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This Perspective highlights the fundamental questions in the regeneration process from start to finish and how they might be addressed to facilitate cross-species studies.
In vivo extracellular recordings in pigs reveal that concussion preferentially disrupts the activity of hippocampal interneurons leading to network hyperexcitability, with in silico models implicating altered voltage-gated sodium channel kinetics.
Flavinated succinate dehydrogenase A (SDHA) is found to be responsible for the reduced autofluorescence observed in oral squamous cell carcinoma, and the functional metabolic implication of this observation is investigated.
A study on the computational design of enzymes for plastic (MHET and PET) degradation yielded an efficient dual enzyme degradation system for PET recycling with a substantially increased activity and a near pure concentration of product TPA.
The phosphorus-solubilizing bacteria Bacillus mucilaginosus, Bacillus megaterium, and Pseudomonas fluorescens can improve the growth of Nicotiana benthamiana in lunar regolith simulant by effectively dissociating insoluble inorganic phosphorus.
Simulating high intensity exercise affects aortic compliance and stiffness in mouse aortic segments studied ex vivo, and is dependent on cyclic stretch amplitude, duration and frequency.
A study mapping the tree species richness in Amazonian forests shows that soil type exerts a strong effect on species richness, probably caused by the areas of these forest types. Cumulative water deficit, tree density and temperature seasonality affect species richness at a regional scale.
The use of mathematical modelling and in vitro assays shows that loss of cell-cell adhesion, increased ECM attachment and tissue architecture promote invasion in a model of hereditary diffuse gastric cancer.
Opto-SCIM combines scanning ion conductance microscopy with optogenetic interrogation to study the hetero-cellular interactions between cardiac fibroblasts or myofibroblasts and cardiomyocytes.
Prenatal folic acid excess and vitamin B12 deficiency are shown to adversely influence neurodevelopment in mice by delaying the generation and migration of late born cerebral cortical neurons and diminishing neuronal dendritic arborization.
Earlier spring green-up and its reduced spatial variability is negatively correlated to insect richness and biomass in temperate forests. Through this pathway, climate warming may indirectly contribute to a decline in insect richness and biomass.
An eigenmode-based structural and functional connectivity mapping approach applied to diffusion and functional MRI data reveals decreased structure-function liberality with age across the human lifespan.
This study shows that mutations in the X chromosome gene Asmt cause anxiety and depression-like behavior in female mice. ASMT enhances the neurobehavioral responsiveness to exercise by maintaining the plasticity of the gut microbiota.
A study involving several research models suggests that the function and synaptic localization of proteasomes, intracellular machineries involved in protein degradation, are impaired in the brains affected by Alzheimer’s disease.
Theoretical modeling and experimental tests shed light on the roles of nascent prerRNA, produced by Pol I transcription, in the assembly of the sea-island multi-phase structure in the nucleolus.
Overexpression of proteins involved in the nervonic acid oil production pathway and an endoplasmatic reticulum structure regulator, which increases lipid production leads to the highest nervonic acid production to date.
Using a comparative approach to advance our understanding of working memory from an evolutionary perspective it is shown that corvid working memory has trade-offs between resolution and temporal stability, similar to what has been reported for primates.
The Fic2 enzyme of the pathogen Coxiella burnetii can act as a bifunctional histone modification enzyme, capable of AMPylation (as monomer) and deAMPylation (as dimer) upon DNA binding by a C-terminal helix-turn-helix domain.
An experimental study on the yellow fever mosquito reveals that inadequate nutrition during both the larval and adult stages could mediate their vectorial capacity by compromising key life history traits and antiviral immune response, while boosting vulnerability to dengue infection.
SNHG14 regulates the expression of Mef2c and activates autophagy through miR-493-5p, promoting osteogenic differentiation of BMSCs and consequently alleviating osteoporosis development.