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  • Thirunavukkarasu et al. discuss how standard lifestyle interventions prove ineffective in preventing type 2 diabetes in individuals with isolated impaired fasting glucose, a highly prevalent prediabetes phenotype globally. They propose low-calorie diets as a promising strategy for diabetes prevention in this high-risk population.

    • Sathish Thirunavukkarasu
    • Roy Taylor
    • Jonathan E. Shaw
    CommentOpen Access
  • Zhang et al. discuss how artificial intelligence (AI) can be used to optimize clinical trial design and potentially boost the success rate of clinical trials. AI has unparalleled potential to leverage real-world data and unlock valuable insights for innovative trial design.

    • Bin Zhang
    • Lu Zhang
    • Shuixing Zhang
    CommentOpen Access
  • Ivancovsky-Wajcman et al. outline the need for a holistic preventive hepatology approach, involving social nutrition and social prescribing, to address the public health threat of metabolic dysfunction-associated steatotic liver disease (MASLD). They argue that this will facilitate individuals’ engagement in behavioural modifications to treat MASLD.

    • Dana Ivancovsky-Wajcman
    • Paul N. Brennan
    • Jeffrey V. Lazarus
    CommentOpen Access
  • Macharia et al. discuss a Communications Medicine article on global healthcare accessibility and the impact of the COVID-19 pandemic. They outline strengths in the comprehensive approach taken to studying revealed versus potential spatial accessibility, plus some limitations and wider context with which the results can be interpreted.

    • Peter M. Macharia
    • Aduragbemi Banke-Thomas
    • Lenka Beňová
    CommentOpen Access
  • Pallett et al. discuss the impact of human conflict on development of antimicrobial resistance. They overview approaches to limit the spread of antimicrobial resistance, using the ongoing conflict in Ukraine as an example of the challenges and opportunities.

    • Scott J. C. Pallett
    • Sara E. Boyd
    • Emma J. Hutley
    CommentOpen Access
  • Kooman outlines the findings of a Communications Medicine article on deep learning-based detection of chronic kidney disease using ECGs. The author interprets the study’s findings in light of its limitations and outlines key considerations in the clinical implementation of such an approach.

    • Jeroen P. Kooman
    CommentOpen Access
  • Schattenberg et al. outline discussions from a recent workshop on NAFLD care and advocate for a multidisciplinary approach to managing this complex and multifactorial disease. The authors highlight gaps in current models of care and make recommendations on optimising a multistakeholder approach in steatotic liver diseases.

    • Jörn M. Schattenberg
    • Alina M. Allen
    • Jeffrey V. Lazarus
    CommentOpen Access
  • Dastidar et al. discuss how recent policy measures, and favourable technological and infrastructural landscapes are bolstering India’s ability to implement virtual care. These developments were accelerated by the need for an alternative model of care during the COVID-19 lockdowns and may provide a bridge to Universal Healthcare in India.

    • Biswanath Ghosh Dastidar
    • Shailesh Suri
    • Anant Jani
    CommentOpen Access
  • Sinaki et al. highlight ethnic disparities in the populations of 12 publicly-available pulse oximetry databases. The authors outline the potential consequences of such disparities on pulse oximetry device and algorithm development.

    • Fatemeh Y. Sinaki
    • Rabab Ward
    • Mohamed Elgendi
    CommentOpen Access
  • van Dijk et al. discuss the potential for antimicrobial resistance as a consequence of disinfectant use. The authors advocate for the prudent use of disinfectants in all sectors of society.

    • Harrie F. G. van Dijk
    • Henri A. Verbrugh
    • Andreas Voss
    CommentOpen Access
  • Bast et al. discuss the early detection of ovarian cancer in the context of the recent UKCTOCS screening trial. The authors suggest potential reasons why the trial failed to achieve a reduction in mortality and outline next steps in the development of biomarkers and imaging modalities to detect ovarian cancer.

    • Robert C. Bast
    • Chae Young Han
    • Karen H. Lu
    CommentOpen Access
  • Kurtovic et al. highlight some of the recent advances in the development and clinical evaluation of malaria vaccines. The authors outline key vaccine strategies and clinical trials, and discuss priorities for research into the development of an efficacious malaria vaccine.

    • Liriye Kurtovic
    • Linda Reiling
    • James G. Beeson
    CommentOpen Access
  • Vokinger et al. discuss potential sources of bias in machine learning systems used in medicine. The authors propose solutions to mitigate bias across the different stages of model development, from data collection and preparation to model evaluation and application.

    • Kerstin N. Vokinger
    • Stefan Feuerriegel
    • Aaron S. Kesselheim
    CommentOpen Access
  • Alwan discusses the lessons learnt over the past year regarding Long COVID, prolonged illness resulting from SARS-CoV-2 infection, and their implications for public health policy and disease management, drawing insight form her own lived experience, research, and advocacy work with Long COVID.

    • Nisreen A. Alwan
    CommentOpen Access
  • Kundu discusses how artificial intelligence will transform medical practice and doctors’ training. The author explores the changing role of the clinician in the doctor-patient relationship, drawing parallels with the role of the pilot in light of increased automation in aviation.

    • Shinjini Kundu
    CommentOpen Access
  • Kurtzhals et al. mark the centenary of the discovery of insulin by looking back at how this model protein has changed science and medicine. They discuss how lessons learned from insulin over the last one hundred years are shaping the present and future of protein-based therapies for chronic disease.

    • Peter Kurtzhals
    • Bernt Johan von Scholten
    • Stephen Charles Langford Gough
    CommentOpen Access