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Modelling based on fMRI data obtained during more than 100 different cognitive tasks reveals that representation and decoding are preserved across the cortex, cerebellum, and subcortex
Analyses of learning mechanisms, pupillometry, and fMRI data from healthy participants in a cognitive estimation task reveal neural dynamics related to how self-efficacy beliefs are formed, as well as how this process is impacted by emotions.
Fusion of ACE2 to IgM-Fc results in hexameric ACE2-IgM-Fc proteins with potent virus neutralization efficiency of patient-isolated SARS-CoV and SARS-CoV-2 variants.
Fibrin gel-based 3D co-culture models with human-iPSC differentiated dopaminergic or glutamatergic neurons and astrocytes are shown to be functional using biosensors and can be scaled up for high-throughput assays.
Cell heterogeneity in the mouse anterior cruciate ligament (ACL) and medial collateral ligament (MCL) is demonstrated using single-cell analysis with three types of fibroblasts identified, expressing Col14a1, Col12a1, or Col22a1.
A combination of live imaging and immunofluorescence on donor islet cells uncover an anti-correlation of enzyme-bound NAD(P)H and insulin secretion power.
Ternary cyclodextrin- arginine- ciprofloxacin complexes show improved stability and increased efficacy against P. aeruginosa in Galleria mellonella worms.
An open-source framework combines deep learning and permutations of gene interaction neural networks to detect complex gene–gene interactions and their significance in contributions to phenotypes.
A microfluidic system combines the capture, co-incubation, time-lapse imaging, and gene expression profiling of doublets to measure the distances between cells and associated transcriptional profiles due to cell–cell interactions.
Using two different comparisons of varying saccade types, a systematic analysis of saccade-related activity in superior colliculus (SC) neurons demonstrates that SC motor bursts do not dictate the kinematics of rapid eye movements.
Murine chondrocyte hypertrophy was found to require IGF2-regulated bioenergetic reprogramming, in which glucose utilization shifts from glycolysis to oxidative phosphorylation as chondrocytes mature.
A technological approach combines transport, guiding and focusing of individual bacteria from solution to ultrathin membrane resonators for dry mass determination of single cells with accuracy within 1% and throughput of 20 cells/min.
The conserved division protein DivIC in the human pathogen Staphylococcus aureus controls cell division through the recruitment of major cell wall synthesis enzymes to the division site.
Voltage imaging and machine learning reveal that human breast cancer cells exhibit voltage fluctuations absent in non-tumorigenic breast cells, beginning to shed light on the bioelectric properties of cancer processes.
In a mouse model of endometriosis, niclosamide is found to have potential therapeutic value through its fine regulations of the dynamic progression of macrophages.
Piezoresponse force microscopy reveals abnormal piezoelectric and mechanical properties of collagen fibrils in brittle bone disease, highlighting the importance of collagen piezoelectricity in intrafibrillar mineralization.
An agonistic Siglec-6 antibody that binds to a membrane-distal domain of Siglec-6 is identified that induces inhibition and reduction of mast cells and suppresses anaphylaxis in a humanized mouse model.
Microglia-targeting AAV vectors are created which can be utilized to study microglial pathophysiology and microglia-targeted therapies in mice, especially in the regions of striatum and cerebellar cortex.