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The image tells a fable story, ‘dirty partner’. A wolf and a jackal often do evil things in collusion with each other. In KRAS-driven cancers, KRAS mutations are like wolves and RASON behaves like a jackal. KRAS mutations initiate tumour formation and promote tumour progression which are enhanced by RASON, a novel protein encoded by long non-coding RNA, LINC00673, and overexpressed in tumour to regulate RAS activity. Cover art is contributed by Chao Yan. See page 30–45 by Rongjie Cheng et al. for details.