Next steps in the early detection of ovarian cancer

  • Robert C. Bast
  • Chae Young Han
  • Karen H. Lu
Comment

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  • High levels of salt in the diet have been associated with high blood pressure and poor cardiovascular health. A recent trial in The New England Journal of Medicine investigates whether a salt substitute could decrease the rate of strokes, other cardiovascular events and deaths in a high risk population.

    • Ben Abbott
    Research Highlight Open Access
  • Sachak-Patwa et al. estimate the risk of SARS-CoV-2 outbreaks in low prevalence settings following the removal of travel restrictions and other non-pharmaceutical interventions, with the Isle of Man and Israel as case studies. Using a branching process mathematical model, the authors show that even after a large proportion of the population is vaccinated, there remains a risk of local outbreaks from imported cases.

    • Rahil Sachak-Patwa
    • Helen M. Byrne
    • Robin N. Thompson
    Article Open Access
  • Reducing energy intake is known to result in weight loss. However, there is a need for real-world data on the impact of specific interventions to reduce energy intake. A recent trial in PLOS Medicine evaluated whether reductions in portion size and in the availability of high energy foods in workplace cafeterias could reduce energy consumption.

    • Katharine Barnes
    Research Highlight Open Access
  • Dalle Carbonare et al. perform a serology study in participants with a prior infection of SARS-CoV-2 and those who are SARS-CoV-2-naïve, who received two doses of the Pfizer-BioNTech BNT162b2 vaccine. After a single dose they observe a quicker recall of pseudovirus neutralization titres in previously-infected participants and a potent IgA response in both groups that was not associated with serum neutralization titres.

    • Luca Dalle Carbonare
    • Maria Teresa Valenti
    • Donato Zipeto
    Article Open Access
  • Plontke et al. report data on the preservation of vestibular function in a series of patients undergoing surgical removal of intracochlear tumors. Using objective clinical tests, the authors show that in most patients the vestibular system can function normally despite major surgical trauma to the cochlea.

    • Stefan K. Plontke
    • Torsten Rahne
    • Laura Fröhlich
    Article Open Access
  • Bast et al. discuss the early detection of ovarian cancer in the context of the recent UKCTOCS screening trial. The authors suggest potential reasons why the trial failed to achieve a reduction in mortality and outline next steps in the development of biomarkers and imaging modalities to detect ovarian cancer.

    • Robert C. Bast
    • Chae Young Han
    • Karen H. Lu
    Comment Open Access
  • Ying et al. conduct a multi-instrument Mendelian randomization study looking at the link between aging and COVID-19 risk. They observe an association between genetic variation implicated in longevity and decreased risk of COVID-19 infection and hospitalization, with Notch signaling and immune system development loci found to be important in aging-related COVID-19 risk.

    • Kejun Ying
    • Ranran Zhai
    • Vadim N. Gladyshev
    Article Open Access
  • Regenerative medicine may offer strategies to alleviate the debilitating symptoms of osteoarthritis and delay the time to joint replacement. In a study now published in Science Translational Medicine, Acevedo Rua and colleagues provide evidence of the therapeutic potential of autologous nasal chondrocyte-derived cartilage grafts in repairing arthritis-damaged knee joints.

    • Ben Abbott
    Research Highlight Open Access
  • Wong and Ngan et al. characterize the expression and structural variation of SARS-CoV-2 subgenomic RNAs (sgRNAs) in diagnostic specimens from symptomatic and asymptomatic COVID-19 patients. In a series of genomic and transcriptomic analyses, the authors observe reduced sgRNA expression and a distinct set of structural deletions in asymptomatic infections compared with symptomatic infections.

    • Chee Hong Wong
    • Chew Yee Ngan
    • Chia-Lin Wei
    Article Open Access