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The long-read metagenome of rice phyllosphere microbiome shows novel complete chromosomes, plasmids, bacteriophages, and novel bacterial species. Notably one complete chromosome belongs to the difficult-to-culture bacterium CandidatusSaccharibacteria.
Osteoarthritis (OA) affects over 500 million adults worldwide. Signal transducer and activator of transcription 1 can increase complement C3 expression after IL-1β stimulation, and STAT1 inhibition can prevent OA pathogenesis in guinea pigs.
Both PKC phosphorylation and elevated calcium levels are required for TRPM5 activation, the phosphorylation is crucial for channel-evoked currents at physiological membrane potentials.
Mutational analysis of the flagellar export apparatus protein FlhA suggests that the conserved GYXLI motif of FlhA, together with the cytoplasmic ATPase complex, strictly regulate the order of flagellar protein export.
Aerodynamic modeling based on the primitive, early Eocene bat Onychonycteris strongly supports a gliding transition to powered flight in mammals, which is facilitated under the hyperdense atmospheric conditions here inferred for the fossil age.
The promoter PSCBV-YZ2060 cloned from the sugarcane bacilliform virus is shown to be induced by drought in sugarcane and Arabidopsis plants and is a potential alternative promoter for genetic engineering of drought-resistant transgenic crops.
Nutrition shapes animal growth and survival. E. coli-derived vitamin B6 is crucial for reversing developmental arrest in C. elegans fed with probiotic Lactiplantibacillus plantarum, independently of FoxO/DAF-16 activation.
This review introduces the basic principle of fluorescence and two-photon excitation microscopy that is aimed at novice and advanced microscopists highlighting current techniques, trends, and practical guides for live imaging optimization.
Analysis of M3-Gq coupling utilized fulllength proteins and techniques like HDX-MS & NanoBiT assay, revealing potential binding interfaces in the preassembled and agonistactive complexes and critical regions for the complex formation and Gq activation.
Maternal RNA transcription plays an important role in maintaining vasculature in mouse placental development, associated with regulating gene expression, imprinting status and DNA methylation in the Dlk1-Dio3 imprinted domain.
The output of a nanomachine powered by an array of myosin molecules purified from the skeletal muscle is fed to a stochastic model, which provides a self-consistent estimate of all the mechanokinetic parameters of the motor ensemble.
By combining different microscopy techniques, olive leaf surfaces are shown to be chemically heterogeneous due to the occurrence of trichomes which have mixed hydrophilic-hydrophobic areas at the nanoscale level.
A modelling framework characterising the dynamics of Plasmodium vivax lactate dehydrogenase provides estimates of key biological parameters to facilitate the development of improved diagnostic tools for the detection of P. vivax.
A genetic mouse model of lean-NAFLD reveals that male exhibit a more severe hepatic phenotype with increased macrophage infiltration, FGF21 concentration and sustained hypoglycemia associated with cardiac diastolic dysfunction.
The analysis of root fungal, mycorrhizal, and bacterial communities of tree seedlings sampled across elevation gradients reveals strong effects of edaphic factors on microbial communities and interactions between root microbes and seedling growth.
The snake venom toxins responsible for tissue damage, their mechanisms of action and pathological effects are reviewed, together with the search of novel therapeutic alternatives to abrogate their effects
The study of the biomolecular mechanism of action of the isomers trans and cis-[PtI2(ipa)2] (I5 and I6) shows metabolic disruption, ROS generation and senescence. Functionally, I5 reduces tumor growth in vivo without systemic toxicity.
In vivo triple RNA-seq analysis reveals that a biocontrol yeast consumes host nutrients to outcompete a fungal pathogen on apple, while pattern-triggered immunity and effector-triggered immunity are triggered in the host in response to the fungal pathogen only.
Insertional polymorphisms of recent endogenous retrovirus (ERV) lineages across the eastern koala populations reveal high ERV burden and contrasting geographical virus-host interaction patterns.
A laccase was found to act as a key component of environmental sensing in the fungal plant pathogen Sclerotinia sclerotiorum. This study demonstrates the role that this laccase plays in fungal cell wall architecture and virulence on plant tissue.