Perspectives

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  • Golesorkhi et al. discuss recent literature on intrinsic neural timescales, their potential role in input processing including computational mechanism, and how they relate to mental features, psychiatric disorders and artificial intelligence.

    • Mehrshad Golesorkhi
    • Javier Gomez-Pilar
    • Georg Northoff
    Perspective Open Access
  • In this Perspective, Diane Dickel and colleagues review recent progress and opportunities in applying single-cell sequencing and microfluidics methods to plants. The authors highlight the need for new tools developed with plants in mind, and advocate for the creation of a centralized, open-access database to house plant single-cell data.

    • Benjamin Cole
    • Dominique Bergmann
    • Diane E. Dickel
    Perspective Open Access
  • Soldan and co-authors propose an evolutionary framework for understanding how host control of the microbiota is influenced by artificial selection. They go on to discuss the potential effect of domestication syndrome on the seed microbiome and plant-microbe interactions in the spermosphere.

    • Riccardo Soldan
    • Marco Fusi
    • Gail M. Preston
    Perspective Open Access
  • Simeoni et al discuss how recent structural work has improved our understanding of SARS-CoV-2 Nsp1-mediated translation inhibition and how Nsp1 inhibition could impact host immune responses and suppress viral replication.

    • Matthieu Simeoni
    • Théo Cavinato
    • David Gatfield
    Perspective Open Access
  • Pudewell et al. discuss and advance our understanding of accessory proteins, which are crucial for the RTK-RAS-MAPK signalling cascade. They consider the therapeutic potential of targeting such modulators as an alternative to targeting constituent components of the RTK-RAS-MAPK signalling cascade in the treatment of diseases such as cancer.

    • Silke Pudewell
    • Christoph Wittich
    • Mohammad R. Ahmadian
    Perspective Open Access
  • In this Perspective, Simpson, Pye, and Whitaker discuss recent research identifying structural genomic variants in human cancers with a particular focus on deletions and duplications at genomic fragile sites. They argue that tumours with predominantly fragile site structural variants represent a distinct mutational signature that warrants further research.

    • Benjamin S. Simpson
    • Hayley Pye
    • Hayley C. Whitaker
    Perspective Open Access
  • Mohan, Abdulhalim and Cvelbar investigated the capabilities of different plasmonic-based sensing techniques including the surface plasmon resonance (SPR), localised SPR, surface-enhanced Raman scattering (SERS), surface-enhanced fluorescence (SEF) and surface-enhanced infrared absorption spectroscopy (SEIRA) for the detection of viruses. The presented data will assist in the development of novel and versatile virus biosensors.

    • Anand M. Shrivastav
    • Uroš Cvelbar
    • Ibrahim Abdulhalim
    Perspective Open Access
  • In this Perspective article, Claudio Quilodrán et al. discuss how hybridization should be considered with respect to conservation. They argue hybridization may be useful for species conservation by enhancing the ability of taxa to adapt better to changing environmental conditions or increasing genetic diversity.

    • Claudio S. Quilodrán
    • Juan I. Montoya-Burgos
    • Mathias Currat
    Perspective Open Access
  • Sannigrahi et al. discuss conformational switching that allows proteins to alter their conformation, aiding in pathogenesis by enabling cellular entry of viruses and bacterial toxins. Focussing on fusion domain of the Spike glycoprotein of SARS COV2 virus, they identify similar “switching sequences” present in diverse pathogen derived proteins.

    • Achinta Sannigrahi
    • Nayan De
    • Krishnananda Chattopadhyay
    Perspective Open Access
  • In this Perspective, Bryan Runck and colleagues discuss an often-overlooked consequence of scaling up cover cropping – a cornerstone of sustainable agriculture. Using published seed yield data from common cover crops, they demonstrate the potentially large land use cost and discuss ways for reducing this cost.

    • Bryan C. Runck
    • Colin K. Khoury
    • Michael Kantar
    Perspective Open Access
  • Pastore et al. provide independent evidence that the Alzheimer Aβ peptides could function as antimicrobial peptides based on convincing structural and sequence similarities with viral fusion domains and established antimicrobial peptides. Aβ could dispatch an antimicrobial function through a mechanism that involves membrane pore formation.

    • Annalisa Pastore
    • Francesco Raimondi
    • Piero Andrea Temussi
    Perspective Open Access