Browse Articles

  • Article
    | Open Access

    Julien Brechbühl et al. show that the Grueneberg ganglion olfactory subsystem is necessary for deciphering the threatening or safe qualities of unfamiliar food based on olfactory or social signals, respectively, in mice. These results highlight the role of this subsystem in optimizing decision-making strategies related to food preference by integrating environmental cues.

    • Julien Brechbühl
    • , Aurélie de Vallière
    • , Dean Wood
    • , Monique Nenniger Tosato
    •  & Marie-Christine Broillet
  • Article
    | Open Access

    Ronghui Song et al. demonstrate that a lawsone (2-hydroxy-1,4-naphthoquinone)-based compound decreases the drug resistance of methicillin-resistant Staphylococcus aureus much better than conventional antibiotics. This study provides insights into the design and action mechanism of effective antibiotics that overcome the antibiotic resistance of bacteria.

    • Ronghui Song
    • , Bing Yu
    • , Dirk Friedrich
    • , Junfeng Li
    • , Hao Shen
    • , Harald Krautscheid
    • , Songping D. Huang
    •  & Min-Ho Kim
  • Article
    | Open Access

    Shao et al. show that a bacterial symbiont drives its fungal host to biosynthesize a polyketide antimicrobial, spiromarmycin, fending off their competitors. They find that the spiromarmycin biosynthetic machinery is encoded by the fungal host. This study provides insights into the evolution of marine microbial diversity.

    • Mingwei Shao
    • , Changli Sun
    • , Xiaoxiao Liu
    • , Xiaoxue Wang
    • , Wenli Li
    • , Xiaoyi Wei
    • , Qinglian Li
    •  & Jianhua Ju
  • Article
    | Open Access

    With NMR and MD simulations, Li, Chen et al. comprehensively probe the effects of osmolytes on hydrogen bond formation in proteins. They show that polyol and sugar osmolytes weaken hydrogen bonding between the protein and solvent while strengthening those within the protein.

    • Jingwen Li
    • , Jingfei Chen
    • , Liaoyuan An
    • , Xiaoxiang Yuan
    •  & Lishan Yao
  • Article
    | Open Access

    Gen Sobue, Masao Nagasaki and colleagues report a genome-wide association study for amyotrophic lateral sclerosis (ALS) in a large, multi-ethnic cohort comprising Japanese, Chinese, and European ancestry populations. They find a significant association to variants within the ACSL5 gene and identify novel associations with 4 additional genes using a gene-based approach.

    • Ryoichi Nakamura
    • , Kazuharu Misawa
    • , Genki Tohnai
    • , Masahiro Nakatochi
    • , Sho Furuhashi
    • , Naoki Atsuta
    • , Naoki Hayashi
    • , Daichi Yokoi
    • , Hazuki Watanabe
    • , Hirohisa Watanabe
    • , Masahisa Katsuno
    • , Yuishin Izumi
    • , Kazuaki Kanai
    • , Nobutaka Hattori
    • , Mitsuya Morita
    • , Akira Taniguchi
    • , Osamu Kano
    • , Masaya Oda
    • , Kazumoto Shibuya
    • , Satoshi Kuwabara
    • , Naoki Suzuki
    • , Masashi Aoki
    • , Yasuyuki Ohta
    • , Toru Yamashita
    • , Koji Abe
    • , Rina Hashimoto
    • , Ikuko Aiba
    • , Koichi Okamoto
    • , Kouichi Mizoguchi
    • , Kazuko Hasegawa
    • , Yohei Okada
    • , Tomohiko Ishihara
    • , Osamu Onodera
    • , Kenji Nakashima
    • , Ryuji Kaji
    • , Yoichiro Kamatani
    • , Shiro Ikegawa
    • , Yukihide Momozawa
    • , Michiaki Kubo
    • , Noriko Ishida
    • , Naoko Minegishi
    • , Masao Nagasaki
    •  & Gen Sobue
  • Research Highlight
    | Open Access

    While polygyny is common among vertebrates, polygyny with mate fidelity has not yet been demonstrated in amphibians. A recent study by Fábio de Sá and colleagues shows that single male saxicolous frogs share a breeding territory with two females and mate multiple times with them over the course of a breeding season. These authors attribute the evolution of this mating system to the intense competition for territories and mates when access to these resources is scarce.

    • Caitlin Karniski
  • Article
    | Open Access

    Kevin Neil et al. quantified horizontal gene transfer rates for 13 conjugative plasmids in the mouse gut microbiota to identify those that might be useful for developing microbiome editing technologies. They find that the Incl-family plasmid TP114 has a nearly 100% transfer efficiency in the mouse gut.

    • Kevin Neil
    • , Nancy Allard
    • , Frédéric Grenier
    • , Vincent Burrus
    •  & Sébastien Rodrigue
  • Article
    | Open Access

    Using T-jump 2D-IR spectroscopy, Zhang et al. show that DNA minor-groove binder Hoechst 33258 strongly destabilizes its complex with DNA (H-DNA). This study suggests that the association of H-DNA is a concerted process, where Hoechst 33258 cooperates with DNA single strands in forming H-DNA.

    • Xin-Xing Zhang
    • , Shelby L. Brantley
    • , Steven A. Corcelli
    •  & Andrei Tokmakoff
  • Article
    | Open Access

    Krishnan et al. find that CCR1 ligands CCL6 and CCL23 secreted by murine and human macrophages, respectively, enhance metastatic colonization of ovarian cancer cells to the omentum in manner dependent on chemokine receptor 1 (CCR1). This study suggests that targeting CCR1 or CCL23 in ovarian cancer may be a therapeutic strategy.

    • Venkatesh Krishnan
    • , Supreeti Tallapragada
    • , Bruce Schaar
    • , Kalika Kamat
    • , Anita M. Chanana
    • , Yue Zhang
    • , Sonia Patel
    • , Vinita Parkash
    • , Carrie Rinker-Schaeffer
    • , Ann K. Folkins
    • , Erinn B. Rankin
    •  & Oliver Dorigo
  • Article
    | Open Access

    Miller et al. present a disassociated rhamphotheca of a Cretaceous bird, which sheds light on the diet and developmental biology of some of the earliest birds. Exceptionally preserved fossils are rare but when soft tissue is preserved it can provide insight into the anatomy and behavior of extinct organisms.

    • Case Vincent Miller
    • , Michael Pittman
    • , Thomas G. Kaye
    • , Xiaoli Wang
    • , Jen A. Bright
    •  & Xiaoting Zheng
  • Article
    | Open Access

    Van de Wiel et al. show that expression of a dominant negative subunit of connexin26, which has a reduced sensitivity for carbon dioxide, in glial cells of the caudal parapyramidal area reduces tidal volume and minute respiration. These findings suggest that direct sensing of carbon dioxide by connexin26 is important for the chemosensory control of breathing.

    • Joseph van de Wiel
    • , Louise Meigh
    • , Amol Bhandare
    • , Jonathan Cook
    • , Sarbjit Nijjar
    • , Robert Huckstepp
    •  & Nicholas Dale
  • Article
    | Open Access

    Matsuda et al. examine size correlations in body traits of proboscis monkeys, known for their enlarged noses, and find that while body size and nose size is positively correlated in both sexes, body size is negatively correlated with canine size in males. This study serves as an example of interactions between sexual and natural selection, and morphological traits that act as weapons and adornments.

    • Ikki Matsuda
    • , Danica J. Stark
    • , Diana A. Ramirez Saldivar
    • , Augustine Tuuga
    • , Senthilvel K. S. S. Nathan
    • , Benoit Goossens
    • , Carel P. van Schaik
    •  & Hiroki Koda
  • Article
    | Open Access

    Abs et al. develop a multi-scale model to explain the evolution of microbial cooperation driving the decomposition of soil organic matter. Their model shows that the evolutionary stability of decomposition depends on a combination of local extinctions, microbial dispersal, and limited soil diffusivity.

    • Elsa Abs
    • , Hélène Leman
    •  & Régis Ferrière
  • Article
    | Open Access

    Li et al. report surface fouling of the early Cambrian animal Vetulicola by small, encrusting tubular organisms from the Chengjiang biota of Yunnan Province in China, a ~518 million year old marine deposit. These specimens provide evidence for early escalation of intimate ecologies and biofouling as a previously unrecognised component of the evolution of early marine ecosystems.

    • Yujing Li
    • , Mark Williams
    • , Thomas H. P. Harvey
    • , Fan Wei
    • , Yang Zhao
    • , Jin Guo
    • , Sarah Gabbott
    • , Tom Fletcher
    • , Xianguang Hou
    •  & Peiyun Cong
  • Article
    | Open Access

    Yamanaka et al exploit the fact that immunomodulatory drugs (IMiDs) interacts with the E3 ligase CRL4-CRBN to induce degradation of alternative substrates including Sal-like protein 4 (SALL4) to develop a degradation system that targets proteins tagged with a SALL4-like degron. This tool can degrade proteins at various cellular locations.

    • Satoshi Yamanaka
    • , Yuki Shoya
    • , Saya Matsuoka
    • , Hisayo Nishida-Fukuda
    • , Norio Shibata
    •  & Tatsuya Sawasaki
  • Article
    | Open Access

    Jia, Wu, Kim et al. show that cyanidin-3-O-glucoside (C3G), a major dietary anthocyanin, functions as a ligand for PPARalpha to regulate energy metabolism and insulin sensitivity in mouse models of obesity and diabetes. This study suggests that C3G slows down the metabolism of glucose, making it a promising therapeutic agent.

    • Yaoyao Jia
    • , Chunyan Wu
    • , Young-Suk Kim
    • , Seung Ok Yang
    • , Yeonji Kim
    • , Ji-Sun Kim
    • , Mi-Young Jeong
    • , Ji Hae Lee
    • , Bobae Kim
    • , Soyoung Lee
    • , Hyun-Seok Oh
    • , Jia Kim
    • , Min-Young So
    • , Ye Eun Yoon
    • , Trung Thanh Thach
    • , Tai Hyun Park
    •  & Sung-Joon Lee
  • Article
    | Open Access

    Matsushita et al. demonstrate the evolution of DHA biosynthetic mechanisms in four species of flatfish as some of them colonised freshwater environments. Their analyses show independent changes to the biosynthetic pathways as a way to overcome the lack of exogenous DHA that would typically be available from prey in the marine environment.

    • Yoshiyuki Matsushita
    • , Kaho Miyoshi
    • , Naoki Kabeya
    • , Shuwa Sanada
    • , Ryosuke Yazawa
    • , Yutaka Haga
    • , Shuichi Satoh
    • , Yoji Yamamoto
    • , Carlos Augusto Strüssmann
    • , John Adam Luckenbach
    •  & Goro Yoshizaki
  • Article
    | Open Access

    Koh, Islam, Ye et al. describe lipid profiles of Aedes aegypti mosquitoes bearing mono- or dual-infections of Wolbachia (wMel) and dengue virus serotype 3 (DENV3), finding that virus modulation dominates the dual-infection lipid profile and that cardiolipins support DENV3 and Wolbachia replication. This study suggests that direct competition for lipids do not underlie Wolbachia-mediated virus blocking.

    • Cassandra Koh
    • , M. Nurul Islam
    • , Yixin H. Ye
    • , Nunya Chotiwan
    • , Barbara Graham
    • , John T. Belisle
    • , Konstantinos A. Kouremenos
    • , Saravanan Dayalan
    • , Dedreia L. Tull
    • , Stephan Klatt
    • , Rushika Perera
    •  & Elizabeth A. McGraw
  • Article
    | Open Access

    Tomohiro Imamura et al. report that a WD40 protein REBC, which differs from the trichome formation-linked WD40 protein TTG1, plays a critical role in epidermal bladder cell formation in quinoa. They further reveal a protective role of the epidermal bladder cells against the shoot apex damage by abiotic stress, especially salt stress, shedding light on the mechanisms underlying epidermal bladder cell formation and function.

    • Tomohiro Imamura
    • , Yasuo Yasui
    • , Hironori Koga
    • , Hiroki Takagi
    • , Akira Abe
    • , Kanako Nishizawa
    • , Nobuyuki Mizuno
    • , Shinya Ohki
    • , Hiroharu Mizukoshi
    •  & Masashi Mori
  • Article
    | Open Access

    In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • , Natalie G. Farny
    • , Traci Haddock-Angelli
    • , Vinoo Selvarajah
    • , Geoff S. Baldwin
    • , Russell Buckley-Taylor
    • , Markus Gershater
    • , Daisuke Kiga
    • , John Marken
    • , Vishal Sanchania
    • , Abigail Sison
    • , Christopher T. Workman
    • , Meryem Pehlivan
    • , Biel Badia Roige
    • , Tiu Aarnio
    • , Samu Kivisto
    • , Jessica Koski
    • , Leevi Lehtonen
    • , Denise Pezzutto
    • , Pauliina Rautanen
    • , Weixin Bian
    • , Zhiyuan Hu
    • , Zhihao Liu
    • , Zi Liu
    • , Liang Ma
    • , Luyao Pan
    • , Zichen Qin
    • , Huichao Wang
    • , Xiangxuan Wang
    • , Hao Xu
    • , Xia Xu
    • , Yorgo El Moubayed
    • , Shan Dong
    • , Choco Fang
    • , Hanker He
    • , Henry He
    • , Fangliang Huang
    • , Ruyi Shi
    • , Cassie Tang
    • , Christian Tang
    • , Shirly Xu
    • , Calvin Yan
    • , Natalia Bartzoka
    • , Eleni Kanata
    • , Maria Kapsokefalou
    • , Xanthi-Leda Katopodi
    • , Eleni Kostadima
    • , Ioannis V. Kostopoulos
    • , Stylianos Kotzastratis
    • , Antonios E. Koutelidakis
    • , Vasilios Krokos
    • , Maria Litsa
    • , Ioannis Ntekas
    • , Panagiotis Spatharas
    • , Ourania E. Tsitsilonis
    • , Anastasia Zerva
    • , Vidhya Annem
    • , Eli Cone
    • , Noel Elias
    • , Shreya Gupta
    • , Kendrick Lam
    • , Anna Tutuianu
    • , Dennis M. Mishler
    • , Bibiana Toro
    • , Akinwumi Akinfenwa
    • , Frank Burns
    • , Heydy Herbert
    • , Melissa Jones
    • , Sarah Laun
    • , Shikei Morrison
    • , Zion Smith
    • , Zhao Peng
    • , Zhou Ziwei
    • , Rui Deng
    • , Yilin Huang
    • , Tingyue Li
    • , Yingqi Ma
    • , Zhiyuan Shen
    • , Chenxi Wang
    • , Yuyao Wang
    • , Tianyan Zhao
    • , Yusen Lang
    • , Yuteng Liang
    • , Xueyao Wang
    • , Yi Wu
    • , Dror Aizik
    • , Sagi Angel
    • , Einan Farhi
    • , Nitzan Keidar
    • , Eden Oser
    • , Mor Pasi
    • , Jorn Kalinowski
    • , Matthias Otto
    • , Johannes Ruhnau
    • , Hande Cubukcu
    • , Mehmet Ali Hoskan
    • , Ilayda Senyuz
    • , Jordi Chi
    • , Antoni Planas Sauter
    • , Magda Faijes Simona
    • , Sumin Byun
    • , Sungwoo Cho
    • , Goeun Kim
    • , Yeonjae Lee
    • , Sangwu Lim
    • , Hanyeol Yang
    • , Tian Xin
    • , Zhang Yaxi
    • , Peng Zhao
    • , Weitang Han
    • , Fa He
    • , Yuna He
    • , Nuonan Li
    • , Xiaofan Luo
    • , Cheng Boxuan
    • , Hu Jiaqi
    • , Yang Liangjian
    • , Li Wanji
    • , Chen Xinguang
    • , Liu Xinyu
    • , Zishi Wu
    • , Yukun Xi
    • , Xilin Yang
    • , Yuchen Yang
    • , Zhuoyi Yang
    • , Yihao Zhang
    • , Yuezhang Zhou
    • , Yue Peng
    • , Liu Yadi
    • , Shaobo Yang
    • , Jiang Yuanxu
    • , Kecheng Zhang
    • , Doris Abraham
    • , Theresa Heger
    • , Cass Leach
    • , Kevin Lorch
    • , Linda Luo
    • , Alex Gaudi
    • , Anthony Ho
    • , Morris Huang
    • , Christine Kim
    • , Luxcia Kugathasan
    • , Kevin Lam
    • , Catherine Pan
    • , Ariel Qi
    • , Cathy Yan
    • , Kaitlin Schaaf
    • , Cassandra Sillner
    • , Ryan Coates
    • , Hannah Elliott
    • , Emily Heath
    • , Evie McShane
    • , Geraint Parry
    • , Ali Tariq
    • , Sophie Thomas
    • , Ching-Wei Chen
    • , Yu-Hong Cheng
    • , Chia-Wei Hsu
    • , Chin-Hsuan Liao
    • , Wei-Ting Liu
    • , Yu-Cheng Tang
    • , Yu-Hsin Tang
    • , Zon En Yang
    • , Liu Jian
    • , Caidian Li
    • , Chenyi Lin
    • , Guozheng Ran
    • , Zhouyan Run
    • , Weiyu Ting
    • , Zhangxiang Yong
    • , Liuhong Yu
    • , Andrea Clausen Lind
    • , Axel Norberg
    • , Amanda Olmin
    • , Jacob Sjolin
    • , Agnes Torell
    • , Cecilia Trivellin
    • , Francisco Zorrilla
    • , Philip Gorter de Vries
    • , Haolun Cheng
    • , Jiarong Peng
    • , Zhenyu Xiong
    • , Dina Altarawneh
    • , Sayeda Sakina Amir
    • , Sondoss Hassan
    • , Annette Vincent
    • , Ben Costa
    • , Isabella Gallegos
    • , Mitch Hale
    • , Matt Sonnier
    • , Kathleen Whalen
    • , Max Elikan
    • , Sean Kim
    • , Jaewon You
    • , Rahul Rambhatla
    • , Ashwin Viswanathan
    • , Hong Tian
    • , Huandi Xu
    • , Wanli Zhang
    • , Shuyao Zhou
    • , Liu Jiamiao
    • , Xiao Jiaqi
    • , Darilyn Craw
    • , Marley Goetz
    • , Neil Rettedal
    • , Hayden Yarbrough
    • , Christopher Ahlgren
    • , Brett Guadagnino
    • , James Guenther
    • , Juilanne Huynh
    • , Zhien He
    • , Huan Liu
    • , Yuansheng Liu
    • , Mingbo Qu
    • , Li Song
    • , Chao Yang
    • , Jun Yang
    • , Xianqi Yin
    • , Yuanzhen Zhang
    • , Jianan Zhou
    • , Lihan Zi
    • , Zhu Jinyu
    • , Xu Kang
    • , Peng Xilei
    • , Han Xue
    • , Shu Xun
    • , Priyanka Babu
    • , Arushi Dogra
    • , Pranav Thokachichu
    • , David Faurdal
    • , Joen Haahr Jensen
    • , Jacob Mejlsted
    • , Lina Nielsen
    • , Tenna Rasmussen
    • , Jennifer Denter
    • , Kai Husnatter
    • , Ylenia Longo
    • , Juan Carlos Luzuriaga
    • , Eduardo Moncayo
    • , Natalia Torres Moreira
    • , Jennifer Tapia
    • , Tang Dingyue
    • , Zhao Jingjing
    • , Xu Wenhao
    • , Teng Xinyu
    • , Hong Xiujing
    • , Jackson DeKloe
    • , Ben Astles
    • , Ugne Baronaite
    • , Inga Grazulyte
    • , Michael Hwang
    • , Yibo Pang
    • , Michael Andrew Crone
    • , Reza Hosseini
    • , Moustafa Houmani
    • , Daniel Zadeh
    • , Violetta Zanotti
    • , Oliver Andreas Baltensperger
    • , Eline Yafele Bijman
    • , Elisa Garulli
    • , Jan Lukas Krusemann
    • , Adriano Martinelli
    • , Antonio Martinez
    • , Tobias Vornholt
    • , Monteil Camille
    • , Ahavi Paul
    • , Emily Browne
    • , Daniel Barber James Gilman
    • , Amy Hewitt
    • , Sophie Hodson
    • , Ingebjorg Holmedal
    • , Fiona Kennedy
    • , Juliana Sackey
    • , Selina Beck
    • , Franziska Eidloth
    • , Markus Imgold
    • , Anna Matheis
    • , Tanja Meerbrei
    • , David Ruscher
    • , Marco Schaeftlein
    • , Zhu Hanrong
    • , Mitchell Wan
    • , Leijie Dai
    • , Kaifeng Jin
    • , Sihan Wang
    • , Xin Wang
    • , Yi Wang
    • , Yifan Wang
    • , Chenhai Wu
    • , Zixuan Zhang
    • , Yineng Zhou
    • , Liu Xinyu
    • , Zeng Zirong
    • , Rehmat Babar
    • , Mathew Brewer
    • , Christina Clodomir
    • , Laura Das Neves
    • , Amanda Iwuogo
    • , Ari Jones
    • , Cara Jones
    • , Julia Kelly
    • , Gloria Kim
    • , Jessica Siemer
    • , Yash Yadav
    • , Yuichiro Ikagawa
    • , Tatsuki Isogai
    • , Ryo Niwa
    • , Celine Aubry
    • , William Briand
    • , Annick Jacq
    • , Sylvie Lautru
    • , Britany Marta
    • , Clemence Maupu
    • , Xavier Ollessa-Daragon
    • , Kenn Papadopoulo
    • , Mahnaz Sabeta Azad
    • , Wei Kuangyi
    • , Yao Xiu
    • , Chenghao Yang
    • , Aditya Iyer
    • , Rianne Prins
    • , Phillip Yesley
    • , Fang Lichi
    • , Chen Zi Xuan
    • , Kyuhee Jo
    • , Mikyung Park
    • , Seunghyun Park
    • , Hojun Yoo
    • , Nele Burckhardt
    • , Lea Daniels
    • , Bjarne Klopprogge
    • , Dustin Kruger
    • , Oda-Emilia Meyfarth
    • , Lisa Putthoff
    • , Dominika Wawrzyniak
    • , Xinyi Hu
    • , Yunyi Wang
    • , Lior Badash
    • , Amichai Baichman-Kass
    • , Alon Barshap
    • , Yonatan Friedman
    • , Eliya Milshtein
    • , Omri Vardi
    • , Shan Dong
    • , Yining Gu
    • , Yuanzhe Pei
    • , Ruyi Shi
    • , Fan Yang
    • , Jinshu Yang
    • , Xueqian Zhu
    • , Lam Kai Ching
    • , Law Hiu Ching
    • , Ng Tsz Chun
    • , Yu Man Hin
    • , Lai Tsz Hong
    • , Chan Wing Lam
    • , Yiu Choi Lam
    • , Cheah Matthew
    • , Cheng Tsz Ngo
    • , Yun Shuan
    • , Chan Tsey Wan
    • , Tsui Shing Yan
    • , Chong Yuk Yee
    • , Tam Chi Yu
    • , Yuen Wai Yu
    • , Chung Tsun Ho Anson
    • , Lee Sze Choi
    • , Cheung Man Chun
    • , Chan Lok Hin
    • , Wong Chung Hin
    • , Ng Sze Ho
    • , Leung Chung Yin Jay
    • , Lai Man Wai Katherine
    • , Wong Carol Kin-ning
    • , Lee Hong Kiu
    • , Cheng Chak Kong
    • , Leung Chung Wai
    • , Yeung Wing Yan
    • , Wong Tsz Yeung
    • , Lee Ka Yin
    • , Tsui Shing Yan Grace
    • , Lam Kai Ching Joe
    • , Ng Tsz Chun Kenneth
    • , Cheah Matthew Yun Shuan
    • , Ferdinan Aldo
    • , Chung Him Pang
    • , Kam Pang So
    • , Hei Man Wong
    • , Lai Tsz Ching
    • , Luk Hau Ching
    • , Ip Ning Fung
    • , Yam Shing Fung
    • , Lee Chi Hong
    • , Hsiu Ou Ning
    • , Jonathan Cheng Hon Sang
    • , Yeung Hoi Lam Elsa
    • , Chan Yick Hei
    • , Lo Ho Sing
    • , Choi Seong Wang
    • , Yiheng Gu
    • , Ziyue Rong
    • , Haoyue Song
    • , Pengying Wang
    • , Yuefei Wang
    • , Yan Chen
    • , Hao Qiu
    • , Haotian Ren
    • , Ziyang Xiao
    • , Heng Heng
    • , Xichen Rao
    • , Ruonan Tian
    • , Shalini S. Deb
    • , Yash Laxman Kamble
    • , Ninad Kumbhojkar
    • , Bhargav Patel
    • , Supriya Prakash
    • , Shamlan M. S. Reshamwala
    • , Poorva Taskar
    • , Gokul
    • , Adwaith B. Uday
    • , Anubhav Basu
    • , Rishi Gandhi
    • , Jatin Khaimani
    • , Arundhati Khenwar
    • , Sandeep Raut
    • , Tejas Somvanshi
    • , Diptatanu Das
    • , Souvik Ghosh
    • , Hrishika Rai
    • , Nithishwer Mouroug Anand
    • , Ashwin Kumar Jainarayanan
    • , Pranshu Kalson
    • , Devang Haresh Liya
    • , Vibhu Mishra
    • , Sveekruth Sheshagiri Pai
    • , Madhav Pitaliya
    • , Yash Rana
    • , Ravineet Yadav
    • , Neha Arora
    • , Vasu Arora
    • , Shubham Jain
    • , Abhilash Patel
    • , Saksham Sharma
    • , Priyanka Singh
    • , Anushya Goenka
    • , Rishabh Jain
    • , Aryaman Jha
    • , Adarsh Kumar
    • , Abhinav Soni
    • , Sathvik Ananthakrishnan
    • , Velvizhi Devi
    • , Mohammed Faidh
    • , Guhan Jayaraman
    • , M. Sagar Kittur
    • , Nitish R. Mahapatra
    • , Sarvesh Menon
    • , Anantha Barathi Muthukrishnan
    • , B. P. Kailash
    • , Burhanuddin Sabuwala
    • , Mousami Shinde
    • , Sankalpa Venkatraghavan
    • , Weijia Liu
    • , Zhoudi Miao
    • , Tian Wang
    • , Yaling Wang
    • , Shuyan Zhang
    • , Ruochen Chai
    • , Yubin Ge
    • , Ali Hou
    • , Fangqi Liu
    • , Xutong Liu
    • , Jiangjiao Mao
    • , Zihao Wang
    • , Haimeng Yu
    • , Hetian Yuan
    • , Yang Zhan
    • , Anna Ries
    • , Chiara Wolfbeisz
    • , Toshihiro Kanaya
    • , Yusuke Kawasaki
    • , Tatuya Maruo
    • , Yuya Mori
    • , Takehito Satoh
    • , Anthony Chau
    • , Wai Yan Chu
    • , Anatoliy Markiv
    • , Marcos Vega-Hazas Marti
    • , Maria Jose Ramos Medina
    • , Deeksha Raju
    • , Shubhankar Sinha
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    • , Chengwu Shen
    • , Tinh Son
    • , Julia Urban
    • , Yashna Verma
    • , Hanmi Zhou
    • , Shan Dong
    • , Zhengguo Hao
    • , Yi Kuang
    • , Ting Liu
    • , Rui Zhou
    • , Beck Arruda
    • , Natalie Farny
    • , Mei Hao
    • , Camille Pearce
    • , Alex Rebello
    • , Arth Sharma
    • , Kylie Sumner
    • , Bailey Sweet
    • , Junliang Lin
    • , Du Mengtao
    • , Fan Peiyao
    • , Fang Xinlei
    • , Niangui Cai
    • , Junhong Chen
    • , Yousi Fu
    • , Yunyun Hu
    • , Ye Qiang
    • , Qiupeng Wang
    • , Ruofan Yang
    • , Chen Yucheng
    • , Jiyang Zheng
    • , Kevin Chang
    • , Cecily Gao
    • , Farren Isaacs
    • , Kevin Li
    • , Ricardo Moscoso
    • , Jaymin Patel
    • , Lauren Telesz
    • , Alice Tirad
    • , Qinhao Cao
    • , Xinhua Feng
    • , Yinjing Lu
    • , Xianyin Zhang
    • , Xuanhao Zhou
    • , Dongchang Sun
    • , Zhe Yuan
    •  & Jiajie Zhou
  • Article
    | Open Access

    Schuhmacher, Beldar et al. design a super-substrate peptide based on the substrate sequence specificity of the SETD2 protein lysine methyltransferase. SETD2 methylates this super-substrate 290-fold more efficiently than the original H3K36 peptide. This study illustrates that substrate sequence design can improve the activity of protein lysine methyltransferases.

    • Maren Kirstin Schuhmacher
    • , Serap Beldar
    • , Mina S. Khella
    • , Alexander Bröhm
    • , Jan Ludwig
    • , Wolfram Tempel
    • , Sara Weirich
    • , Jinrong Min
    •  & Albert Jeltsch
  • Article
    | Open Access

    Fabrizio Pizzagalli et al. study the genetics factors that regulate cortical folding patterning in the brain. They use in vivo brain MRI datasets from around the world and report the reliability and heritability of sulcal morphometric characteristics for 61 sulci per hemisphere of the human brain. They uncover hemisphere-specific genetic influences on the cerebral cortex.

    • Fabrizio Pizzagalli
    • , Guillaume Auzias
    • , Qifan Yang
    • , Samuel R. Mathias
    • , Joshua Faskowitz
    • , Joshua D. Boyd
    • , Armand Amini
    • , Denis Rivière
    • , Katie L. McMahon
    • , Greig I. de Zubicaray
    • , Nicholas G. Martin
    • , Jean-François Mangin
    • , David C. Glahn
    • , John Blangero
    • , Margaret J. Wright
    • , Paul M. Thompson
    • , Peter Kochunov
    •  & Neda Jahanshad
  • Article
    | Open Access

    Though modern species are on the brink of extinction, rhinos and tapirs have a diverse fossil record. Six new species of fossil rhinos reported by Bin Bai et al. show that rhinos evolved even earlier than previously thought, perhaps linked to the close, humid environments of the Early Eocene Climatic Optimum.

    • Bin Bai
    • , Jin Meng
    • , Chi Zhang
    • , Yan-Xin Gong
    •  & Yuan-Qing Wang
  • Article
    | Open Access

    Chung et al. introduce Pre-Pro as a loss-less pre-processor incorporating a fast dimension-reduction (2SDR) de-noiser to enhance 2D classification. Implementing it in representative classification algorithm like RELION and ISAC, they further demonstrate faster classification, improved quality of class-average images and yield of good particles which improve the final resolution.

    • Szu-Chi Chung
    • , Hsin-Hung Lin
    • , Po-Yao Niu
    • , Shih-Hsin Huang
    • , I-Ping Tu
    •  & Wei-Hau Chang
  • Article
    | Open Access

    Thodberg et al. report the first step of the synthesis of cyanogenic glycosides, a plant defense mechanism, by a Flavin-dependent monooxygenase (FOS1) in ferns, revealing convergent evolution of biosynthesis across the plant kingdom. The authors isolate FOS1 as a catalytically active dimer and demonstrate that it catalyzes the formation of N-hydroxylated amino acids.

    • Sara Thodberg
    • , Mette Sørensen
    • , Matteo Bellucci
    • , Christoph Crocoll
    • , Amalie Kofoed Bendtsen
    • , David Ralph Nelson
    • , Mohammed Saddik Motawia
    • , Birger Lindberg Møller
    •  & Elizabeth Heather Jakobsen Neilson
  • Article
    | Open Access

    Through analyses of olfactory receptors in single-cell RNA sequencing dataset from different cancers, Kalra, Mittal et al. find that the number and expression levels of olfactory receptors vary by differentiation status. The study provides insights into an under-appreciated role for olfactory receptors in cancer pathogenesis.

    • Siddhant Kalra
    • , Aayushi Mittal
    • , Krishan Gupta
    • , Vrinda Singhal
    • , Anku Gupta
    • , Tripti Mishra
    • , Srivatsava Naidu
    • , Debarka Sengupta
    •  & Gaurav Ahuja
  • Article
    | Open Access

    Li et al develop an algorithm they call Deviating gene Expression Profiling Tumor Heterogeneity (DEPTH) to evaluate levels of intratumour heterogeneity (ITH) at the mRNA level based on the asynchrony of transcriptome alterations in tumors. Analysing TCGA and GEO data-sets, they show that this method is simpler, more effective, and more robust than other ITH scoring algorithms.

    • Mengyuan Li
    • , Zhilan Zhang
    • , Lin Li
    •  & Xiaosheng Wang
  • Article
    | Open Access

    Ermakova et al. report four Noggin genes in lampreys and using phylogenetics, gene synteny analysis, and in situ hybridization, suggest that the Noggin gene underwent two rounds of duplication and evolved specific functions before the divergence of vertebrate and lamprey lineages. These findings offer insight into early vertebrate genome and developmental evolution.

    • Galina V. Ermakova
    • , Alexander V. Kucheryavyy
    • , Andrey G. Zaraisky
    •  & Andrey V. Bayramov
  • Article
    | Open Access

    Wang et al. perform RNA-Seq on pineapple floral samples and also use previously published RNA-Seq datasets to generate tissue- and stage-specific transcriptomic profiles. The authors use weighted gene co-expression network analysis to identify gene networks, bringing insight to underlying pineapple reproductive organ growth.

    • Lulu Wang
    • , Yi Li
    • , Xingyue Jin
    • , Liping Liu
    • , Xiaozhuan Dai
    • , Yanhui Liu
    • , Lihua Zhao
    • , Ping Zheng
    • , Xiaomei Wang
    • , Yeqiang Liu
    • , Deshu Lin
    •  & Yuan Qin
  • Article
    | Open Access

    Yuhua Fu et al. develop a CNN model that integrates multi-omics information to prioritize candidate genes of objective traits. Their model performs well when applied to important livestock non-model animals like Sus scrofa. Finally, the authors present ISwine, an online comprehensive knowledgebase which includes all published swine omics data to facilitate the integration of heterogeneous data.

    • Yuhua Fu
    • , Jingya Xu
    • , Zhenshuang Tang
    • , Lu Wang
    • , Dong Yin
    • , Yu Fan
    • , Dongdong Zhang
    • , Fei Deng
    • , Yanping Zhang
    • , Haohao Zhang
    • , Haiyan Wang
    • , Wenhui Xing
    • , Lilin Yin
    • , Shilin Zhu
    • , Mengjin Zhu
    • , Mei Yu
    • , Xinyun Li
    • , Xiaolei Liu
    • , Xiaohui Yuan
    •  & Shuhong Zhao
  • Article
    | Open Access

    Olson et al. report the crystal structures of the N-terminal five domains of human cation-independent mannose 6-phosphate receptor (CI-MPR) suggesting a binding- and pH-induced conformational change. Their data may explain how high-affinity carbohydrate-binding is achieved through allosteric domain cooperativity.

    • Linda J. Olson
    • , Sandeep K. Misra
    • , Mayumi Ishihara
    • , Kevin P. Battaile
    • , Oliver C. Grant
    • , Amika Sood
    • , Robert J. Woods
    • , Jung-Ja P. Kim
    • , Michael Tiemeyer
    • , Gang Ren
    • , Joshua S. Sharp
    •  & Nancy M. Dahms
  • Article
    | Open Access

    Using Nrf2 knockout mice, Suzuki, Uruno, Yumoto et al. show that space travel activates Nrf2 signaling, which contributes to the weight gain of mice by regulating fat metabolism of white adipose tissues. This study provides insights into potential interventions to mitigate stresses that accompany space travels.

    • Takafumi Suzuki
    • , Akira Uruno
    • , Akane Yumoto
    • , Keiko Taguchi
    • , Mikiko Suzuki
    • , Nobuhiko Harada
    • , Rie Ryoke
    • , Eriko Naganuma
    • , Nanae Osanai
    • , Aya Goto
    • , Hiromi Suda
    • , Ryan Browne
    • , Akihito Otsuki
    • , Fumiki Katsuoka
    • , Michael Zorzi
    • , Takahiro Yamazaki
    • , Daisuke Saigusa
    • , Seizo Koshiba
    • , Takashi Nakamura
    • , Satoshi Fukumoto
    • , Hironobu Ikehata
    • , Keizo Nishikawa
    • , Norio Suzuki
    • , Ikuo Hirano
    • , Ritsuko Shimizu
    • , Tetsuya Oishi
    • , Hozumi Motohashi
    • , Hirona Tsubouchi
    • , Risa Okada
    • , Takashi Kudo
    • , Michihiko Shimomura
    • , Thomas W. Kensler
    • , Hiroyasu Mizuno
    • , Masaki Shirakawa
    • , Satoru Takahashi
    • , Dai Shiba
    •  & Masayuki Yamamoto
  • Article
    | Open Access

    Using arginine-immobilized magnetic nanobeads, Cho et al. show that glucokinase, the key regulator of glucose-stimulated insulin secretion, binds L-arginine, which protects glucokinase from ubiquitination-mediated degradation while inducing insulin secretion. This study provides mechanistic insights into how L-arginine increases insulin production.

    • Jaeyong Cho
    • , Yukio Horikawa
    • , Mayumi Enya
    • , Jun Takeda
    • , Yoichi Imai
    • , Yumi Imai
    • , Hiroshi Handa
    •  & Takeshi Imai
  • Research Highlight
    | Open Access

    The origins of Ornithodira (the last common ancestor of dinosaurs, pterosaurs, and their descendants) are yet to be resolved, and have the potential to inform on the diversification of some of the most intriguing ecologies and body forms to evolve in reptiles. A recent discovery of an extremely small ornithodiran archosaur by Christian Kammerer and colleagues is indicative of a miniaturisation event early in the evolution of Ornithodira. This raises questions about the evolution of characters associated with small body forms in these groups, such as flight and body surface integument.

    • Luke R. Grinham
  • Article
    | Open Access

    Akiyo Natsubori et al. use a genetically encoded sensor to measure intracellular ATP levels in mouse cortical excitatory neurons in vivo. They show cortex-wide variations in ATP levels across sleep-wake states, and that cerebral energy metabolism does not always meet neuronal energy demands.

    • Akiyo Natsubori
    • , Tomomi Tsunematsu
    • , Akihiro Karashima
    • , Hiromi Imamura
    • , Naoya Kabe
    • , Andrea Trevisiol
    • , Johannes Hirrlinger
    • , Tohru Kodama
    • , Tomomi Sanagi
    • , Kazuto Masamoto
    • , Norio Takata
    • , Klaus-Armin Nave
    • , Ko Matsui
    • , Kenji F. Tanaka
    •  & Makoto Honda
  • Article
    | Open Access

    Rohani et al show that converting human pluripotent stem cells (hPSCs) to the naïve state enhances hPSC manufacturing. Further, through transcriptomics, the expression of epigenetic regulators, metabolomics, and cell-surface protein marker analyses, they indicate a potentially important role for the stirred bioreactor’s mechanical environment in maintaining naïve-like pluripotency.

    • Leili Rohani
    • , Breanna S. Borys
    • , Golsa Razian
    • , Pooyan Naghsh
    • , Shiying Liu
    • , Adiv A. Johnson
    • , Pranav Machiraju
    • , Heidrun Holland
    • , Ian A. Lewis
    • , Ryan A. Groves
    • , Derek Toms
    • , Paul M. K. Gordon
    • , Joyce W. Li
    • , Tania So
    • , Tiffany Dang
    • , Michael S. Kallos
    •  & Derrick E. Rancourt
  • Article
    | Open Access

    Kawasaki et al. identified three water-soluble astaxanthin binding proteins (AstaP) orthologs, AstaP-orange2, AstaP-pink1, and AstaP-pink2, in the eukaryotic microalga Scenedesmus sp. Oki-4N, grown under stress conditions. Their detailed characterisation showed that each AstaP ortholog had a specific absorption feature, but all were capable of quenching single oxygen. They envision that AstaP accumulation might have protective functions against photooxidative stress.

    • Shinji Kawasaki
    • , Keita Yamazaki
    • , Tohya Nishikata
    • , Taichiro Ishige
    • , Hiroki Toyoshima
    •  & Ami Miyata
  • Article
    | Open Access

    Liu et al. present evidence that carbon fixation in Ulva prolifera takes place via a combination of C3 and C4 pathways in combination with the enzyme carbonic anhydrase. The active and multi-faceted carbon acquisition strategy in U. prolifera is advantageous for the formation of massive blooms as the thick floating mats are subject to intense surface irradiance and CO2 limitation.

    • Dongyan Liu
    • , Qian Ma
    • , Ivan Valiela
    • , Donald M. Anderson
    • , John K. Keesing
    • , Kunshan Gao
    • , Yu Zhen
    • , Xiyan Sun
    •  & Yujue Wang
  • Article
    | Open Access

    Using TET2- and ascorbic acid deficient model systems Guan et al show that long term treatment with ascorbic acid delays myeloid neoplasia in mice and reveal a complex interplay of post-translational modification of lysine residues that modulate TET2 activity in neoplastic evolution.

    • Yihong Guan
    • , Edward F. Greenberg
    • , Metis Hasipek
    • , Shi Chen
    • , Xiaochen Liu
    • , Cassandra M. Kerr
    • , Daniel Gackowski
    • , Ewelina Zarakowska
    • , Tomas Radivoyevitch
    • , Xiaorong Gu
    • , Belinda Willard
    • , Valeria Visconte
    • , Hideki Makishima
    • , Aziz Nazha
    • , Mridul Mukherji
    • , Mikkael A. Sekeres
    • , Yogen Saunthararajah
    • , Ryszard Oliński
    • , Mingjiang Xu
    • , Jaroslaw P. Maciejewski
    •  & Babal K. Jha
  • Article
    | Open Access

    Andrews et al. sequenced and assembled the genome of a wireworm, or click beetle (Limonius californicus), an agricultural pest. Their data suggest the presence of multiple genetically distinct cryptic species in addition to population structure and a local adaptive response to pesticide use.

    • Kimberly R. Andrews
    • , Alida Gerritsen
    • , Arash Rashed
    • , David W. Crowder
    • , Silvia I. Rondon
    • , Willem G. van Herk
    • , Robert Vernon
    • , Kevin W. Wanner
    • , Cathy M. Wilson
    • , Daniel D. New
    • , Matthew W. Fagnan
    • , Paul A. Hohenlohe
    •  & Samuel S. Hunter
  • Article
    | Open Access

    Naitow et al. report the structure of a picorna-like plant virus, apple latent spherical virus at 2.87 Å resolution by single particle cryo-EM. The cryo-EM map reveals unique structures that stabilize the capsid frame, and images reveal genome leakage from the protrusion of subunits, giving insight into the proliferation of this virus.

    • Hisashi Naitow
    • , Tasuku Hamaguchi
    • , Saori Maki-Yonekura
    • , Masamichi Isogai
    • , Nobuyuki Yoshikawa
    •  & Koji Yonekura
  • Article
    | Open Access

    Richard Bethlehem et al. identify a subgroup of autism spectrum disorders (ASD) individuals with highly age-atypical cortical thickness using a normative modelling approach across a large cohort. This work highlights the importance of individualized approaches to gain insight into ASD heterogeneity.

    • Richard A. I. Bethlehem
    • , Jakob Seidlitz
    • , Rafael Romero-Garcia
    • , Stavros Trakoshis
    • , Guillaume Dumas
    •  & Michael V. Lombardo
  • Article
    | Open Access

    Ryogo Furuhata, Yasuaki Kabe et al. discover that PGRMC1 is required for adipogenesis in mice and its expression is increased by insulin or PPARγ agonists. They find that knocking out PGRMC1 protects against diet-induced obesity by regulating lipid uptake and accumulation.

    • Ryogo Furuhata
    • , Yasuaki Kabe
    • , Ayaka Kanai
    • , Yuki Sugiura
    • , Hitoshi Tsugawa
    • , Eiji Sugiyama
    • , Miwa Hirai
    • , Takehiro Yamamoto
    • , Ikko Koike
    • , Noritada Yoshikawa
    • , Hirotoshi Tanaka
    • , Masahiro Koseki
    • , Jun Nakae
    • , Morio Matsumoto
    • , Masaya Nakamura
    •  & Makoto Suematsu
  • Article
    | Open Access

    Hans Jonsson et al. report the metagenomic reconstruction of the genome of a potentially immune modulatory segmented filamentous bacteria (SFB) from a human ileostomy sample. They demonstrate that the genome clusters closely with SFB genomes from other species. They also detect the unique SFB variant in human faecal metagenomics datasets.

    • Hans Jonsson
    • , Luisa W. Hugerth
    • , John Sundh
    • , Eva Lundin
    •  & Anders F. Andersson
  • Article
    | Open Access

    Stanton et al. determine the minimal selective concentrations for macrolide and fluoroquinolone antibiotics and describe a selective window defined by the minimal increased persistence concentration. These assessments and thresholds allow for better assessment of potential selection for antibiotic resistance and the risks of human exposure and environmental transmission.

    • Isobel C. Stanton
    • , Aimee K. Murray
    • , Lihong Zhang
    • , Jason Snape
    •  & William H. Gaze