Urol 2008; 54: 449–456.
Clement P, Peeters M, Bernabe J, Laurin M, Alexandre L, Giuliano F . Role of the neurokinin-1 receptors in ejaculation in anesthetized rats. J Sex Med 2009; 6: 26–34.
Kozyrev N, Lehman MN, Coolen LM . Activation of gastrin-releasing peptide receptors in the lumbosacral spinal cord is required for ejaculation in male rats. J Sex Med 2012; 9: 1303–1318.
McKenna KE, Nadelhaft I . The pudendo-pudendal reflex in male and female rats. J Auton Nerv Syst 1989; 27: 67–77.
Vodusek BD, Janko M . The bulbocavernosus reflex. Brain 1990; 113: 813–820.
Shafik A, Shafik AA, Shafik I, El-Sibai O . Urethral sphincters response to cavernosus muscles stimulation with identification of cavernoso-urethral reflex. Arch Androl 2005; 51: 335–343.
Shafik A, El-Sibai O, Shafik A, Shafik I . Electromyographic study of the anterolateral abdominal wall muscles during ejaculation. J Sex Med 2007; 4: 1022–1027.
Shafik A, El-Sibai O . Mechanism of ejection during ejaculation: identification of a urethrocavernosus reflex. Arch Androl 2000; 44: 77–83.
Hrabovszky Z, Di Pilla N, Yap T, Farmer PJ, Hutson JM, Carlin JB . Role of the gubernacular bulb in cremaster muscle development of the rat. Anat Rec 2002; 267: 159–165.
Manzo J, Nicolas L, Hernández ME, Cruz MR, Carrillo P, Pacheco P . Spinal organization and steroid sensitivity of motoneurons Innervating the pubococcygeus muscle in the male rat. J Comp Neurol 1999; 409: 58–368.
Hernández-González M, Oropeza MV, Guevara MA, Cervantes M, Moralí G . Effects of intrathecal administration of adrenergic agonists on the frequency of copulatory pelvic thrusting of the male rat. Arch Med Res 1994; 25: 419–425.
Tanahashi M, Karicheti V, Thor KV, Marson L . Characterization of bulbospongiosus muscle reflexes activated by urethral distension in male rats. Am J Physiol Regul Integr Comp Physiol 2012; 303: R737–R747.
Hebel R, Stromberg MW . Anatomy of the Laboratory Rat. Williams and Williams: Baltimore, MD, USA, 1976.
Gregor M, Mejsnar J, Janovská A, Zurmanová J, Benada O, Mejsnarová B . Creatine kinase reaction in skinned rat psoas muscle fibers and their myofibrils. Physiol Res 1999; 48: 27–35.
Staudt MD, Truitt WA, McKenna KE, de Oliveira CV, Lehman MN, Coolen LM . A pivotal role of lumbar spinothalamic cells in the regulation of ejaculation via intraspinal connections. J Sex Med 2012; 9: 2256–2265.
Bacq ZM . Impotence of the male rodent after sympathetic denervation of the genital organs. Am J Physiol 1931; 96: 321–330.
Hart BL . Sexual reflexes and mating behaviour in the male rat. J Comp Physiol Psych 1968; 65: 453–460.
Delcomyn F . Neural basis of rhythmic behavior in animals. Science 1980; 210: 492–498.
Grillner S . Neurobiological bases of the rhythmic motor acts in vertebrates. Science 1985; 228: 143–149.
Kiehn O . Locomotor circuits in the mammalian spinal cord. Annu Rev Neurosci 2006; 29: 279–306.
Borgdorff AJ, Rössler AS, Clément P, Bernabé J, Alexandre L, Giuliano F . Differences in the spinal command of ejaculation in rapid ejaculating rats. J Sex Med 2009; 6: 2197–2205.
Courtois F, Carrier S, Charvier K, Guertin PA, Journel NM . The control of male sexual responses. Curr Pharm Des 2013; 19: 4341–4356.
Sakamoto H, Matsuda K, Zuloaga DG, Hongu H, Wada E, Wada K et al. Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions. Nat Neurosci 2008; 11: 634–636.
Zempoalteca R, Martínez-Gómez M, Hudson R, Cruz Y, Lucio RA . An anatomical and electrophysiological study of the genitofemoral nerve and some of its targets in the male rat. J Anat 2002; 201: 493–505.
McKenna KE, Nadelhaft I . The organization of the pudendal nerve in the male and female rat. J Comp Neurol 1986; 248: 532–549.
Ertekin C, Uysal H, Bademkiran F, Altay B . Sacrolumbar intersegmental reflex circuit in men and its relation to the ejaculatory process. Clin Neurophysiol 2007; 118: 2368–2374.
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Carro-Juárez, M., Rodríguez-Manzo, G., de Lourdes Rodríguez Peña, M. et al. Rhythmic motor patterns accompanying ejaculation in spinal cord-transected male rats. Int J Impot Res 26, 191–195 (2014). https://doi.org/10.1038/ijir.2014.4
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DOI: https://doi.org/10.1038/ijir.2014.4
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