Bismuth organic frameworks exhibiting enhanced phosphorescence

  • Jin Young Koo
  • Changmin Lee
  • Hee Cheul Choi


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    This month we thank Dr Claudia Contini for her invaluable contributions to peer review. Dr Contini's research interests lie in bottom-up synthetic biology, focusing on the design of synthetic life-like systems that mimic biological properties and functions with high potential in biotechnological and biomedical applications.

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  • Small changes in protein structure can have pronounced effects on protein–protein interactions, but quantifying this has only recently become possible. Now, the binding landscapes of three homologous enzyme–inhibitor complexes are quantified and shown to depend on whether the inhibitor binds its natural target or a structurally similar protein.

    • Andrew J. Bissette
    Research Highlight Open Access
  • Understanding heat conduction in solids is fundamental to the design of high-performing thermoelectric materials. Now, a combined computational and experimental study shows how local order paired with long-range disorder leads to a desirable reduction in thermal conductivity while retaining high electron mobility in the Zintl phase Eu2ZnSb2.

    • Teresa S. Ortner
    Research Highlight Open Access
  • Crystallization is observed in both nature and in the lab, and is critical to diverse areas of science and technology. Here, the author summarizes the theories that have been proposed to explain crystal growth from melts, and raises some open questions that remain.

    • Feier Hou
    Comment Open Access
  • Porous materials play a significant role in modern chemistry and materials science; despite recent scientific interest, they have a history dating back to antiquity. Here the authors provide a brief overview of the past that has contributed to their evolution.

    • Gregory S. Day
    • Hannah F. Drake
    • Matthew R. Ryder
    Comment Open Access
  • Aimed to decipher the levels of metabolites, metabolomics can now advance to unraveling their functionalities in various contexts. Here, the authors present the metabolite medicine concept, integrating classical metabolomics methods with advanced computational and structural tools to facilitate functional studies.

    • Shira Shaham-Niv
    • Sigal Rencus-Lazar
    • Ehud Gazit
    Comment Open Access
  • DNA-templated synthesis of chiral inorganic assemblies often requires chemical modification of the template. Now, a route exploiting the native chemistry of unmodified DNA origami templates provides access to 3D chiral assemblies.

    • Andrew J. Bissette
    Research Highlight Open Access
Open Questions in Chemistry

Open Questions in Chemistry

In spite of decades of research and the enormous progress made, chemists continue to grapple with poorly understood aspects of the world around us. This collection aims to uncover open questions across the breadth of the chemical sciences. Each Comment provides an overview of a focused field of research, identifies key open questions, and gives expert opinion on how challenges in answering these questions might be overcome.

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