Review Articles

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  • A review of the function of the Dystrophic Glycoprotein Complex (DGC) in mechanosignaling provides an overview of the various components of DGC and potential mechanopathogenic mechanisms, particularly as they relate to muscular dystrophy.

    • Darren Graham Samuel Wilson
    • Andrew Tinker
    • Thomas Iskratsch
    Review Article Open Access
  • Kozlowski, Crook, and Ku review current state-of-the-art techniques in culturing and manipulating organoids without the use of EHS-tumor-derived matrix, the most popular of which is Matrigel by Corning. They cover organoid-based applications of different matrix types, ranging from natural sources (decellularized ECM, purified ECM proteins, polysaccharides), synthetic sources (e.g. PEG-based), and recombinant peptide-based systems.

    • Mark T. Kozlowski
    • Christiana J. Crook
    • Hsun Teresa Ku
    Review Article Open Access
  • Zhang et al. describe metrics for evaluating glycaemic variability (GV) in clinical practice and summarize the role and related mechanisms of GV in diabetic neuropathy, including cardiovascular autonomic neuropathy, diabetic peripheral neuropathy and cognitive impairment. They aim to stimulate ideas for the treatment of diabetic neuropathy.

    • Xiaochun Zhang
    • Xue Yang
    • Chunsheng Zhu
    Review Article Open Access
  • Garbarino et al review recent experimental and epidemiological developments regarding immune responses to sleep deprivation and consider the role for the sleep deprivation induced immune changes in increasing the risk for chronic diseases.

    • Sergio Garbarino
    • Paola Lanteri
    • Egeria Scoditti
    Review Article Open Access
  • In this Review, Bhat et al. highlight ways to mine crop haplotypes and apply them for dissecting complex traits and genomics-assisted breeding (GAB) approaches. This Review presents new avenues to discover superior haplotypes and assemble them in targeted manner in crop breeding for faster delivery of high-yielding cultivars with better adaptation to future climates.

    • Javaid Akhter Bhat
    • Deyue Yu
    • Rajeev K. Varshney
    Review Article Open Access
  • Melo, Maasch and de la Fuente-Nunez review the current practices in use of artificial intelligence in the discovery of antibiotics and antimicrobials. They also provide details about the best-practices that should be engaged with during computational drug discovery, including open science and reproducibility.

    • Marcelo C. R. Melo
    • Jacqueline R. M. A. Maasch
    • Cesar de la Fuente-Nunez
    Review Article Open Access
  • In this review Widden and Placzek synthesize studies characterizing the influence that myeloid cell leukemia-1 (MCL1) has on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broader scope that it plays in cellular homeostasis regulation. They discuss which pathways are likely to be impacted by emerging MCL1 inhibitors, as well as highlight non-cancerous disease states that could deploy BH3-mimetics in the future.

    • Hayley Widden
    • William J. Placzek
    Review Article Open Access
  • In this Review, Laura Martinez-Vidal et al. summarize current knowledge of factors affecting extracellular matrix (ECM) remodeling in the context of pathological mechanical changes to tissue properties. They focus on the importance of research on tissue stiffness to the development of diagnostic tools and therapies to treat urological disease.

    • Laura Martinez-Vidal
    • Valentina Murdica
    • Massimo Alfano
    Review Article Open Access
  • Gómez-López and co-authors discuss advances in the development of in vitro and in vivo models for lung squamous cell carcinoma (LUSC) and their role in understanding the cellular and molecular processes driving LUSC development and responses to therapy.

    • Sandra Gómez-López
    • Zoe E. Whiteman
    • Sam M. Janes
    Review Article Open Access
  • In this Review, Petrus-Reurer et al describe the roles of both innate and adaptive immune responses in allogeneic graft rejection, in addition to discuss how such responses are determined by the cellular therapy of interest. They also describe the range of in vitro and in vivo approaches used to examine the immunogenicity of cellular therapies and consider potential confounders and strategies that can be employed to ameliorate immune rejection.

    • Sandra Petrus-Reurer
    • Marco Romano
    • Kourosh Saeb-Parsy
    Review Article Open Access
  • Carrie Breton and colleagues review the literature supporting evidence for transgenerational health effects of environmental exposures by epigenetic mechanisms. This Review summarizes current knowledge based on animal and human cohort studies, and discusses the ethical, legal, and social implications of epigenetic research in humans

    • Carrie V. Breton
    • Remy Landon
    • Rebecca Fry
    Review Article Open Access