Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stem cells

Interactive niches

The microenvironment, or niche, in which stem cells reside controls their renewal and maturation. The niche that regulates blood-forming stem cells in adult animals has eluded researchers — until now.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Birth control for stem cells.

References

  1. Kiger, A. A., Jones, D. L., Schulz, C., Rogers, M. B. & Fuller, M. T. Science 294, 2542–2545 (2001).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Spradling, A., Drummond-Barbosa, D. & Kai, T. Nature 414, 98–104 (2001).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Kopan, R. et al. Dev. Biol. 242, 44–57 (2002).

    Article  CAS  PubMed  Google Scholar 

  4. Marshman, E., Booth, C. & Potten, C. S. BioEssays 24, 91–98 (2002).

    Article  PubMed  Google Scholar 

  5. Nishimura, E. K. et al. Nature 416, 854–860 (2002).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Alonso, L. & Fuchs, E. Proc. Natl Acad. Sci. USA 100, 11830–11835 (2003).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  7. Zhang, J. et al. Nature 425, 836–841 (2003).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Calvi, L. M. et al. Nature 425, 841–846 (2003).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Lord, B. I. Int. J. Cell Cloning 8, 317–331 (1990).

    Article  CAS  PubMed  Google Scholar 

  10. Nilsson, S. K., Johnston, H. M. & Coverdale, J. A. Blood 97, 2293–2299 (2001).

    Article  CAS  PubMed  Google Scholar 

  11. Dexter, T. M., Allen, T. D. & Lajtha, L. G. J. Cell. Physiol. 91, 335–344 (1977).

    Article  CAS  PubMed  Google Scholar 

  12. Moore, K. A. Blood 89, 4337–4347 (1997).

    CAS  PubMed  Google Scholar 

  13. Taichman, R. S. & Emerson, S. G. Stem Cells 16, 7–15 (1998).

    Article  CAS  PubMed  Google Scholar 

  14. Reya, T. et al. Nature 423, 409–414 (2003).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Chi, J.-T. et al. Proc. Natl Acad. Sci. USA 100, 10623–10628 (2003).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ihor R. Lemischka.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lemischka, I., Moore, K. Interactive niches. Nature 425, 778–779 (2003). https://doi.org/10.1038/425778a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/425778a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing