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  • Article
    | Open Access

    Platonov et al. performed intracerebral recordings from twenty-four drug-resistant epilepsy patients during a discrimination task aimed at discerning actions or gender-related information. They showed that the anterior temporal lobe was specifically activated for 100 ms when patients discriminated the gender of the actor on the static frame presented before the videos.

    • Artem Platonov
    • , Pietro Avanzini
    • , Veronica Pelliccia
    • , Giorgio LoRusso
    • , Ivana Sartori
    •  & Guy A. Orban
  • Article
    | Open Access

    Heyes et al. report that the conformational changes of a full-length Synechocystis phytochrome from the red- to the far-red-absorbing states extend to the seconds timescale. Interestingly, while the rapid structural changes are independent of the output domain the slower changes are not, providing useful insights on photosensory-region dynamics.

    • Derren J. Heyes
    • , Samantha J. O. Hardman
    • , Martin N. Pedersen
    • , Joyce Woodhouse
    • , Eugenio De La Mora
    • , Michael Wulff
    • , Martin Weik
    • , Marco Cammarata
    • , Nigel S. Scrutton
    •  & Giorgio Schirò
  • Article
    | Open Access

    Keigo Araki and colleagues show that E2F3d, a previously unidentified isoform of transcription factor E2F3, mediates hypoxia-induced mitophagy in cancer cells. This study discovers another mitophagy receptor that regulates mitochondrial quality control.

    • Keigo Araki
    • , Keiko Kawauchi
    • , Wataru Sugimoto
    • , Daisuke Tsuda
    • , Hiroya Oda
    • , Ryosuke Yoshida
    •  & Kiyoshi Ohtani
  • Article
    | Open Access

    Shishmarev et al. use rapid dissolution dynamic nuclear polarization to monitor glyoxalase activity in a non-invasive manner using nuclear magnetic resonance spectroscopy. They apply their method to monitor and quantify metabolism of methylglyoxal in human red blood cells and mouse tissues.

    • Dmitry Shishmarev
    • , Philip W. Kuchel
    • , Guilhem Pagès
    • , Alan J. Wright
    • , Richard L. Hesketh
    • , Felix Kreis
    •  & Kevin M. Brindle
  • Article
    | Open Access

    Bret Moore et al. from the International Mouse Phenotyping Consortium report the identification of 347 mouse genes that influence ocular phenotypes when knocked out. 75% of the identified genes have not previously been associated with any ocular pathology.

    • Bret A. Moore
    • , Brian C. Leonard
    • , Lionel Sebbag
    • , Sydney G. Edwards
    • , Ann Cooper
    • , Denise M. Imai
    • , Ewan Straiton
    • , Luis Santos
    • , Christopher Reilly
    • , Stephen M. Griffey
    • , Lynette Bower
    • , David Clary
    • , Jeremy Mason
    • , Michel J. Roux
    • , Hamid Meziane
    • , Yann Herault
    • , Anna Swan
    • , Ruairidh King
    • , Piia Keskivali-Bond
    • , Lois Kelsey
    • , Igor Vukobradovic
    • , Dawei Qu
    • , Ruolin Guo
    • , Elisa Tran
    • , Lily Morikawa
    • , Milan Ganguly
    • , Napoleon Law
    • , Xueyuan Shang
    • , Patricia Feugas
    • , Yanchun Wang
    • , Yingchun Zhu
    • , Kyle Duffin
    • , Ayexa Ramirez
    • , Patricia Penton
    • , Valerie Laurin
    • , Shannon Clarke
    • , Qing Lan
    • , Gillian Sleep
    • , Amie Creighton
    • , Elsa Jacob
    • , Ozge Danisment
    • , Joanna Joeng
    • , Marina Gertsenstein
    • , Monica Pereira
    • , Sue MacMaster
    • , Sandra Tondat
    • , Tracy Carroll
    • , Jorge Cabezas
    • , Amit Patel
    • , Jane Hunter
    • , Gregory Clark
    • , Mohammed Bubshait
    • , David Miller
    • , Khondoker Sohel
    • , Alexandr Bezginov
    • , Matthew McKay
    • , Kevin Peterson
    • , Leslie Goodwin
    • , Rachel Urban
    • , Susan Kales
    • , Rob Hallett
    • , Dong Nguyen-Bresinsky
    • , Timothy Leach
    • , Audrie Seluke
    • , Sara Perkins
    • , Amanda Slater
    • , Rick Bedigian
    • , Leah Rae Donahue
    • , Robert Taft
    • , James Denegre
    • , Zachery Seavey
    • , Amelia Willett
    • , Lindsay Bates
    • , Leslie Haynes
    • , Julie Creed
    • , Catherine Witmeyer
    • , Willson Roper
    • , James Clark
    • , Pamela Stanley
    • , Samantha Burrill
    • , Jennifer Ryan
    • , Yuichi Obata
    • , Masaru Tamura
    • , Hideki Kaneda
    • , Tamio Furuse
    • , Kimio Kobayashi
    • , Ikuo Miura
    • , Ikuko Yamada
    • , Hiroshi Masuya
    • , Nobuhiko Tanaka
    • , Shinya Ayabe
    • , Atsushi Yoshiki
    • , Valerie Vancollie
    • , Francesco Chiani
    • , Chiara Di Pietro
    • , Gianfranco Di Segni
    • , Olga Ermakova
    • , Filomena Ferrara
    • , Paolo Fruscoloni
    • , Alessia Gambadoro
    • , Serena Gastaldi
    • , Elisabetta Golini
    • , Gina La Sala
    • , Silvia Mandillo
    • , Daniela Marazziti
    • , Marzia Massimi
    • , Rafaele Matteoni
    • , Tiziana Orsini
    • , Miriam Pasquini
    • , Marcello Raspa
    • , Aline Rauch
    • , Gianfranco Rossi
    • , Nicoletta Rossi
    • , Sabrina Putti
    • , Ferdinando Scavizzi
    • , Giuseppe D. Tocchini-Valentini
    • , Colin McKerlie
    • , Ann M. Flenniken
    • , Lauryl M. J. Nutter
    • , Zorana Berberovic
    • , Celeste Owen
    • , Susan Newbigging
    • , Hibret Adissu
    • , Mohammed Eskandarian
    • , Chih-Wei Hsu
    • , Sowmya Kalaga
    • , Uchechukwu Udensi
    • , Chinwe Asomugha
    • , Ritu Bohat
    • , Juan J. Gallegos
    • , John R. Seavitt
    • , Jason D. Heaney
    • , Arthur L. Beaudet
    • , Mary E. Dickinson
    • , Monica J. Justice
    • , Vivek Philip
    • , Vivek Kumar
    • , Karen L. Svenson
    • , Robert E. Braun
    • , Sara Wells
    • , Heather Cater
    • , Michelle Stewart
    • , Sharon Clementson-Mobbs
    • , Russell Joynson
    • , Xiang Gao
    • , Tomohiro Suzuki
    • , Shigeharu Wakana
    • , Damian Smedley
    • , J. K Seong
    • , Glauco Tocchini-Valentini
    • , Mark Moore
    • , Colin Fletcher
    • , Natasha Karp
    • , Ramiro Ramirez-Solis
    • , Jacqueline K. White
    • , Martin Hrabe de Angelis
    • , Wolfgang Wurst
    • , Sara M. Thomasy
    • , Paul Flicek
    • , Helen Parkinson
    • , Steve D. M. Brown
    • , Terrence F. Meehan
    • , Patsy M. Nishina
    • , Stephen A. Murray
    • , Mark P. Krebs
    • , Ann-Marie Mallon
    • , K. C. Kent Lloyd
    • , Christopher J. Murphy
    •  & Ala Moshiri
  • Article
    | Open Access

    Zhao Zhang, Youqiong Ye et al. present an expression analysis of tRNAs and genes encoding enzymes involved in translation regulation across ~10,000 patients from 31 cancer types in The Cancer Genome Atlas (TCGA). They find that cancer cells may overcome translational bottlenecks by overexpressing rarer tRNAs and other translation factors.

    • Zhao Zhang
    • , Youqiong Ye
    • , Jing Gong
    • , Hang Ruan
    • , Chun-Jie Liu
    • , Yu Xiang
    • , Chunyan Cai
    • , An-Yuan Guo
    • , Jiqiang Ling
    • , Lixia Diao
    • , John N. Weinstein
    •  & Leng Han
  • Article
    | Open Access

    Sophie Richard et al. present a detailed study of the development of the vasculature in the chicken embryo chorioallantoic membrane. They find that the interlacing of arteries and veins arises due to differential hemodynamic resistance acting on the distal and proximal ends of the arteries causing veins to be alternately repelled or attracted.

    • Sophie Richard
    • , Amanda Brun
    • , Antonio Tedesco
    • , Benjamin Gallois
    • , Naoual Taghi
    • , Philippe Dantan
    • , Johanne Seguin
    •  & Vincent Fleury
  • Article
    | Open Access

    Masamichi Hayashi et al. combine high field neuroimaging (7T fMRI) and multivariate pattern analyses to show that the pattern of functional MRI activity in the right parietal lobe can predict the perception of time in individual participants. They find that while time representation is distributed across frontoparietal regions, the right parietal cortex plays a key role.

    • Masamichi J. Hayashi
    • , Wietske van der Zwaag
    • , Domenica Bueti
    •  & Ryota Kanai
  • Article
    | Open Access

    Guifré Torruella et al. present the first transcriptome data of an aphelid species, which multi-gene phylogenomic analyses place as the closest relative of fungi. They are able to infer a free-living-like aphelid proteome and suggest that fungi evolved through the loss of phagotrophy from aphelid-like ancestors.

    • Guifré Torruella
    • , Xavier Grau-Bové
    • , David Moreira
    • , Sergey A. Karpov
    • , John A. Burns
    • , Arnau Sebé-Pedrós
    • , Eckhard Völcker
    •  & Purificación López-García
  • Article
    | Open Access

    Christopher McCrum et al. present a study of reactive gait adaptation in humans using unexpected treadmill accelerations during walking. They find that humans improve their gait stability over a short time period and, at re-exposure one month later, show further stability improvements due to retention and savings.

    • Christopher McCrum
    • , Kiros Karamanidis
    • , Paul Willems
    • , Wiebren Zijlstra
    •  & Kenneth Meijer
  • Article
    | Open Access

    Niewold, Cohen et al. identify Ly6Clo monocytes as a major component of immune cell sequestration in a mouse model of severe malaria. They show that combined immune-modifying particles and anti-malarial drug treatment at the onset of disease signs results in 88% survival of malaria-infected mice.

    • Paula Niewold
    • , Amy Cohen
    • , Caryn van Vreden
    • , Daniel R. Getts
    • , Georges E. Grau
    •  & Nicholas J. C. King
  • Article
    | Open Access

    George Roff et al. report a 74–92% decline in the catch per unit effort and concurrent declines in body size of large coastal apex sharks near Australia over the past five decades. This study highlights shifting baselines of shark populations in coastal shark assemblages, and indicates that shark populations are highly vulnerable to exploitation.

    • George Roff
    • , Christopher J. Brown
    • , Mark A. Priest
    •  & Peter J. Mumby
  • Article
    | Open Access

    Naoko Kogata et al. generated murine mammary progenitor cell lines that form spheres and secrete milk upon hormonal stimulation. Deletion of Sox9 increased the ability of these cells to forms spheres but decreased milk production induced by lactogenic stimuli, consistent with the role of this transcription factor on maintaining the stem cell state.

    • Naoko Kogata
    • , Philip Bland
    • , Mandy Tsang
    • , Erik Oliemuller
    • , Anne Lowe
    •  & Beatrice A. Howard
  • Article
    | Open Access

    Xin He et al. present a characterization of GhHB12, a HD-ZIP family transcription factor expressed in upland cotton axillary buds. They show that GhHB12 regulates flowering time, plant architecture and phase transition via a regulatory module that could be harnessed to improve cotton for mechanical harvesting.

    • Xin He
    • , Tianyi Wang
    • , Zheng Xu
    • , Nian Liu
    • , Lichen Wang
    • , Qin Hu
    • , Xiangyin Luo
    • , Xianlong Zhang
    •  & Longfu Zhu
  • Article
    | Open Access

    Hongnan Cao et al. present the X-ray crystal structure of E. coli dihydrofolate reductase (DHFR) in complex with its reduced substrate, (6s)-5,6,7,8-tetrahydrofolate (FH4). This structure provides the first glimpse of the rate-limiting product release step of the DHFR mechanism and suggests a strategy for designing DHFR-targeting antibiotics.

    • Hongnan Cao
    • , Mu Gao
    • , Hongyi Zhou
    •  & Jeffrey Skolnick
  • Article
    | Open Access

    Nozomi Endo, Waka Ujita et al. present a video-based system for analysing social behaviour of groups of mice. They find that male mice reared in isolation have impaired social proximity in adulthood, but this is partially rescued by cohabitation with socially-reared mice.

    • Nozomi Endo
    • , Waka Ujita
    • , Masaya Fujiwara
    • , Hideaki Miyauchi
    • , Hiroyuki Mishima
    • , Yusuke Makino
    • , Lisa Hashimoto
    • , Hiroshi Oyama
    • , Manabu Makinodan
    • , Mayumi Nishi
    • , Chiharu Tohyama
    •  & Masaki Kakeyama
  • Article
    | Open Access

    Yohei Hayashi et al. present a method for high-speed adherent cell sectioning and purification, along with a label-free and automatic cell processing system. They show that this method is able to section human induced pluripotent stem cells without losing pluripotency and viability.

    • Yohei Hayashi
    • , Junichi Matsumoto
    • , Shohei Kumagai
    • , Kana Morishita
    • , Long Xiang
    • , Yohei Kobori
    • , Seiji Hori
    • , Masami Suzuki
    • , Toshiyuki Kanamori
    • , Kazuhiro Hotta
    •  & Kimio Sumaru
  • Article
    | Open Access

    Joseph Brown et al. use oligothioetheramides (oligo TEAs) to show that multimeric lipid aggregation in Staphylococcus aureus mimetic membranes correlates with the biological activity of oligoTEAs. These results may explain why antimicrobial peptides with identical cationic charge and hydrophobicity show different biological activity.

    • Joseph S. Brown
    • , Zeinab J. Mohamed
    • , Christine M. Artim
    • , Dana N. Thornlow
    • , Joseph F. Hassler
    • , Vincent P. Rigoglioso
    • , Susan Daniel
    •  & Christopher A. Alabi
  • Article
    | Open Access

    Simone Rampelli, Kathrin Guenther, and their colleagues discover correlations between pre-obese children’s low-diverse, dysbiotic microbiome configurations and their unhealthy diets. This study suggests that diet interventions may promote healthy adulthood by modulating the intestinal microbiota.

    • Simone Rampelli
    • , Kathrin Guenther
    • , Silvia Turroni
    • , Maike Wolters
    • , Toomas Veidebaum
    • , Yiannis Kourides
    • , Dénes Molnár
    • , Lauren Lissner
    • , Alfonso Benitez-Paez
    • , Yolanda Sanz
    • , Arno Fraterman
    • , Nathalie Michels
    • , Patrizia Brigidi
    • , Marco Candela
    •  & Wolfgang Ahrens
  • Article
    | Open Access

    Marcelo D. T. Torres et al. turn toxic wasp-derived antimicrobial peptide polybia-CP into a viable antimicrobial with therapeutic activity in a mouse model. This study demonstrates that a physicochemical property-guided rational design strategy can be used to generate peptide antibiotics.

    • Marcelo D. T. Torres
    • , Cibele N. Pedron
    • , Yasutomi Higashikuni
    • , Robin M. Kramer
    • , Marlon H. Cardoso
    • , Karen G. N. Oshiro
    • , Octávio L. Franco
    • , Pedro I. Silva Junior
    • , Fernanda D. Silva
    • , Vani X. Oliveira Junior
    • , Timothy K. Lu
    •  & Cesar de la Fuente-Nunez
  • Article
    | Open Access

    Hongmin Yun et al. show that implanted human stem cells can accurately home to and repair damaged trabecular meshwork tissue in the mouse eye via a chemokine axis defined by CXCR4 and SDF1. The study suggests that stem cells from the trabecular meshwork could be used to refunctionalize the outflow pathway as a treatment for glaucoma.

    • Hongmin Yun
    • , Yiwen Wang
    • , Yi Zhou
    • , Ke Wang
    • , Ming Sun
    • , Donna B. Stolz
    • , Xiaobo Xia
    • , C. Ross Ethier
    •  & Yiqin Du
  • Article
    | Open Access

    Vishal Kapoor et al. identify a population of cells in the lateral prefrontal cortex that exhibits task phase-related activity during a no-report task. This cell population is functionally segregated from the population encoding conscious perception, although the two operate in parallel.

    • Vishal Kapoor
    • , Michel Besserve
    • , Nikos K. Logothetis
    •  & Theofanis I. Panagiotaropoulos
  • Article
    | Open Access

    Laura Arrigoni et al. present RELACS, a method enabling high-throughput ChIP-seq which involves barcoding and processing intact nuclei in the same ChIP reaction. The method is useful for broad cell types and epitopes, robust to experimental conditions, and drastically decreases workload.

    • Laura Arrigoni
    • , Hoor Al-Hasani
    • , Fidel Ramírez
    • , Ilaria Panzeri
    • , Devon Patrick Ryan
    • , Diana Santacruz
    • , Nadia Kress
    • , John Andrew Pospisilik
    • , Ulrike Bönisch
    •  & Thomas Manke
  • Article
    | Open Access

    Gauthier Carnat et al. report the first measurements of the natural sulfur isotopic composition of sea ice from the Antarctic. They find considerable variability between seasons and sea ice horizons, suggesting unique cycling of sulfur metabolites by sea ice microalgae in extreme environments, with important implications for the production of gasses that impact global climate.

    • Gauthier Carnat
    • , Ward Said-Ahmad
    • , François Fripiat
    • , Boris Wittek
    • , Jean-Louis Tison
    • , Christiane Uhlig
    •  & Alon Amrani
  • Article
    | Open Access

    Ben-Nissan et al. present a rapid mass-spectrometry method for characterizing recombinant proteins directly from culture media. They test their method on secreted recombinant proteins from yeast, insect, and human cells, revealing solubility, molecular weight, structure, ligand binding and post-translational modifications.

    • Gili Ben-Nissan
    • , Shay Vimer
    • , Shira Warszawski
    • , Aliza Katz
    • , Meital Yona
    • , Tamar Unger
    • , Yoav Peleg
    • , David Morgenstern
    • , Hadas Cohen-Dvashi
    • , Ron Diskin
    • , Sarel J. Fleishman
    •  & Michal Sharon
  • Article
    | Open Access

    Christine Lansche, Anil Dasanna et al. investigate the dynamic cytoadhesion behavior of erythrocytes infected with malaria parasite using quantitative flow chamber experiments and computer simulations. They find that parasitized erythrocytes have altered adhesion dynamics, mainly due to differences in cell shape, knob density and membrane bending.

    • Christine Lansche
    • , Anil K. Dasanna
    • , Katharina Quadt
    • , Benjamin Fröhlich
    • , Dimitris Missirlis
    • , Marilou Tétard
    • , Benoit Gamain
    • , Bernd Buchholz
    • , Cecilia P. Sanchez
    • , Motomu Tanaka
    • , Ulrich S. Schwarz
    •  & Michael Lanzer
  • Article
    | Open Access

    Wu et al. introduce RollFISH, a method that enables quantification of single-molecule RNA with high specificity and sensitivity by combining smFISH with rolling circle amplification. RollFISH facilitated studying heterogeneity of biomarkers in formalin-fixed and paraffin-embedded breast cancer tissue, demonstrating its clinical application.

    • Chenglin Wu
    • , Michele Simonetti
    • , Carla Rossell
    • , Marco Mignardi
    • , Reza Mirzazadeh
    • , Laura Annaratone
    • , Caterina Marchiò
    • , Anna Sapino
    • , Magda Bienko
    • , Nicola Crosetto
    •  & Mats Nilsson
  • Article
    | Open Access

    Hamed Alborzinia et al. show that Golgi-dispersing compounds trigger iron-dependent oxidative degradation of lipids, inducing a non-apoptotic cell death called ferroptosis. This study provides insight into the role of Golgi apparatus for preventing ferroptotic cell death through its cellular redox control.

    • Hamed Alborzinia
    • , Tatiana I. Ignashkova
    • , Francesca R. Dejure
    • , Mathieu Gendarme
    • , Jannick Theobald
    • , Stefan Wölfl
    • , Ralph K. Lindemann
    •  & Jan H. Reiling
  • Article
    | Open Access

    Veronica Estrada et al. use implantable microconnectors in rats to promote recovery of complete spinal cord injury. They show that the device leads to re-formation of tissue, vascularization and motor axon regeneration resulting in improvement of locomotor behavior lasting at least 5 months.

    • Veronica Estrada
    • , Julia Krebbers
    • , Christian Voss
    • , Nicole Brazda
    • , Heinrich Blazyca
    • , Jennifer Illgen
    • , Klaus Seide
    • , Christian Jürgens
    • , Jörg Müller
    • , Rudolf Martini
    • , Hoc Khiem Trieu
    •  & Hans Werner Müller
  • Article
    | Open Access

    Hang-Hyun Jo et al. derive a mathematical framework for analyzing circadian clock waveforms. Using data from plants and animals, they find that waveforms of clock protein profiles provide important information about the biochemical mechanisms of circadian timekeeping.

    • Hang-Hyun Jo
    • , Yeon Jeong Kim
    • , Jae Kyoung Kim
    • , Mathias Foo
    • , David E. Somers
    •  & Pan-Jun Kim
  • Article
    | Open Access

    Julius Nitsche et al. demonstrate that binding of two calmodulin molecules displaces the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8 to fully activate this Ca2+ pump by relieving the autoinhibition. This work provides structural evidence for the previously proposed bimodular activation mechanism.

    • Julius Nitsche
    • , Inokentijs Josts
    • , Johannes Heidemann
    • , Haydyn D. Mertens
    • , Selma Maric
    • , Martine Moulin
    • , Michael Haertlein
    • , Sebastian Busch
    • , V. Trevor Forsyth
    • , Dmitri I. Svergun
    • , Charlotte Uetrecht
    •  & Henning Tidow
  • Article
    | Open Access

    Genki Kawamura et al. demonstrate that cells are protected against UV stress through cooperative interactions among circadian clock, heat shock response, and a tumor suppression mechanism. This study reports another protective role of circadian clock as an adaptation strategy against cellular stress.

    • Genki Kawamura
    • , Mitsuru Hattori
    • , Ken Takamatsu
    • , Teruyo Tsukada
    • , Yasuharu Ninomiya
    • , Ivor Benjamin
    • , Paolo Sassone-Corsi
    • , Takeaki Ozawa
    •  & Teruya Tamaru
  • Article
    | Open Access

    Xiaoqing Yi et al. report a co-drug delivery micelle system that demonstrates a high therapeutic efficacy for cancer. This system shows a much improved drug load, photostability, and production of reactive oxygen species, compared to traditional photosensitizer-loaded nanoparticles.

    • Xiaoqing Yi
    • , Jun Dai
    • , Yingyan Han
    • , Min Xu
    • , Xiaojin Zhang
    • , Shijie Zhen
    • , Zujin Zhao
    • , Xiaoding Lou
    •  & Fan Xia
  • Article
    | Open Access

    Kadowaki et al. examine species-specific feedbacks that occur within mycorrhizal fungal guilds in the establishment of tree seedling-soil microbiomes. Using reciprocal invasion experiments, they show that the form of symbiotic relationship affects the nature of microbial feedback.

    • Kohmei Kadowaki
    • , Satoshi Yamamoto
    • , Hirotoshi Sato
    • , Akifumi S. Tanabe
    • , Amane Hidaka
    •  & Hirokazu Toju
  • Article
    | Open Access

    Sarah Benhaiem et al. present a model of demographic responses by the spotted hyena to an epidemic of canine distemper virus in 1993–1994.They find that recovery from the outbreak was slow despite initial moderate mortality, and that high-ranking females sped up recovery by increasing the ecological resistance of the population.

    • Sarah Benhaiem
    • , Lucile Marescot
    • , Marion L. East
    • , Stephanie Kramer-Schadt
    • , Olivier Gimenez
    • , Jean-Dominique Lebreton
    •  & Heribert Hofer
  • Article
    | Open Access

    García-Rosales et al. identified three distinct neuronal populations within the auditory cortex of awake Carollia perspicillata bats. These neurons responded to different temporal features of communication calls from conspecifics and synchronized to distinct cortical oscillations, suggesting multiscale temporal representation at a cellular level.

    • Francisco García-Rosales
    • , M. Jerome Beetz
    • , Yuranny Cabral-Calderin
    • , Manfred Kössl
    •  & Julio C. Hechavarria
  • Article
    | Open Access

    Jake Jones et al. show that changes in the metabolism of individual full-thickness skin wounds can be continuously measured in vivo using non-invasive autofluorescence imaging. This study presents endogenous optical biomarkers of chronic wounds, which offer promise in diagnosing impaired wound healing.

    • Jake D. Jones
    • , Hallie E. Ramser
    • , Alan E. Woessner
    •  & Kyle P. Quinn
  • Article
    | Open Access

    Christine Podrini et al. present a comprehensive analysis of Pkd1 mutant mouse cells and kidneys, providing new insight into autosomal dominant polycystic kidney disease (ADPKD). They find that Pkd1 loss leads to profound metabolic changes, including asparagine synthase-driven glutamine anaplerosis.

    • Christine Podrini
    • , Isaline Rowe
    • , Roberto Pagliarini
    • , Ana S. H. Costa
    • , Marco Chiaravalli
    • , Ivano Di Meo
    • , Hyunho Kim
    • , Gianfranco Distefano
    • , Valeria Tiranti
    • , Feng Qian
    • , Diego di Bernardo
    • , Christian Frezza
    •  & Alessandra Boletta
  • Article
    | Open Access

    Yinnan Mu and colleagues present an improved yellow croaker genome, constructed using a hybrid assembly method incorporating long-reads and short-reads. With their improved assembly, the authors found several gene family expansions associated with olfactory detection, detoxification, and innate immunity.

    • Yinnan Mu
    • , Jieying Huo
    • , Yanyun Guan
    • , Dingding Fan
    • , Xiaoqiang Xiao
    • , Jingguang Wei
    • , Qiuhua Li
    • , Pengfei Mu
    • , Jingqun Ao
    •  & Xinhua Chen
  • Article
    | Open Access

    Theodore Kalbfleisch et al. present an improved genome assembly for the domestic horse by combining short- and long-read data, as well as proximity ligation data. They improve contiguity of the assembly by 40-fold, with a 10-fold reduction in gaps.

    • Theodore S. Kalbfleisch
    • , Edward S. Rice
    • , Michael S. DePriest Jr.
    • , Brian P. Walenz
    • , Matthew S. Hestand
    • , Joris R. Vermeesch
    • , Brendan L. O′Connell
    • , Ian T. Fiddes
    • , Alisa O. Vershinina
    • , Nedda F. Saremi
    • , Jessica L. Petersen
    • , Carrie J. Finno
    • , Rebecca R. Bellone
    • , Molly E. McCue
    • , Samantha A. Brooks
    • , Ernest Bailey
    • , Ludovic Orlando
    • , Richard E. Green
    • , Donald C. Miller
    • , Douglas F. Antczak
    •  & James N. MacLeod
  • Article
    | Open Access

    Ghizlane Maarifi et al. demonstrate that a nuclear pore component, RanBP2, SUMOylates the retroviral restriction factor TRIM5α to promote its antiviral activity. This study suggests an unexpected role of the nuclear pore for regulating anti-viral innate immunity.

    • Ghizlane Maarifi
    • , Juliette Fernandez
    • , Débora M. Portilho
    • , Aude Boulay
    • , Jacques Dutrieux
    • , Stéphane Oddos
    • , Gillian Butler-Browne
    • , Sébastien Nisole
    •  & Nathalie J. Arhel
  • Article
    | Open Access

    HaeWon Jung, Tao Liu et al. combine multimodal adaptive optics with indocyanine green angiography to improve imaging of the human eye. This combination allowed visualization of photoreceptors, retinal pigment epithelial cells, and choriocapillaris of the living eye with remarkable resolution.

    • HaeWon Jung
    • , Tao Liu
    • , Jianfei Liu
    • , Laryssa A. Huryn
    •  & Johnny Tam
  • Article
    | Open Access

    Tsion Zewdu Minas et al. find that men carrying an IFNL4 variant that is more common in African Americans and is associated with impaired viral clearance have a higher risk of prostate cancer. Specifically, this risk is increased in IFNL4 variant carriers with more lifetime sexual partners, suggesting a link to impaired clearance of sexually transmitted infections

    • Tsion Zewdu Minas
    • , Wei Tang
    • , Cheryl J. Smith
    • , Olusegun O. Onabajo
    • , Adeola Obajemu
    • , Tiffany H. Dorsey
    • , Symone V. Jordan
    • , Obadi M. Obadi
    • , Bríd M. Ryan
    • , Ludmila Prokunina-Olsson
    • , Christopher A. Loffredo
    •  & Stefan Ambs
  • Article
    | Open Access

    Kelly Chacón et al. report insights into the mechanism of copper transfer between CusF and CusB, which are involved in heavy metal export as a part of bacterial host-defense strategies. Their results indicate fast formation of a complex involving a shared metallosite with ligands derived from each partner, followed by slower intra-complex metal transfer.

    • Kelly N. Chacón
    • , Jonathan Perkins
    • , Zachary Mathe
    • , Katherine Alwan
    • , Ethan N. Ho
    • , Melek N. Ucisik
    • , Kenneth M. Merz
    •  & Ninian J. Blackburn
  • Article
    | Open Access

    Jessica Ericson et al. examine the viability of Antarctic krill when exposed to near-future levels of ocean acidification for one year. These lab-based simulations of future ocean acidification show that adult krill actively maintain their body acid-base balance, enhancing their resilience.

    • Jessica. A. Ericson
    • , Nicole Hellessey
    • , So Kawaguchi
    • , Stephen Nicol
    • , Peter D. Nichols
    • , Nils Hoem
    •  & Patti Virtue
  • Article
    | Open Access

    Hannah Barkley and Anne Cohen and colleagues used bleaching signatures in coral skeletons to examine the Jarvis Island coral community response to multiple El Niño heatwaves. They find the historically productive ecosystem experienced 10 bleaching events in the past 60 years and its recovery provides insights into coral reef resilience under ocean warming.

    • Hannah C. Barkley
    • , Anne L. Cohen
    • , Nathaniel R. Mollica
    • , Russell E. Brainard
    • , Hanny E. Rivera
    • , Thomas M. DeCarlo
    • , George P. Lohmann
    • , Elizabeth J. Drenkard
    • , Alice E. Alpert
    • , Charles W. Young
    • , Bernardo Vargas-Ángel
    • , Kevin C. Lino
    • , Thomas A. Oliver
    • , Kathryn R. Pietro
    •  & Victoria H. Luu
  • Article
    | Open Access

    Okamoto et al. report that APOL1 RNA, but not protein, expressed from chronic kidney disease (CKD)-associated alleles activates protein kinase R, inducing glomerular injury in a mouse model. The secondary structure of APOL1 risk variant RNA acts as a scaffold for protein kinase R, suggesting potential therapeutic strategies for CKD.

    • Koji Okamoto
    • , Jason W. Rausch
    • , Hidefumi Wakashin
    • , Yulong Fu
    • , Joon-Yong Chung
    • , Patrick D. Dummer
    • , Myung K. Shin
    • , Preeti Chandra
    • , Kosuke Suzuki
    • , Shashi Shrivastav
    • , Avi Z. Rosenberg
    • , Stephen M. Hewitt
    • , Patricio E. Ray
    • , Eisei Noiri
    • , Stuart F. J. Le Grice
    • , Maarten Hoek
    • , Zhe Han
    • , Cheryl A. Winkler
    •  & Jeffrey B. Kopp