Abstract
Mutations in SOX9 are associated with male-to-female sex reversal in humans1,2. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Wagner, T. et al. Cell 79, 1111–1120 (1994).
Foster, J.W. et al. Nature 372, 525–530 (1994).
Swain, A. & Lovell Badge, R. Genes Dev. 13, 755–767 (1999).
Morais da Silva, S. et al. Nature Genet. 14, 62–68 (1996).
Kent, J., Wheatley, S.C., Andrews, J.E., Sinclair, A.H. & Koopman, P. Development 122, 2813–2822 (1996).
Bergstrom, D.E., Young, M., Albrecht, K.H. & Eicher, E.M. Genesis. 28, 111–124 (2000).
De Santa Barbara, P. et al. Mol. Cell Biol. 18, 6653–6665 (1998).
Arango, N.A., Lovell-Badge, R. & Behringer, R.R. Cell 99, 409–419 (1999).
Moore, A.W. et al. Mech. Dev. 79, 169–184 (1998).
Scholz, H. et al. J. Biol. Chem. 272, 32836–32846 (1997).
Schedl, A., Montoliu, L., Kelsey, G. & Schutz, G. Nature 362, 258–261 (1993).
Hunt, P.A. et al. Mol. Reprod. Dev. 49, 101–111 (1998).
Bishop, C.E. et al. Nature Genet. 26, 490–494 (2000).
Huang, B., Wang, S., Ning, Y., Lamb, A.N. & Bartley, J. Am. J. Med. Genet. 87, 349–353 (1999).
Pask, A. & Graves, J.A. Cell Mol. Life Sci. 55, 864–875 (1999).
Acknowledgements
We thank U. Ziegler, S. Schmidt, S. Lützkendorf and D. Landrock for excellent technical assistance. This work was supported by the Volkswagen Stiftung and EC-grant QLRT00741.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Vidal, V., Chaboissier, MC., de Rooij, D. et al. Sox9 induces testis development in XX transgenic mice. Nat Genet 28, 216–217 (2001). https://doi.org/10.1038/90046
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/90046
This article is cited by
-
An exploratory study for tuft cells in the breast and their relevance in triple-negative breast cancer: the possible relationship of SOX9
BMC Cancer (2023)
-
PRC1 suppresses a female gene regulatory network to ensure testicular differentiation
Cell Death & Disease (2023)
-
Molecular cloning and expression patterns of a sex-biased transcriptional factor Foxl2 in the giant freshwater prawn (Macrobrachium rosenbergii)
Molecular Biology Reports (2023)
-
Loss of NEDD4 causes complete XY gonadal sex reversal in mice
Cell Death & Disease (2022)
-
Shedding new light on early sex determination in zebrafish
Archives of Toxicology (2020)