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The optogenetic approach sheds light on the diametric roles of ORX neurons in processing itch and pain. The neural circuit of ORX neurons from LH to the PAG region plays a crucial part in this bidirectional modulation of itch and pain processing.
HCMV induces a senescence-associated secretory phenotype (SASP)-like inflammatory response in renal but not retinal cells, potentially driving kidney pathogenesis through an IL-6-dependent senescence loop in neighboring uninfected cells.
A hyperscanning EEG study during natural unscripted dialogues shows that brain response can be predicted from the other speaker’s audio but not from oneself, even when both participants are speaking at the same time.
An fMRI study of English language comprehension suggests that cortical representations of language timescales are organized in the same way during reading and listening.
Glycosyltransferases that build bacterial surface polysaccharides were classified into 17 new CAZy families. A glycan analysis reveals that the enzymes within each family transfer similar sugars even across Gram-negative and Gram-positive bacteria.
An uncharacterized metallo-β-lactamase identified in a multidrug-resistant Chryseobacterium indologenes has an atypical lipobox and is potentially lipidated. It has a high-affinity for β-lactams including the last-resort antibiotics, carbapenems.
Evidence underscores the non-specificity of mitochondrial dye in assessing horizontal mitochondrial transfer, suggesting that alternative approaches should be considered for gaining nuanced insights into intercellular mitochondrial dynamics.
By using a CRISPR/dCas9 biosensor that reads DNA methylation of α-satellite repeats in live cells, we identify a signaling pathway linking the chromatin and transcriptional state of repeats to the integrity of epithelial adherens junctions.
An integrated single-cell workflow for correlative X-ray computed tomography and X-ray scanning fluorescence imaging to reveal both the overall cellular structures and distribution of multiple chemical elements.
Tph1 subset expresses IL21 to show B cell helper function, while Tph2 subset expresses high levels of cytotoxicity-related molecules and low IL21. Tph1 and Tph2 subsets exert distinct immunological functions in the clinical manifestations in SLE.
This study aims to build trust in MHC class I predictors by providing human-interpretable explanations. The explanations were assessed for accuracy, consistency across prediction models, and stability with similar peptides.
This study presents an embryo assessment method based on optical quantitative phase imaging and machine learning. New biomarkers in relation to the health of an embryo are presented.
A resting-state fMRI study in both humans and macaques suggest that the functional connectivity pattern between amygdala nuclei and the medial prefrontal cortex present similarities and differences that may explain differential behavioral adaptation.
Changes in epiblast morphology, cell polarity, and correlating gene expression patterns indicate continuous developmental progression during diapause in the roe deer.
A structural MRI study suggests that regular exercise training induces plasticity in hippocampal subregions also in young adults. Hippocampal plasticity correlates with changes in spatial memory precision.
An in vitro model of upper gastrointestinal digestion approach identifies changes in microbiome composition and microbial metabolites during simulated colonic fermentation, and implicates several Bacteroides species in the process.
Xenopus tropicalis with triple knockout of mitf, prkdc, and il2rg is a colorless immunodeficient animal model. The mitf−/− frog further underscores the vital role of the mitf in the development of melanophores, xanthophores, and granular glands.
scLinear is a simple linear regression model that outperforms complex machine/deep learning approaches in predicting protein abundance at single-cell resolution.