Real-time observation of a correlation-driven sub 3 fs charge migration in ionised adenine

  • Erik P. Månsson
  • Simone Latini
  • Francesca Calegari
Article

Announcements

  • head shot of Rocio Mercado

    This month we thank Dr. Rocío Mercado from Astra Zeneca in Gothenburg, Sweden. She works at the intersection of computational chemistry and artificial intelligence for molecular discovery, with a current focus on small molecule drug design using deep generative models.

  • symbol image of question marks

    This collection aims to uncover open questions across the breadth of the chemical sciences. Each Comment provides an overview of a focused field of research, identifies key open questions, and gives expert opinion on how challenges in answering these questions might be overcome.

Advertisement

  • Organic microlaser sensors are highly promising for chemical vapor detection due to their chemical versatility, but their poor stabilities are hampering applications. Here the authors report the synthesis and lasing properties of a dye that is self-assembled into microwires exhibiting a strong acid vapor response and good stability.

    • Zheming Chen
    • Chenghu Dai
    • Chuang Zhang
    Article Open Access
  • Glycomimetics are structural mimics of carbohydrates that can replicate their biological activity but have improved drug-like properties. Here, using proline-catalysed α-halogenation/aldol cascades, carbohydrate building blocks are readily assembled and then diversified into glycomimetics including imino- and carbasugars.

    • Michael Meanwell
    • Gaelen Fehr
    • Robert Britton
    Article Open Access
  • Hyperpolarized metabolic contrast agents for magnetic resonance imaging can provide non-invasive and realtime information on tissue specific aberrant metabolism, but producing and handling them is highly demanding because of their short lifetime. Here a solid sample extraction, storage, and transport technique allows disconnecting production from end-user sites handling, as well as hour-long lifetimes of the agents.

    • Andrea Capozzi
    • Jan Kilund
    • Jan Henrik Ardenkjær-Larsen
    Article Open Access
  • Guanidinium-containing macromolecules, such as arginine-rich peptides, have peculiar properties in their interactions with membranes, including efficient translocation. Here the authors show that cationic gold nanoparticles functionalized with guanidinium groups can specifically and nondisruptively interact with phospholipid bilayer membranes.

    • Lucía Morillas-Becerril
    • Sebastian Franco-Ulloa
    • Fabrizio Mancin
    Article Open Access
  • Mass spectrometry can be used for structural determination of N-glycans, but commonly requires prior derivatisation or comparison to a library of standards. Here logically-derived sequence tandem mass spectrometry allows for assignment of native N-glycans by analysis of successive fragmentation patterns without derivatisation and standards.

    • Chia Yen Liew
    • Chu-Chun Yen
    • Chi-Kung Ni
    Article Open Access
  • The process of thermally activated delayed fluorescence (TADF) converts non-radiative triplet states into emissive singlet states. Herein we outline the fundamentals of TADF, some of the recent progress in understanding the key material properties responsible for promoting TADF and finally discuss some remaining challenges for the  potential applications of this phenomenon.

    • Julien Eng
    • Thomas J. Penfold
    Comment Open Access
  • Superheavy elements are ideal for furthering our understanding of relativistic effects and how they affect physicochemical properties of heavy elements. In this comment, the author discusses the role of chemistry in the synthesis of new elements before addressing the future challenges concerning the chemical characterization of superheavy elements.

    • Patrick Steinegger
    Comment Open Access
  • Ultrafast singlet fission has the potential to facilitate highly efficient photovoltaics through the multiplication of excitons in organic molecular architectures. Here, we consider the interplay of molecular structure and intermolecular coupling toward enabling ultrafast singlet fission and discuss open questions in the field.

    • Justin C. Johnson
    Comment Open Access
  • Preorganization is an effective strategy for f-element separation, but the complexity of extractant synthesis hinders large-scale application. Here the authors discuss an alternative strategy induced by in situ self-assembly that borrows principles of multivalent cooperativity from Nature to separate f-elements.

    • Lixi Chen
    • Shuao Wang
    Comment Open Access
  • Lewis acid additives such as aluminium can enable fascinating new reactivity in transition metal catalysts, but few catalytic intermediates have been characterised. Now, a nickel-aluminium pincer complex offers new mechanistic insight into transmetalation, and new potential for reactivity.

    • Andrew J. Bissette
    Research Highlight Open Access
Open Questions in Chemistry

Open Questions in Chemistry

In spite of decades of research and the enormous progress made, chemists continue to grapple with poorly understood aspects of the world around us. This collection aims to uncover open questions across the breadth of the chemical sciences. Each Comment provides an overview of a focused field of research, identifies key open questions, and gives expert opinion on how challenges in answering these questions might be overcome.
Collection

Nature Careers

Events