Park et al. assess the therapeutic efficacy of mitochondrial transplantation with or without O-GlcNAc modification of isolated mitochondria. O-GlcNAcylation can prevent glycation while improving both the functional properties of mitochondria and the neuroprotective efficacy of transplantation in a mouse model of focal cerebral ischemia.

Caroppo, Calabrese et al. monitor the mental health of 100 asylum-seekers during a 14-day COVID19 related quarantine in reception facilities in Rome, Italy. Asylum-seekers are more likely to experience post-traumatic stress disorder than the general population, but a supportive environment during quarantine enhances their psychological well-being.

Macharia et al. discuss a Communications Medicine article on global healthcare accessibility and the impact of the COVID-19 pandemic. They outline strengths in the comprehensive approach taken to studying revealed versus potential spatial accessibility, plus some limitations and wider context with which the results can be interpreted.

Gligorić, Kamath, Weiss et al. evaluate revealed versus potential travel times to healthcare facilities in over 100 countries using anonymized smartphone location history data. The authors study the impact of the COVID-19 pandemic on travel times and correlate travel times with key population health indicators.

Yoshioka, Taniguchi, Homma et al. study the effect of AAV-delivered Cas9 and specific guide RNAs to correct the PMP22 gene duplication that causes Charcot-Marie-Tooth disease type 1A. They measured the effect of Cas9 editing in iPSC cells on PMP22 expression and demonstrated how editing reduces cell death and myelination defects in edited iPSC-derived Schwann cells.

Avery et al. utilize data from the UK Biobank in a multivariable Mendelian randomization study to evaluate the effects of branched chain amino acids (BCAAs) on human disease. Their findings suggest observational studies of BCAA phenotypic effects are prone to substantial error, potentially misleading efforts to develop novel therapeutics.

Park et al. assess the therapeutic efficacy of mitochondrial transplantation with or without O-GlcNAc modification of isolated mitochondria. O-GlcNAcylation can prevent glycation while improving both the functional properties of mitochondria and the neuroprotective efficacy of transplantation in a mouse model of focal cerebral ischemia.

Cai et al. develop and evaluate mpox A29 surface envelop protein-based enzyme immunoassay to analyze seroprevalence and B cell responses after natural mpox viral infection or vaccination. The assay can readily detect mpox A29-specific B cells and antibody in the serum of mpox patients and MVA-BN vaccine recipients.

Caroppo, Calabrese et al. monitor the mental health of 100 asylum-seekers during a 14-day COVID19 related quarantine in reception facilities in Rome, Italy. Asylum-seekers are more likely to experience post-traumatic stress disorder than the general population, but a supportive environment during quarantine enhances their psychological well-being.

Bruneau et al. simulate high-fidelity fluid-structure interactions to model intracranial sounds. Spectrograms of the simulated vibrations are consistent with previously-reported microphone and Doppler ultrasound recordings.

Ivancovsky-Wajcman et al. outline the need for a holistic preventive hepatology approach, involving social nutrition and social prescribing, to address the public health threat of metabolic dysfunction-associated steatotic liver disease (MASLD). They argue that this will facilitate individuals’ engagement in behavioural modifications to treat MASLD.

Macharia et al. discuss a Communications Medicine article on global healthcare accessibility and the impact of the COVID-19 pandemic. They outline strengths in the comprehensive approach taken to studying revealed versus potential spatial accessibility, plus some limitations and wider context with which the results can be interpreted.

Pallet et al. discuss the impact of human conflict on development of antimicrobial resistance. They overview approaches to limit the spread of antimicrobial resistance, using the ongoing conflict in Ukraine as an example of the challenges and opportunities.

Dr. Kamilla Kamaruddin is a general practitioner in Transgender Health Care and Clinical Lead at the East of England Gender Service, Cambridge, UK. She is also a board member for sexual health and wellbeing organisation Spectra-London, trustee at LGBTQ+ cancer charity Live Through This, and health advisor for trans community organisation TransActual UK. In this Q&A, we ask Dr. Kamaruddin a series of questions on the difficulties transgender people face in accessing quality healthcare, with a particular focus on the UK.

Kooman outlines the findings of a Communications Medicine article on deep learning-based detection of chronic kidney disease using ECGs. The author interprets the study’s findings in light of its limitations and outlines key considerations in the clinical implementation of such an approach.

Today is Global Recycling Day. All medical practices and disciplines face sustainability issues and there is a huge focus in the UK on minimising the environmental effects of medicine. Here we speak to Dr Daniel Lake about ‘Project Greener Anaesthesia’, which aims to do just that for Anaesthetics.