Research articles

Comprehensive characterization of the glucose-6-phosphate dehydrogenase (G6PD) Meyer variant that contains an R219G substitution suggests compromised dimerization, stability, and catalytic activity of the mutant enzyme causes chronic hemolysis.

A scRNA-seq study reveals the dynamic landscape of the intestinal cellular microenvironment during radiation-induced intestine injury and regeneration.

A combination of slice physiology, in vivo optogenetics, and behavioral analyses shows that the cortical-cortical connection between bilateral anterior cingulate cortex facilitates pain perception and enhanced anxiety-like behaviors associated with acute and chronic pain in adult mice.

Long-read sequencing of fish and plant samples demonstrate that ethanol suitably preserves field-collected specimens for genome assembly of organisms, reducing the necessity for cryogenic storage.

An integrated approach using phylogeographic data, climate modelling, and network analysis unlocks insights into the post-glacial expansion of the sand fly Phlebotomus mascittii in Europe and suggests two potential (parallel) dispersal routes.

An MEG study on semantic processing of concepts in a silent picture naming task indicates that the brain gradually accumulates information before reaching a plateau.

Skeletal muscle aging is characterized by the loss of muscle mass and function, mainly attributed to the atrophy of glycolytic fibers. The underlying mechanisms driving this impairment were investigated in unbiased approaches in a glycolytic muscle.

This work discovers that transcranial photobiomodulation enhances lymphatic clearance of inflammatory factors from the brain of diabetic mice, providing the reverse of microglial dysfunction and amelioration of physiological disorders.

Protein crotonylation, as one of post-translational modifications (PTMs), can be further modified, herein named post-PTM (PPM) by a monooxygenase in Streptomyces to regulate substrate protein turnover and cell physiology.

The MetaInvert database provides draft genome assemblies for 232 soil invertebrate species, representing 14 common groups and 94 families, that will aid in the discovery and management of soil biodiversity.

The fibroproliferative properties of keloids are regulated by the HEDGEHOG-GLI1 signaling pathway, and inhibition of this pathway reduced the number of keloid stem-like cells, expression of keloid-specific genes, and the keloid fibrosis phenotype.

A multi-parameter real time tracking setup that synchronizes intestinal circular and longitudinal muscle contractions, intraluminal pressure, and volume recordings to decipher the parameters influencing peristalsis and luminal discharge in mice.

Development of a CRISPRi gene modulation platform to target key cardiac ion channels in human iPSC-CMs offers correlation of function measured by all-optical electrophysiology and molecular underpinnings.

Double-stranded RNA acts both preventatively and curatively against myrtle rust disease in perennial plants. Spray treatment reduces disease coverage and improves long-term plant health, offering a solution to long-standing myrtle rust epidemics.

A chromosome-level genome for the Silkie chicken (Gallus gallus domesticus) provides insight into both the basis of fibromelanosis in these animals and, more broadly, unresolved genes in genome assemblies for related chicken subspecies.

Multiple behavioral and functional adaptations enable the unique water living spider Argyroneta aquatica to apply its silk attachment discs for anchoring its dragline within an air layer around its spinnerets under water.

Amylin facilitates infant care and oxytocin’s inverse agonist reduces physical contact with non-infant family member, so these signaling mediate social interaction in family in complementary manner.

An unbiased primary sensory neuron screen identifies the chemotherapeutic agent bortezomib as a potent TRPV1 sensitizer. Such long-term sensitization could lead to axonal death and sensory loss, a major symptom of bortezomib-induced neuropathy.

This article presents a hitherto unknown role of a-Synuclein protein to function as a Pickering agent for TDP-43-RNA biomolecular condensates to emulsify them towards heterotypic amyloid fibrils.

Carbon/nitrogen stoichiometry of ectomycorrhizas varies with the fungal symbiont and determines the plant carbon and nitrogen resource allocation to species-rich ectomycorrhizal communities.