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The chemokine receptors CCR2 and CCR7 synergistically regulate recruitment of inflammatory monocytes from the bone marrow to the brain of mice infected with La Crosse and Herpes Simplex virus.
Presenting a deconvolution algorithm to dissect the bulk proteome by leveraging the information shared between the transcriptome and proteome, the output can be used for further downstream analyses, such as cs-protein Quantitative Trait Loci (cspQTL) mapping and cell type-specific pathology.
A phase-contrast CT study of obstructive biliary disease suggests that the evolution of bile infarct and the formation of infarct-sinusoidal microchannels promote the disease progression.
Nucleic acids-based drugs aim to fix the genetic problem at its source and emerge as a promising new class of drugs. Recent advances in this field enabled their approval for the treatment of orphan genetic diseases for which no cure was available.
This study reports the direct detection of ribonucleotides embedded in DNA molecules by Oxford Nanopore sequencing, based on ribonucleotides-induced alterations in basecalling features, currents, and dwell times.
Exosomes from rats with obstructive sleep apnoea aggravate metabolic dysfunction-associated steatotic liver disease by delivering the lncRNA TCONS_00039830 to hepatocytes and regulating Smad2 expression through targeting miR-455-3p.
Epileptic seizure is one of the symptoms in patients with NGLY1 deficiency, a congenital disorder of deglycosylation. Here the authors show suppressive effects of oxytocin on seizure-like behaviors in a mouse model of NGLY1 deficiency.
PAV-104, a small molecule, potently inhibits SARS-CoV-2 replication in human airway epithelial cells by disrupting viral particle assembly and release. These findings suggest that PAV-104 holds significant promise as a therapeutic for COVID-19.
This study, utilizing deep learning to model semantic saturation, shows its tie to repetitive visual stimuli processing by the primary visual cortex, suggesting a bottom-up neurocognitive process.
A single cell TCRseq method for dogs that robustly detects TCR expression suggests reannotation of some non-functional VJ genes between diverse between diverse repertoires of healthy dogs and expanded repertoires in malignancies.
Infants with heightened vs. lower likelihood of developing autism spectrum disorder exhibit different functional connectivity patterns in the salience network. These patterns predict sensory and social behaviors at 1 year of age.
A study in Uganda found that local extirpation of a mineral-rich tree species used in tobacco farming forced wildlife to obtain minerals by eating bat guano, in which 27 eukaryotic viruses were identified, including a novel betacoronavirus.
A blood exchange system reveals that leukemia cells clear faster in the blood than circulating tumor cells from solid tumors and that clearance rates can vary in response to tumor and treatment status.
Rummagene is a search engine for gene sets. It was created by extracting human and mouse gene sets from supporting materials of > 120,000 biomedical research publications.
Two diacylglycerol acyltransferases were shown to be differently regulated in large yellow croaker and rainbow trout. While DGAT1 is increased upon oleic acid treatment more in croaker than in trout, DGAT2 showed no significant expression difference.
This study maps the peripheral immune landscape of childhood Sjogren’s disease at single-cell level, providing immune and molecular characterizations that necessitate a better understanding in the etiology of the rare autoimmune disease.
This fMRI study unveils how specific amygdala subregions and associated brain circuits undergo structural changes over time, highlighting the intricacies of brain plasticity and its link to cognitive and emotional processes.