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Volume 26 Issue 6, June 2016

Research Highlight

  • Mechanical deformability is known to increase during cancer progression. Now Ma et al. identify a therapeutic strategy that targets deformable cells by microparticle-based drug delivery.

    • Jens Hamann
    • Michael Overholtzer
    Research Highlight


  • For decades, MYC has been known for its role in regulating cancer cell proliferation and survival. In a recent paper published in Science, Casey et al. have uncovered a new function for MYC in promoting immune evasion by directly regulating expression of programmed death-ligand 1 (PD-L1) and CD47 on cancer cells.

    • Stefani Spranger
    • Thomas F Gajewski
    • Justin Kline
    Research Highlight
  • Rupture of the nuclear envelope (NE) during interphase is thought to be an infrequent event in healthy cells. Two papers recently published in Science describe the transient disruption of the NE continuity in cells migrating through confined spaces, and uncover an essential role for the Endosomal Sorting Complex Required for Transport (ESCRT) machinery in the resealing of these nuclear discontinuities.

    • Leandro N Ventimiglia
    • Juan Martin-Serrano
    Research Highlight
  • Whether mixed lineage kinase domain-like (MLKL) mediates necroptosis by forming ion channel, none-selective pore, or simply by disrupting plasma membrane is unclear. In a paper published in recent issue of Cell Research, Xia et al. showed that MLKL functions as a novel class of cation channel.

    • Yingying Zhang
    • Jiahuai Han
    Research Highlight
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Original Article

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Letter to the Editor

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