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Volume 33 Issue 2, February 2023

A study identified a novel APOE4-specific receptor LilrB3. A butterfly-like Cryo-EM structure of the complex reveals the details of how the immune “checkpoint” receptor LilrB3 recognizes APOE4. Upon binding, it will induce microglia cell into an Alzheimer Disease-associated status. See page 116–130 by Jiayao Zhou et al. for details.

Research Highlight

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Review Article

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Letter to the Editor

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