Announcements

  • Magnifying lens over bar graph in black and white.

    Communications Medicine is a recently launched fully open access journal already indexed in ESCI, PubMed Central, DOAJ, and Google Scholar. It takes 7 days from submission to the first editorial decision (median).

  • Blood cells within a vessel with atherosclerosis

    This cross-journal Collection welcomes submissions on molecular approaches for risk stratification, or focused on established or new targets, to reduce hyperlipidaemia, with a view to clinical translation and prevention of ASCVD.

    Open for submissions
  • A number of vaccine vials

    This cross-journal Collection welcomes submissions that propose technological advancements in vaccine/antigen design, target combinations, delivery systems for any pathogen groups, as well as adjunctive therapies.

    Open for submissions

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  • Wang, Yang et al. propose KnowDDI, a graph neural network that leverages biomedical knowledge graphs for drug-drug interaction predictions. The model yields improved performance and interpretability over existing methods, especially in scenarios with sparse knowledge graphs, marking a significant advancement in biomedicine and healthcare.

    • Yaqing Wang
    • Zaifei Yang
    • Quanming Yao
    ArticleOpen Access
  • Ptacin et al. utilize a semi-synthetic microbial platform with an expanded genetic code to discover a PEGylated IL-2 compound that stimulates Tregs, with minimal effects on effector populations. Studies in mice and primates demonstrate Treg stimulation and support development of this compound for the potential treatment of autoimmune diseases.

    • Jerod L. Ptacin
    • Lina Ma
    • Marcos E. Milla
    ArticleOpen Access
  • Robitaille et al. report findings from a phase IIb randomized placebo-controlled trial evaluating the effect of a long-chain omega-3 fatty acid MAG-EPA dietary supplement on prostate cancer proliferation. The dietary supplement had no effect on the primary outcome of prostate cancer proliferation according to Ki-67 expression.

    • Karine Robitaille
    • Marie-Hélène Guertin
    • Vincent Fradet
    ArticleOpen Access
  • Le Buanec, Schiavon, Merandet et al. study the underlying immune responses for the elevation of IFNα that occurs during an antiretroviral treatment interruption in HIV patients. IFNα mediated induction of CCR5 is shown to promote pathogenic phenotype, while elite controllers avoid this by an unknown genetic factor or a low inoculum infection.

    • Hélène Le Buanec
    • Valérie Schiavon
    • Robert C. Gallo
    ArticleOpen Access
  • Le Buanec et al. compared distribution and frequency of cell markers associated with immune dysfunction between HIV elite controllers (EC) and untreated non-EC. They demonstrate that untreated HIV-infected individuals exhibit structurally and functionally impaired immune subsets, as a consequence of excessive levels of serum IFNα.

    • Hélène Le Buanec
    • Valérie Schiavon
    • Daniel Zagury
    ArticleOpen Access
  • Wu, Zeng et al. assess the feasibility and efficacy of AAV9:PKP2 gene therapy in the Pkp2-cKO mouse model of arrhythmogenic right ventricular cardiomyopathy. They show that it ameliorates ventricular arrhythmias, reverses adverse right ventricular remodeling, improves heart function, and reduces mortality in this mouse model.

    • Iris Wu
    • Aliya Zeng
    • Zhihong Jane Yang
    ArticleOpen Access
  • Thirunavukkarasu et al. discuss how standard lifestyle interventions prove ineffective in preventing type 2 diabetes in individuals with isolated impaired fasting glucose, a highly prevalent prediabetes phenotype globally. They propose low-calorie diets as a promising strategy for diabetes prevention in this high-risk population.

    • Sathish Thirunavukkarasu
    • Roy Taylor
    • Jonathan E. Shaw
    CommentOpen Access
  • Zhang et al. discuss how artificial intelligence (AI) can be used to optimize clinical trial design and potentially boost the success rate of clinical trials. AI has unparalleled potential to leverage real-world data and unlock valuable insights for innovative trial design.

    • Bin Zhang
    • Lu Zhang
    • Shuixing Zhang
    CommentOpen Access
  • Ivancovsky-Wajcman et al. outline the need for a holistic preventive hepatology approach, involving social nutrition and social prescribing, to address the public health threat of metabolic dysfunction-associated steatotic liver disease (MASLD). They argue that this will facilitate individuals’ engagement in behavioural modifications to treat MASLD.

    • Dana Ivancovsky-Wajcman
    • Paul N. Brennan
    • Jeffrey V. Lazarus
    CommentOpen Access
  • Macharia et al. discuss a Communications Medicine article on global healthcare accessibility and the impact of the COVID-19 pandemic. They outline strengths in the comprehensive approach taken to studying revealed versus potential spatial accessibility, plus some limitations and wider context with which the results can be interpreted.

    • Peter M. Macharia
    • Aduragbemi Banke-Thomas
    • Lenka Beňová
    CommentOpen Access
  • Pallett et al. discuss the impact of human conflict on development of antimicrobial resistance. They overview approaches to limit the spread of antimicrobial resistance, using the ongoing conflict in Ukraine as an example of the challenges and opportunities.

    • Scott J. C. Pallett
    • Sara E. Boyd
    • Emma J. Hutley
    CommentOpen Access
  • Dr. Kamilla Kamaruddin is a general practitioner in Transgender Health Care and Clinical Lead at the East of England Gender Service, Cambridge, UK. She is also a board member for sexual health and wellbeing organisation Spectra-London, trustee at LGBTQ+ cancer charity Live Through This, and health advisor for trans community organisation TransActual UK. In this Q&A, we ask Dr. Kamaruddin a series of questions on the difficulties transgender people face in accessing quality healthcare, with a particular focus on the UK.

    Q&AOpen Access
Endoscopy

Endoscopy

This cross journal collection on endoscopy brings together technological advances to improve capability, with clinical research exploring procedures and applications.
Collection
Open for submissions

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