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Cancer

When antioxidants are bad

Reactive oxygen species (ROS) get a bad press, as evidenced by the notable trend in the use of dietary and cosmetic antioxidants. New work suggests, however, that ROS might have a role in mitigating certain cancers. See Letter p.106

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Figure 1: The right balance of reactive oxygen species (ROS).

References

  1. Vafa, O. et al. Mol. Cell 9, 1031–1044 (2002).

    Article  CAS  Google Scholar 

  2. Irani, K. et al. Science 275, 1649–1652 (1997).

    Article  CAS  Google Scholar 

  3. DeNicola, G. M. et al. Nature 475, 106–109 (2011).

    Article  CAS  Google Scholar 

  4. Gao, P. et al. Cancer Cell 12, 230–238 (2007).

    Article  CAS  Google Scholar 

  5. Gao, P. et al. Nature 458, 762–765 (2009).

    Article  ADS  CAS  Google Scholar 

  6. Kensler, T. W., Wakabayashi, N. & Biswal, S. Annu. Rev. Pharmacol. Toxicol. 47, 89–116 (2007).

    Article  CAS  Google Scholar 

  7. Hayes, J. D. & McMahon, M. Trends Biochem Sci. 34, 176–188 (2009).

    Article  CAS  Google Scholar 

  8. Sablina, A. A. et al. Nature Med. 11, 1306–1313 (2005).

    Article  CAS  Google Scholar 

  9. Yang, S. et al. Genes Dev. 25, 717–729 (2011).

    Article  CAS  Google Scholar 

  10. Trachootham, D., Alexandre, J. & Huang, P. Nature Rev. Drug Discov. 8, 579–591 (2009).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Rushika M. Perera or Nabeel Bardeesy.

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Perera, R., Bardeesy, N. When antioxidants are bad. Nature 475, 43–44 (2011). https://doi.org/10.1038/475043a

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