Reviews & Analysis

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  • In this Perspective, the authors discuss how state-of-the-art three-dimensional mapping technologies such as fine-scale terrestrial laser scanning can help us understand the theories of plant forms.

    • Yi Lin
    • Juha Hyyppä
    Perspective Open Access
  • Colzato, Beste and Hommel discuss the possibility of a theoretical framework which considers the positive potential of selective cognitive dysfunction. They suggest a two-step approach to identify the potential and develop the corresponding training.

    • Lorenza S. Colzato
    • Christian Beste
    • Bernhard Hommel
    Perspective Open Access
  • The study of animal societies has been increasingly explored with social network analysis. In this Perspective, the importance of these networks in directing conservation efforts of fish is highlighted.

    • David Villegas-Ríos
    • David M. P. Jacoby
    • Johann Mourier
    Perspective Open Access
  • Kozlowski, Crook, and Ku review current state-of-the-art techniques in culturing and manipulating organoids without the use of EHS-tumor-derived matrix, the most popular of which is Matrigel by Corning. They cover organoid-based applications of different matrix types, ranging from natural sources (decellularized ECM, purified ECM proteins, polysaccharides), synthetic sources (e.g. PEG-based), and recombinant peptide-based systems.

    • Mark T. Kozlowski
    • Christiana J. Crook
    • Hsun Teresa Ku
    Review Article Open Access
  • Okabe and Uchiyama provide their perspective on the work performed during the past decade on intracellular thermometry and major challenges of the field. Describing the importance of the temperature at both large and cellular scale, they highlight the possible contribution of intracellular thermometry to new biological studies.

    • Kohki Okabe
    • Seiichi Uchiyama
    Perspective Open Access
  • Zhang et al. describe metrics for evaluating glycaemic variability (GV) in clinical practice and summarize the role and related mechanisms of GV in diabetic neuropathy, including cardiovascular autonomic neuropathy, diabetic peripheral neuropathy and cognitive impairment. They aim to stimulate ideas for the treatment of diabetic neuropathy.

    • Xiaochun Zhang
    • Xue Yang
    • Chunsheng Zhu
    Review Article Open Access
  • This perspective by Ziegler et al. explores the impact of mitochondria-endoplasmic reticulum contacts (MERCs) biology on cellular senescence. The authors also explore the potential impacts of MERCs perturbation and how this relates to the increase in cellular senescence observed in common age-related diseases.

    • Dorian V. Ziegler
    • Nadine Martin
    • David Bernard
    Perspective Open Access
  • Garbarino et al review recent experimental and epidemiological developments regarding immune responses to sleep deprivation and consider the role for the sleep deprivation induced immune changes in increasing the risk for chronic diseases.

    • Sergio Garbarino
    • Paola Lanteri
    • Egeria Scoditti
    Review Article Open Access
  • In this Review, Bhat et al. highlight ways to mine crop haplotypes and apply them for dissecting complex traits and genomics-assisted breeding (GAB) approaches. This Review presents new avenues to discover superior haplotypes and assemble them in targeted manner in crop breeding for faster delivery of high-yielding cultivars with better adaptation to future climates.

    • Javaid Akhter Bhat
    • Deyue Yu
    • Rajeev K. Varshney
    Review Article Open Access
  • Melo, Maasch and de la Fuente-Nunez review the current practices in use of artificial intelligence in the discovery of antibiotics and antimicrobials. They also provide details about the best-practices that should be engaged with during computational drug discovery, including open science and reproducibility.

    • Marcelo C. R. Melo
    • Jacqueline R. M. A. Maasch
    • Cesar de la Fuente-Nunez
    Review Article Open Access
  • In this review Widden and Placzek synthesize studies characterizing the influence that myeloid cell leukemia-1 (MCL1) has on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broader scope that it plays in cellular homeostasis regulation. They discuss which pathways are likely to be impacted by emerging MCL1 inhibitors, as well as highlight non-cancerous disease states that could deploy BH3-mimetics in the future.

    • Hayley Widden
    • William J. Placzek
    Review Article Open Access
  • In this Review, Laura Martinez-Vidal et al. summarize current knowledge of factors affecting extracellular matrix (ECM) remodeling in the context of pathological mechanical changes to tissue properties. They focus on the importance of research on tissue stiffness to the development of diagnostic tools and therapies to treat urological disease.

    • Laura Martinez-Vidal
    • Valentina Murdica
    • Massimo Alfano
    Review Article Open Access
  • Golesorkhi et al. discuss recent literature on intrinsic neural timescales, their potential role in input processing including computational mechanism, and how they relate to mental features, psychiatric disorders and artificial intelligence.

    • Mehrshad Golesorkhi
    • Javier Gomez-Pilar
    • Georg Northoff
    Perspective Open Access
  • In this Perspective, Diane Dickel and colleagues review recent progress and opportunities in applying single-cell sequencing and microfluidics methods to plants. The authors highlight the need for new tools developed with plants in mind, and advocate for the creation of a centralized, open-access database to house plant single-cell data.

    • Benjamin Cole
    • Dominique Bergmann
    • Diane E. Dickel
    Perspective Open Access