FOCUS
DNA DAMAGE RESPONSES AND GENOME MAINTENANCE
- Focus issue:
- January 2008 Volume 18, No 1
This focus presents a collection of review and research articles that outline our current understanding of the genome maintenance systems involved in DNA damage detection, signaling, response and repair.
Letters
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins
Ivan Ahel, Dragana Ahel, Takahiro Matsusaka, Allison J. Clark, Jonathon Pines, Simon J. Boulton and Stephen C. West
Nature 451; 81-85; doi:10.1038/nature06420
First paragraph | Full Text | PDF (264K) | Supplementary Information
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Eros Lazzerini Denchi and Titia de Lange
Nature 448, 1068-1071; doi:10.1038/nature06065
First paragraph | Full Text | PDF (752K) | Supplementary Information
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Derrick J. Rossi, David Bryder, Jun Seita, Andre Nussenzweig, Jan Hoeijmakers and Irving L. Weissman
Nature 447, 725-729; doi:10.1038/nature05862
First paragraph | Full Text | PDF (577K) | Supplementary Information
p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
Hoseok Song, Monica Hollstein and Yang Xu
Nature Cell Biology 9, 573-580; doi:10.1038/ncb1571
First paragraph | Full Text | PDF (2,638K) | Supplementary Information
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
Elen Griffith, Sarah Walker, Carol-Anne Martin, Paola Vagnarelli, Tom Stiff, Bertrand Vernay, Nouriya Al Sanna, Anand Saggar, Ben Hamel, William C Earnshaw, Penny A Jeggo, Andrew P Jackson and Mark O'Driscoll
Nature Genetics 40, 232-236; doi:10.1038/ng.2007.80
First paragraph | Full Text | PDF (665K) | Supplementary Information
Articles
Preferential loss of mismatch repair function in refractory and relapsed acute myeloid leukemia: potential contribution to AML progression FREE
Guogen Mao, Fenghua Yuan, Kimberly Absher, C Darrell Jennings, Dianna S Howard, Craig T Jordan and Liya Gu
Cell Research 18, 281-289; doi: 10.1038/cr.2008.14
Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair FREE
Longhou Fang, YiGuo Wang, Dan Du, Guang Yang, Tim Tak Kwok, Siu Kai Kong, Benjamin Chen, David J Chen and Zhengjun Chen
Cell Research 17, 100-116; doi: 10.1038/sj.cr.7310145
Abstract | Full Text | PDF (1,054K) | Supplementary Information
Human CtIP promotes DNA end resection
Alessandro A. Sartori, Claudia Lukas, Julia Coates, Martin Mistrik, Shuang Fu, Jiri Bartek, Richard Baer, Jiri Lukas and Stephen P. Jackson
Nature 450, 509-514; doi:10.1038/nature06337
Abstract | Full Text | PDF (1,734K) | Supplementary Information
Recognition of DNA damage by the Rad4 nucleotide excision repair protein
Jung-Hyun Min and Nikola P. Pavletich
Nature 449, 570-575; doi:10.1038/nature06155
Abstract | Full Text | PDF (1,054K) | Supplementary Information
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
Irina V. Kovtun, Yuan Liu, Magnar Bjoras, Arne Klungland, Samuel H. Wilson and Cynthia T. McMurray
Nature 447, 447-452; doi:10.1038/nature05778
Abstract | Full Text | PDF (602K) | Supplementary Information
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