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Rhythmic motor patterns accompanying ejaculation in spinal cord-transected male rats

International Journal of Impotence Research volume 26, pages 191–195 (2014)Cite this article

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Abstract

A spinal pattern generator controls the ejaculatory response. Activation of this spinal generator elicits rhythmic motor patterns of the striated musculature that surrounds the genital tract that contributes to the expulsion of seminal secretions. In the present study, we elicited ejaculation in spinal cord-transected male rats by mechanically stimulating the urethra and registered rhythmic motor patterns in the cremasteric, iliopsoas and pubococcygeus muscles. The rhythmic motor activity recorded in these muscles was compared with that elicited in the bulbospongiosus muscles; the results revealed similarities in the motor parameters among all the muscles. Data of this study, showing the occurrence of rhythmic motor behaviour in the cremasteric, iliopsoas and pubococcygeus muscles during ejaculation, suggest that these muscles might be under the control of the spinal generator for ejaculation.

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References

  1. Newman H, Reiss H, Northurp JD . Physical basis of emission, ejaculation, and orgasm in the male. Urology 1982; 19: 341–350.

    Article  CAS  Google Scholar 

  2. Mitsuya H, Asai J, Suyama K, Ushida T, Hosoe K . Application of x-ray cinematography in urology: I. Mechanism of ejaculation. J Urol 1976; 83: 86–92.

    Article  Google Scholar 

  3. Watson JW . Mechanism of erection and ejaculation in bull and ram. Nature 1964; 404: 95–96.

    Article  Google Scholar 

  4. Carro-Juárez M, Rodríguez-Manzo G . The spinal generator for ejaculation. Brain Res Rev 2008; 58: 106–120.

    Article  Google Scholar 

  5. Carro-Juárez M, Rodríguez-Manzo G . Sensory and motor aspects of the coital reflex in the spinal male rat. Behav Brain Res 2000; 108: 97–103.

    Article  Google Scholar 

  6. Truitt WA, Coolen LM . Identification of a potential ejaculation generator in the spinal cord. Science 2002; 297: 1566–1569.

    Article  CAS  Google Scholar 

  7. Carro-Juárez M, Cruz SL, Rodríguez-Manzo G . Evidence for the involvement of a spinal pattern generator in the control of the genital motor pattern of ejaculation. Brain Res 2003; 975: 222–228.

    Article  Google Scholar 

  8. Borgdorff AJ, Bernabé J, Denys P, Alexandre L, Giuliano F . Ejaculation elicited by microstimulation of lumbar spinothalamic neurons. Eur Urol 2008; 54: 449–456.

    Article  Google Scholar 

  9. Clement P, Peeters M, Bernabe J, Laurin M, Alexandre L, Giuliano F . Role of the neurokinin-1 receptors in ejaculation in anesthetized rats. J Sex Med 2009; 6: 26–34.

    Google Scholar 

  10. Kozyrev N, Lehman MN, Coolen LM . Activation of gastrin-releasing peptide receptors in the lumbosacral spinal cord is required for ejaculation in male rats. J Sex Med 2012; 9: 1303–1318.

    Article  CAS  Google Scholar 

  11. McKenna KE, Nadelhaft I . The pudendo-pudendal reflex in male and female rats. J Auton Nerv Syst 1989; 27: 67–77.

    Article  CAS  Google Scholar 

  12. Vodusek BD, Janko M . The bulbocavernosus reflex. Brain 1990; 113: 813–820.

    Article  Google Scholar 

  13. Shafik A, Shafik AA, Shafik I, El-Sibai O . Urethral sphincters response to cavernosus muscles stimulation with identification of cavernoso-urethral reflex. Arch Androl 2005; 51: 335–343.

    Article  CAS  Google Scholar 

  14. Shafik A, El-Sibai O, Shafik A, Shafik I . Electromyographic study of the anterolateral abdominal wall muscles during ejaculation. J Sex Med 2007; 4: 1022–1027.

    Article  Google Scholar 

  15. Shafik A, El-Sibai O . Mechanism of ejection during ejaculation: identification of a urethrocavernosus reflex. Arch Androl 2000; 44: 77–83.

    Article  CAS  Google Scholar 

  16. Hrabovszky Z, Di Pilla N, Yap T, Farmer PJ, Hutson JM, Carlin JB . Role of the gubernacular bulb in cremaster muscle development of the rat. Anat Rec 2002; 267: 159–165.

    Article  Google Scholar 

  17. Manzo J, Nicolas L, Hernández ME, Cruz MR, Carrillo P, Pacheco P . Spinal organization and steroid sensitivity of motoneurons Innervating the pubococcygeus muscle in the male rat. J Comp Neurol 1999; 409: 58–368.

    Article  Google Scholar 

  18. Hernández-González M, Oropeza MV, Guevara MA, Cervantes M, Moralí G . Effects of intrathecal administration of adrenergic agonists on the frequency of copulatory pelvic thrusting of the male rat. Arch Med Res 1994; 25: 419–425.

    PubMed  Google Scholar 

  19. Tanahashi M, Karicheti V, Thor KV, Marson L . Characterization of bulbospongiosus muscle reflexes activated by urethral distension in male rats. Am J Physiol Regul Integr Comp Physiol 2012; 303: R737–R747.

    Article  CAS  Google Scholar 

  20. Hebel R, Stromberg MW . Anatomy of the Laboratory Rat. Williams and Williams: Baltimore, MD, USA, 1976.

    Google Scholar 

  21. Gregor M, Mejsnar J, Janovská A, Zurmanová J, Benada O, Mejsnarová B . Creatine kinase reaction in skinned rat psoas muscle fibers and their myofibrils. Physiol Res 1999; 48: 27–35.

    CAS  PubMed  Google Scholar 

  22. Staudt MD, Truitt WA, McKenna KE, de Oliveira CV, Lehman MN, Coolen LM . A pivotal role of lumbar spinothalamic cells in the regulation of ejaculation via intraspinal connections. J Sex Med 2012; 9: 2256–2265.

    Article  CAS  Google Scholar 

  23. Bacq ZM . Impotence of the male rodent after sympathetic denervation of the genital organs. Am J Physiol 1931; 96: 321–330.

    Article  Google Scholar 

  24. Hart BL . Sexual reflexes and mating behaviour in the male rat. J Comp Physiol Psych 1968; 65: 453–460.

    Article  CAS  Google Scholar 

  25. Delcomyn F . Neural basis of rhythmic behavior in animals. Science 1980; 210: 492–498.

    Article  CAS  Google Scholar 

  26. Grillner S . Neurobiological bases of the rhythmic motor acts in vertebrates. Science 1985; 228: 143–149.

    Article  CAS  Google Scholar 

  27. Kiehn O . Locomotor circuits in the mammalian spinal cord. Annu Rev Neurosci 2006; 29: 279–306.

    Article  CAS  Google Scholar 

  28. Borgdorff AJ, Rössler AS, Clément P, Bernabé J, Alexandre L, Giuliano F . Differences in the spinal command of ejaculation in rapid ejaculating rats. J Sex Med 2009; 6: 2197–2205.

    Article  Google Scholar 

  29. Courtois F, Carrier S, Charvier K, Guertin PA, Journel NM . The control of male sexual responses. Curr Pharm Des 2013; 19: 4341–4356.

    Article  CAS  Google Scholar 

  30. Sakamoto H, Matsuda K, Zuloaga DG, Hongu H, Wada E, Wada K et al. Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions. Nat Neurosci 2008; 11: 634–636.

    Article  CAS  Google Scholar 

  31. Zempoalteca R, Martínez-Gómez M, Hudson R, Cruz Y, Lucio RA . An anatomical and electrophysiological study of the genitofemoral nerve and some of its targets in the male rat. J Anat 2002; 201: 493–505.

    Article  Google Scholar 

  32. McKenna KE, Nadelhaft I . The organization of the pudendal nerve in the male and female rat. J Comp Neurol 1986; 248: 532–549.

    Article  CAS  Google Scholar 

  33. Ertekin C, Uysal H, Bademkiran F, Altay B . Sacrolumbar intersegmental reflex circuit in men and its relation to the ejaculatory process. Clin Neurophysiol 2007; 118: 2368–2374.

    Article  Google Scholar 

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Authors and Affiliations

  1. Laboratorio de Comportamiento Reproductivo, Escuela de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Tlaxcala, Tlaxcala, México

    M Carro-Juárez, M de Lourdes Rodríguez Peña & M Á Franco

  2. Departamento de Farmacobiología, Cinvestav-SedeSur, Calzada de los Tenorios 235, Col Granjas Coapa, Delegación Tlalpan, México D.F., Mexico City, México

    G Rodríguez-Manzo

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  1. M Carro-Juárez
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  4. M Á Franco
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Correspondence to M Carro-Juárez.

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Carro-Juárez, M., Rodríguez-Manzo, G., de Lourdes Rodríguez Peña, M. et al. Rhythmic motor patterns accompanying ejaculation in spinal cord-transected male rats. Int J Impot Res 26, 191–195 (2014). https://doi.org/10.1038/ijir.2014.4

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