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In a recent paper published in Cell Research, Yan Bao and colleagues characterize a new population of IFNγ-producing innate-like B cells that promotes innate immune responses and contributes to early pathogen control following intracellular bacterial infection.
A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conversion within the native physiological niche; this technology may provide a time- and cost-effective alternative for applications in regenerative medicine and may also minimize the concerns associated with in vitro culture and cell transplantation.