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A multidisciplinary approach suggests the importance of cellular geometry in modulating calcium signals in breast cancer cells via the PIEZO1 force sensing channel which is also associated with breast cancer cell plasticity.
This study elucidates the mechanism by which reduced lithocholic acid suppresses glucagon-like peptide 1 via farnesoid X receptor activation under high-temperature-and-humidity condition.
SPADE integrates single-cell RNA sequencing, spatial transcriptomics, and histological data to estimate cell type composition, enhancing understanding of cellular dynamics and tumor tissue diversity.
A large comparative genomics study reveals that Serratia marcescens is composed of five main phylogenetic clusters, isolated by genetic barriers but not clearly separated by ecological specialisations. This results provides insights into the bacterial diversification process.
Using HDX-MS and MD simulations, the authors demonstrate that Ca2+ and Na+ binding to specific domains rigidifies specific structural elements of the NCX protein, revealing regulatory modules and molecular mechanisms governing ion transport rates.
For accurate single cell analyses of glucose uptake ex vivo and in vivo, the authors developed a method using glucose transporter-dependent import of clickable sugars, coupled with fluorescent post-labeling and multicolor flow cytometry.
This study demonstrates that co-clustering of the EphB6 receptor tyrosine pseudokinase with its ephrinB1 ligand on neighboring cells promotes formation of intercellular tubules. This stabilizes cell-cell adhesion and reduces cancer cell invasion.
The VP53 protein, which is expressed from RNA2 of broad bean wilt virus 2 (genus Fabavirus, family Secoviridae) through ribosomal leaky scanning, is essential for the successful systemic infection of the virus.
A hair-thin fibre-optic imaging system that can image the mechanical properties of single-cellular and multi-cellular organisms in 3D with sufficient resolution to identify 300 nm structures in the C. elegans cuticle.
Characterization of nuclear and nucleolar dynamics during adipogenic differentiation of human adipose stem cells points to nucleolar remodeling as an active, mechanoregulated mechanism triggered by cytoskeleton rearrangement.
This study investigates interspecies interaction in a synthetic co-culture consisting of the sucrose-secreting cyanobacterium S. elongatus cscB and its sucrose-consuming partner P. putida cscRABY by employing a comprehensive multi-OMICs approach.
Theory predicts that bacteria living under pulsed growth regimes adapt to pulse duration by adopting different strategies ranging from nimble to torpid responders. Physiological responses to pulse duration of soil bacteria fit the predictions.
Epidermal retinol dehydrogenases 2 (SDR16C5) and RDHE2-similar (SDR16C6) are the major retinol dehydrogenases in skin, which regulate hair cycling, hair composition, hair follicle stem cell markers, and circadian clock genes.
In graft rejection, Th17 promotes tertiary lymphoid tissue, neutrophilic infiltration and DSAs. The RORγt inverse agonist TF-S14 inhibits Th17 cytokines, antibody class switching and prolongs allograft survival in sensitized mice.
A study on the palatal region of pterosaurs suggests different bone interpretations and new identification of the palatal openings, pointing out that the maxillopalatine fenestra in pterosaurs is unique within Diapsida.
Glutamate production from aerial nitrogen was achieved at 1 g L−1 by nitrogen-fixing bacteria, expecting aerial nitrogen utilization for future sustainable bioproduction of N-containing compounds.
A proteome-scale analysis of human coding variants reveals constrained sites in thousands of domains. This highlights key structural or functional residues, including pathogenic sites, especially when integrated with evolutionary conservation.
A novel phylum of bacteria widespread in oligotrophic marine sediments are capable of oxidizing nitrite to nitrate and could resolve the apparent abundance mismatch between ammonia- and nitrite-oxidizers.