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March 31st marks Transgender Day of Visibility, an opportunity to celebrate and elevate the achievements of the transgender community. As part of our annual celebration of Transgender Day of Visibility, we reached out to Leland Graber and Dr. Ezra Kottler, two early-career transgender biologists who shared their own experiences and perspectives on improving support systems for the transgender research community.
A workflow for 3D characterization of the mouse small intestine with optical projection tomography allows the identification of sparsely-distributed regions of interest in large volumes while retaining compatibility with high-resolution microscopy modalities.
A genomic analysis of 147 pediatric acute myeloid leukemia patients identifies extensive gene fusion events and mutations that expand our understanding of the genetic complexities of this cancer.
Calpain2a, a calcium-dependent protease, acts as a negative regulator of antibacterial and antiviral immunity in teleost fish by interacting with TRAF6 to promote TRAF6 degradation and inhibit TRAF6 dimerization and auto-ubiquitination.
Analysing genetic data from 1,655 men with non-obstructive azoospermia (NOA) reveals four independent loss-of-function variants in DDX3Y, suggesting that it is a key gene in the AZFa region and should be considered in diagnostic workflows for NOA.
Bayesian modeling of anatomical lesion patterns and clinical language outcomes in a cohort of 1401 stroke patients identifies sex-biased lesion-outcome effects after stroke.
The TCRDivER algorithm incorporates both clone size and sequence similarity of T cell receptors (TCR) to reveal greater complexity in TCR repertoires and novel TCR repertoire traits due to a nonlinear correlation of the two.
Phylogenetic comparative analysis using data of 1,638 species of angiosperms and gymnosperms suggests that the evolution of plant adaptation to critical environmental change in water availability across global climates is dependent on mycorrhizas.
ATP-independent amyloid-β chaperone L-PGDS disaggregates corneal amyloids in surgically excised human cornea of TGFBI-related corneal dystrophy patients by recognizing and releasing structurally frustrated regions.
The combined analysis of single cell and bulk epigenetic datasets and multiple sclerosis GWAS reveals the enrichment of genetic susceptibility signals in B cells and monocyte-microglia cell types.
A wide-field imaging system uses birefringence to efficiently permit quantitative fluorophore concentration mapping, with clear relevance for neurosurgery.
Dynamic docking simulations reveal the interactions and conformational changes of the intrinsically disordered region of Bim and its cryptic binding site in Bcl-xL, a pro-survival protein involved in cancer progression.
Human-specific SINE-VNTR-Alu (SVA) retrotransposons in neurodevelopmental genes CDK5RAP2 and SCN8A repress their expression to delay neuronal maturation. SVA-lncRNA AK057321 binds these SVAs to release gene repression and drive neuronal maturation.
Learning song from two ‘tutors’ at different points in development permanently alters neural activity in auditory processing and learning regions in zebra finches.
AAV1-T593K (AAV1*) is a custom-made viral vector that enables efficient transduction and manipulation of quail neurons, thereby expanding the toolkit for avian neuroscience research.
