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  • Dearomative hydrogenation of benzoic acid and its derivatives is challenging to achieve selectively. Here, a highly active Pt/TiO2 catalyst which works in the presence of common catalyst poisons, including bi- and tri-benzoic acids, is described.

    • Miao Guo
    • Xiangtao Kong
    • Qihua Yang
    Article Open Access
  • Flow reactors have applications in reaction screening and optimisation, but typically operate in linear or radial configurations. Here a bench-top parallel flow synthesiser which distributes reagents between sixteen microreactors allows for rapid optimisation of chemical libraries, with uniform flow distribution even when clogging occurs.

    • Gwang-Noh Ahn
    • Brijesh M. Sharma
    • Dong-Pyo Kim
    Article Open Access
  • Superabsorbent materials can absorb many times their weight in water, but are commonly derived from petroleum. Here, acylation of coagulated potato protein concentrate or soluble potato protein fruit juice yields an effective, mould-resistant, and biodegradable superabsorbent polymer.

    • Antonio J. Capezza
    • Faraz Muneer
    • Eva Johansson
    Article Open Access
  • Mechanistic insight into enantioselective reactions at intrinsically chiral surfaces can be challenging to obtain. Here the catalytic activity of Pd1- and Pd3-terminated PdGa{111} surfaces is shown to differ substantially, with Pd1-terminated surfaces promoting on-surface azide– alkyne cycloadditions enantioand regioselectively.

    • Samuel Stolz
    • Michael Bauer
    • Roland Widmer
    Article Open Access
  • Ionizing radiation damage to DNA plays a fundamental role in cancer therapy, whereby water radiolysis effects are important to take into account. Here, near-ambient-pressure X-ray photoelectron-spectroscopy is used to directly measure DNA damage during irradiation in water and compared to that in a dry atmosphere.

    • Marc Benjamin Hahn
    • Paul M. Dietrich
    • Jörg Radnik
    Article Open Access
  • Halide salts exhibit complex radiation-induced reactions that are relevant in atmospheric chemistry, but detailed characterizations in high-level radiation fields are challenging to obtain. Here, the authors use a custom atomic force microscope to study alkali halide surface transformations in situ under 18 kGy/hr irradiation.

    • Shawn L. Riechers
    • Nikolay G. Petrik
    • Kevin M. Rosso
    Article Open Access
  • Interpreting ultrafast non-adiabatic vibronic processes of complex systems such as the excited benzene cation remains highly challenging. Here, a computational model is reported, where non-adiabatic events are seen far from a conical intersection and are controlled by electron dynamics involving a superposition of non-adjacent adiabatic states.

    • Thierry Tran
    • Graham A. Worth
    • Michael A. Robb
    Article Open Access
  • Chemical warfare agents and simulants are commonly detected with fluorescent sensing materials containing nitrogen-based groups, however these groups’ basicity can cause false positives in the presence of acids. Here, the authors disentangle the response of pyridyl-containing sensing materials to acid-containing and acid-free Sarin and simulants.

    • Shengqiang Fan
    • Genevieve H. Dennison
    • Paul E. Shaw
    Article Open Access
  • Electrocatalytic reactions depend on ion transport phenomena within the electric double layer, but the electrochemical response of single gas bubbles that form on catalyst surfaces remains unclear. Here, the authors use alternating current electrochemical impedance spectroscopy to detect a gateway through which ions can exchange between gas bubble surfaces and solid-state catalyst surfaces.

    • Veton Haziri
    • Tu Pham Tran Nha
    • Jean-François Boily
    Article Open Access
  • Existing routes to dibenzofurans have intrinsic regioselectivity, limiting the substitution patterns available in the products. Here a double 1,4-conjugate addition-annulation cascade between propargylamines and imidazolium methylides provides direct access to dibenzofurans with a complementary substitution pattern.

    • Xinwei He
    • Ruxue Li
    • Fuk Yee Kwong
    Article Open Access
  • Nidovirus RNA synthesis machineries catalyze nucleotide transfer, but characterization of this activity is limited using existing methods. Here the nucleotidyl transferase activity of SARSCoV-2 replicase proteins is characterized by mass spectrometry of GMP and UMP protein adducts, allowing identification of nucleotidylation sites in vitro.

    • Brian J. Conti
    • Andrew S. Leicht
    • Michael R. Sussman
    Article Open Access
  • Thioesters are often suggested to be key intermediates in primordial metabolism, but prebiotic CO2 fixation routes to thioesters remain elusive. Here, the authors show nickel sulfide, partially reduced to Ni(0) with realistic geoelectric potentials, facilitates thioester (S-methyl thioacetate) formation via CO2-to-CO electroreduction, followed by a CO-methanethiol reaction.

    • Norio Kitadai
    • Ryuhei Nakamura
    • Yoshi Oono
    Article Open Access
  • The formation of solid solutions can result in changes of relative stabilities of crystal polymorphs. Here, the elusive form III of benzamide is stabilized through solid solution formation with nicotinamide. It is shown, experimentally and computationally, how such thermodynamic switching allows for consistent and facile crystallization of the otherwise elusive benzamide form III.

    • Weronika Kras
    • Andrea Carletta
    • Aurora J. Cruz-Cabeza
    Article Open Access
  • Cyclohexane skeletal isomerisation is an important catalytic reaction, but generally involves a trade-off between catalyst activity and selectivity. Here zeolite-based catalysts improve the selectivity of this reaction towards methylcyclopentene while retaining good activity, attributed to the acidic, structural and morphological features of the optimized catalysts.

    • Hao Xu
    • Zhaofei Li
    • Hua Song
    Article Open Access
  • Chiral molecular recognition is critical in many natural processes, but probing the conformational landscape of chiral aromatic systems can be challenging. Here, high-resolution broadband rotational spectroscopy data is combined with quantum chemical computations to reveal the dynamic self-pairing topologies of the chiral molecule styrene oxide.

    • Sérgio R. Domingos
    • Cristóbal Pérez
    • Melanie Schnell
    Article Open Access
  • Hirudin is a widely studied model for folding of disulfide-rich proteins, which folds through a slow pathway with highly heterogeneous intermediates and scrambled isomers before it reaches its native state. Here the effect of native and non-native diselenide bridges on the kinetics, yield, and heterogeneity of hirudin folding are systematically explored.

    • Reem Mousa
    • Taghreed Hidmi
    • Norman Metanis
    Article Open Access