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  • Mu et al. utilize a deep learning natural language processing model as part of an active learning approach to extract diagnostically relevant semantic information from bone marrow pathology synopses. Their findings demonstrate the potential for artificial intelligence in assisting clinicians in assessing, cataloging and triaging medical text datasets such as pathology synopses.

    • Youqing Mu
    • Hamid R. Tizhoosh
    • Clinton J. V. Campbell
    Article Open Access
  • Kundu discusses how artificial intelligence will transform medical practice and doctors’ training. The author explores the changing role of the clinician in the doctor-patient relationship, drawing parallels with the role of the pilot in light of increased automation in aviation.

    • Shinjini Kundu
    Comment Open Access
  • Amyloid-β peptide (Aβ) deposition in the brain is an early feature of Alzheimers’ disease. In a phase II clinical trial recently published in The New England Journal of Medicine, Mintun and colleagues report on the safety and efficacy of an antibody targeting Aβ peptide in amyloid plaques for the treatment of participants with early symptomatic Alzheimer’s disease.

    • Andreia Cunha
    Research Highlight Open Access
  • Communications Medicine is publishing its first articles today. We are an inclusive and open access medical journal that aims to facilitate and disseminate discovery that will promote health for all and improve the lives of those experiencing or living with disease.

    Editorial Open Access
  • In patients with high cholesterol and at risk of cardiovascular disease, inhibitors of PCSK9 are useful in lowering lipid levels but must be dosed regularly. A recent study in Nature by Munsunuru and colleagues explores the possibility of permanently disrupting PCSK9 expression via in vivo CRISPR gene editing in non-human primates, with long-lasting reductions in LDL cholesterol.

    • Ben Abbott
    Research Highlight Open Access
  • Kurtzhals et al. mark the centenary of the discovery of insulin by looking back at how this model protein has changed science and medicine. They discuss how lessons learned from insulin over the last one hundred years are shaping the present and future of protein-based therapies for chronic disease.

    • Peter Kurtzhals
    • Bernt Johan von Scholten
    • Stephen Charles Langford Gough
    Comment Open Access
  • Jun et al. evaluate sex-stratified clinical outcomes in two cohorts of patients hospitalized with COVID-19 in New York. While male sex risk is a risk factor for poor outcome in both cohorts – one from earlier and one from later on in the pandemic – some of the sex-specific risk factors observed initially are not observed later on.

    • Tomi Jun
    • Sharon Nirenberg
    • Kuan-lin Huang
    Article Open Access
  • MacLeod et al. evaluate the mechanical safety of 3D-printed personalised high tibial osteotomy (HTO) plates in an in silico clinical trial. Using this novel methodology, they find no increased risk of mechanical failure for personalised devices compared to conventional plates, supporting further studies to assess clinical outcomes in patients treated with personalised HTO.

    • Alisdair R. MacLeod
    • Nicholas Peckham
    • Harinderjit S. Gill
    Article Open Access
  • Knabl et al. perform a seroepidemiological study in the Austrian ski resort Ischgl, where a super-spreader event lead to a SARS-CoV-2 outbreak. Through mathematical modelling, they find that the subsequent decline in viral transmission was most likely a combined effect of high seropositivity and the implementation of non-pharmaceutical interventions.

    • Ludwig Knabl
    • Tanmay Mitra
    • Dorothee von Laer
    Article Open Access
  • Wulczyn et al. utilise a deep learning-based Gleason grading model to predict prostate cancer-specific mortality in a retrospective cohort of radical prostatectomy patients. Their model enables improved risk stratification compared to pathologists’ grading and demonstrates the potential for computational pathology in the management of prostate cancer.

    • Ellery Wulczyn
    • Kunal Nagpal
    • Craig H. Mermel
    Article Open Access