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Using patient-derived induced pluripotent stem cells, the authors show that the transcription factor GFI1B and the lysine demethylase KDM1A/LSD1 promote gene programs while repressing those involved in myeloid differentiation.
The methyltransferase TrSAM from Trichoderma reesei is suggested to have an important role in regulating the expression of cellulase and heterologous proteins initiated by cbh1 promotor through interacting with ACE1R383.
A Perspective on how the tools of behavioral science and the emerging field of diverse intelligence help to understand decision-making of cellular collectives in evolutionary and biomedical contexts.
Pan-cancer analysis of kindlin genes on patient genomic data reveals a distinct pattern of kindlin activity. Our analysis suggests kindlins as mechanochemical connector of major cancer hallmark pathways.
A study of opportunity on deep-sea Ridge Flank Hydrothermal Systems, which host low-temperature, chemically insignificant venting, suggests that warmer temperatures are a contributing factor to changing community composition and higher biodiversity.
An epigenetic study on free-ranging spotted hyenas (Crocuta crocuta) suggests that genes are differentially methylated between high-ranking and low-ranking females (cubs and adults) which may reflect rank-specific differences in access to resources.
We present a new method for the efficient segmentation and 3D shape analysis of mitochondrial inner components from FIBSEM images using multiplanar UNET and persistent homology.
Expanded intronic G4C2 repeats in C9orf72 cause ALS/FTD. GR dipeptide repeats produced in C9orf72 ALS/FTD co-aggregate with Kap2 in neurons, affecting survival. Upregulating Kapβ2 may mitigate neurotoxicity, a potential therapy for C9orf72-ALS/FTD.
The long-read metagenome of rice phyllosphere microbiome shows novel complete chromosomes, plasmids, bacteriophages, and novel bacterial species. Notably one complete chromosome belongs to the difficult-to-culture bacterium CandidatusSaccharibacteria.
Osteoarthritis (OA) affects over 500 million adults worldwide. Signal transducer and activator of transcription 1 can increase complement C3 expression after IL-1β stimulation, and STAT1 inhibition can prevent OA pathogenesis in guinea pigs.
Both PKC phosphorylation and elevated calcium levels are required for TRPM5 activation, the phosphorylation is crucial for channel-evoked currents at physiological membrane potentials.
Mutational analysis of the flagellar export apparatus protein FlhA suggests that the conserved GYXLI motif of FlhA, together with the cytoplasmic ATPase complex, strictly regulate the order of flagellar protein export.
Aerodynamic modeling based on the primitive, early Eocene bat Onychonycteris strongly supports a gliding transition to powered flight in mammals, which is facilitated under the hyperdense atmospheric conditions here inferred for the fossil age.
The promoter PSCBV-YZ2060 cloned from the sugarcane bacilliform virus is shown to be induced by drought in sugarcane and Arabidopsis plants and is a potential alternative promoter for genetic engineering of drought-resistant transgenic crops.
Nutrition shapes animal growth and survival. E. coli-derived vitamin B6 is crucial for reversing developmental arrest in C. elegans fed with probiotic Lactiplantibacillus plantarum, independently of FoxO/DAF-16 activation.
This review introduces the basic principle of fluorescence and two-photon excitation microscopy that is aimed at novice and advanced microscopists highlighting current techniques, trends, and practical guides for live imaging optimization.
Analysis of M3-Gq coupling utilized fulllength proteins and techniques like HDX-MS & NanoBiT assay, revealing potential binding interfaces in the preassembled and agonistactive complexes and critical regions for the complex formation and Gq activation.
Maternal RNA transcription plays an important role in maintaining vasculature in mouse placental development, associated with regulating gene expression, imprinting status and DNA methylation in the Dlk1-Dio3 imprinted domain.
The output of a nanomachine powered by an array of myosin molecules purified from the skeletal muscle is fed to a stochastic model, which provides a self-consistent estimate of all the mechanokinetic parameters of the motor ensemble.