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  • People with psychiatric disorders often experience sleep problems. A recent post hoc cross-sectional study in PLoS Medicine used movement readings from participants’ wrists to assess their sleep and then investigated associations with several psychiatric disorders.

    • Katharine Barnes
    Research Highlight Open Access
  • Air pollution is a major cause of poor health and premature death, but evidence on the impact of changing levels of air pollution on mortality rates is scarce. A recent study in The BMJ shows that relocating to an area with improved air quality is associated with decreased mortality.

    • Ben Abbott
    Research Highlight Open Access
  • High levels of salt in the diet have been associated with high blood pressure and poor cardiovascular health. A recent trial in The New England Journal of Medicine investigates whether a salt substitute could decrease the rate of strokes, other cardiovascular events and deaths in a high risk population.

    • Ben Abbott
    Research Highlight Open Access
  • Reducing energy intake is known to result in weight loss. However, there is a need for real-world data on the impact of specific interventions to reduce energy intake. A recent trial in PLOS Medicine evaluated whether reductions in portion size and in the availability of high energy foods in workplace cafeterias could reduce energy consumption.

    • Katharine Barnes
    Research Highlight Open Access
  • Bast et al. discuss the early detection of ovarian cancer in the context of the recent UKCTOCS screening trial. The authors suggest potential reasons why the trial failed to achieve a reduction in mortality and outline next steps in the development of biomarkers and imaging modalities to detect ovarian cancer.

    • Robert C. Bast
    • Chae Young Han
    • Karen H. Lu
    Comment Open Access
  • Regenerative medicine may offer strategies to alleviate the debilitating symptoms of osteoarthritis and delay the time to joint replacement. In a study now published in Science Translational Medicine, Acevedo Rua and colleagues provide evidence of the therapeutic potential of autologous nasal chondrocyte-derived cartilage grafts in repairing arthritis-damaged knee joints.

    • Ben Abbott
    Research Highlight Open Access
  • Improvements in life expectancy have stalled over the last ten years in England, prompting research into the underlying causes. A recent study in The Lancet Public Health examines the relationship between cuts to local government funding and mortality in England.

    • Ben Abbott
    Research Highlight Open Access
  • Kurtovic et al. highlight some of the recent advances in the development and clinical evaluation of malaria vaccines. The authors outline key vaccine strategies and clinical trials, and discuss priorities for research into the development of an efficacious malaria vaccine.

    • Liriye Kurtovic
    • Linda Reiling
    • James G. Beeson
    Comment Open Access
  • Vokinger et al. discuss potential sources of bias in machine learning systems used in medicine. The authors propose solutions to mitigate bias across the different stages of model development, from data collection and preparation to model evaluation and application.

    • Kerstin N. Vokinger
    • Stefan Feuerriegel
    • Aaron S. Kesselheim
    Comment Open Access
  • KRAS is one of the most commonly mutated oncogenes in lung cancer but has long been considered undruggable. With the recent FDA approval of sotorasib, supported by positive phase II trial data now published in The New England Journal of Medicine, this is no longer the case.

    • Ben Abbott
    Research Highlight Open Access
  • Dengue virus is transmitted by Aedes aegypti mosquitoes and causes the disease known as dengue. In a trial published in The New England Journal of Medicine, Utarini and colleagues report that release of wolbachia-infected A. aegypti populations in a dengue endemic area reduces the number of symptomatic cases and of hospitalisations.

    • Andreia Cunha
    Research Highlight Open Access
  • Alwan discusses the lessons learnt over the past year regarding Long COVID, prolonged illness resulting from SARS-CoV-2 infection, and their implications for public health policy and disease management, drawing insight form her own lived experience, research, and advocacy work with Long COVID.

    • Nisreen A. Alwan
    Comment Open Access
  • Kundu discusses how artificial intelligence will transform medical practice and doctors’ training. The author explores the changing role of the clinician in the doctor-patient relationship, drawing parallels with the role of the pilot in light of increased automation in aviation.

    • Shinjini Kundu
    Comment Open Access
  • Amyloid-β peptide (Aβ) deposition in the brain is an early feature of Alzheimers’ disease. In a phase II clinical trial recently published in The New England Journal of Medicine, Mintun and colleagues report on the safety and efficacy of an antibody targeting Aβ peptide in amyloid plaques for the treatment of participants with early symptomatic Alzheimer’s disease.

    • Andreia Cunha
    Research Highlight Open Access
  • Communications Medicine is publishing its first articles today. We are an inclusive and open access medical journal that aims to facilitate and disseminate discovery that will promote health for all and improve the lives of those experiencing or living with disease.

    Editorial Open Access
  • In patients with high cholesterol and at risk of cardiovascular disease, inhibitors of PCSK9 are useful in lowering lipid levels but must be dosed regularly. A recent study in Nature by Munsunuru and colleagues explores the possibility of permanently disrupting PCSK9 expression via in vivo CRISPR gene editing in non-human primates, with long-lasting reductions in LDL cholesterol.

    • Ben Abbott
    Research Highlight Open Access
  • Kurtzhals et al. mark the centenary of the discovery of insulin by looking back at how this model protein has changed science and medicine. They discuss how lessons learned from insulin over the last one hundred years are shaping the present and future of protein-based therapies for chronic disease.

    • Peter Kurtzhals
    • Bernt Johan von Scholten
    • Stephen Charles Langford Gough
    Comment Open Access