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Volume 27 Issue 2, February 2017

Research Highlight

  • One of the key questions regarding macroautophagy/autophagy is the mechanism through which the transmembrane protein ATG9 functions in delivering membrane to the expanding phagophore, the sequestering compartment that matures into an autophagosome. In a recent study, Zhou et al. identified a novel mechanism that regulates ATG9 trafficking from the plasma membrane and trans-Golgi network, which involves two conserved sorting signals required for ATG9 interaction with the AP1/2 adaptor complex and phosphorylation of ATG9 at Tyr8 by SRC kinase and at Ser14 by ULK1 for proper function during basal and starvation-induced autophagy.

    • Yuchen Feng
    • Daniel J Klionsky
    Research Highlight


  • Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated genes (cas) are essential components of an adaptive immune system that protects bacteria and archaea from viral infection. Now a recent paper published in Cell Research suggests that the Type I-F immune system in Pseudomonas aeruginosa may also be involved in post-transcriptional regulation of virulence.

    • Blake Wiedenheft
    • Joseph Bondy-Denomy
    Research Highlight
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Original Article

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Letter to the Editor

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