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Volume 26 Issue 12, December 2016

Research Highlight

  • Cells and organisms adapt to mitochondrial dysfunction by activating the mitochondrial unfolded protein response (UPRmt), which is regulated by mitochondrial-to-nuclear communication; and UPRmt activation can also be transmitted between different cell types suggesting a role in tissue coordination. Shao and colleagues now identify a neuronal circuit and a secreted neuropeptide required for cell non-autonomous UPRmt regulation.

    • Pan Deng
    • Cole M Haynes
    Research Highlight


  • A recent paper published in Nature reports that the immunosuppressive activity of tumor-associated macrophages is regulated via PI3Kγ signaling. Small-molecule inhibitors targeting PI3Kγ stimulate T cell activity against tumor alone and add additional effects for clinically proven PD1 immunotherapy.

    • Wei Zheng
    • Jeffrey W Pollard
    Research Highlight
  • Recent evidence indicates that codon optimality is a broad determinant of mRNA stability. A study by Radhakrishnan et al. in Cell raises the possibility that the conserved DEAD-box protein Dhh1 underlies the phenomenon.

    • Yuriko Harigaya
    • Roy Parker
    Research Highlight
  • A near-atomic resolution structure of a mammalian voltage-gated calcium channel (Cav) has been determined. This first fully-assembled Cav structure illuminates mechanisms of Cav properties and functions and ushers in a new era in Cav research and beyond.

    • Jian Yang
    Research Highlight
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Original Article

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Letter to the Editor

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