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    We're looking for a chemical biologist or organic chemist to join our team in London, Berlin, Shanghai or New York. No prior editorial experience is required — full on-the-job training will be provided. Application deadline is October 27th.

  • Rosa Adam Ortiz

    This month we thank Dr Rosa Adam Ortiz for her invaluable contributions to peer review. Dr Adam Ortiz works in the development of new catalysts for making organic transformations more sustainable. Her research interests are focused in both homogeneous and heterogeneous catalysis applied to CO2 valorization, as well as hydrogenation and hydrogen transfer reactions.

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  • Crystallization is observed in both nature and in the lab, and is critical to diverse areas of science and technology. Here, the author summarizes the theories that have been proposed to explain crystal growth from melts, and raises some open questions that remain.

    • Feier Hou
    Comment Open Access
  • Porous materials play a significant role in modern chemistry and materials science; despite recent scientific interest, they have a history dating back to antiquity. Here the authors provide a brief overview of the past that has contributed to their evolution.

    • Gregory S. Day
    • Hannah F. Drake
    • Matthew R. Ryder
    Comment Open Access
  • Aimed to decipher the levels of metabolites, metabolomics can now advance to unraveling their functionalities in various contexts. Here, the authors present the metabolite medicine concept, integrating classical metabolomics methods with advanced computational and structural tools to facilitate functional studies.

    • Shira Shaham-Niv
    • Sigal Rencus-Lazar
    • Ehud Gazit
    Comment Open Access
  • DNA-templated synthesis of chiral inorganic assemblies often requires chemical modification of the template. Now, a route exploiting the native chemistry of unmodified DNA origami templates provides access to 3D chiral assemblies.

    • Andrew J. Bissette
    Research Highlight Open Access
  • Water adsorption in soft nanoporous materials can trigger large-scale structural transitions and introduce new properties in the confined water phase. Here, we look at some of the outstanding questions in this lively field of research.

    • François-Xavier Coudert
    • Anne Boutin
    • Alain H. Fuchs
    Comment Open Access
  • The Hückel rule defines that monocyclic and planar conjugated systems containing [4n + 2] π electrons are aromatic. Here, the authors highlight boron species that feature a globally 4n π system, defying the Hückel rule, but nonetheless exhibit aromaticity.

    • Kei Ota
    • Rei Kinjo
    Comment Open Access
Open Questions in Chemistry

Open Questions in Chemistry

In spite of decades of research and the enormous progress made, chemists continue to grapple with poorly understood aspects of the world around us. This collection aims to uncover open questions across the breadth of the chemical sciences. Each Comment provides an overview of a focused field of research, identifies key open questions, and gives expert opinion on how challenges in answering these questions might be overcome.
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