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A global grassland study reveals soil moisture, not local treatments, drives microbial and detritivore activity, highlighting the potential influence of climate change and human interventions on grassland ecosystems.
Multi-domain and complex structure assembly through domain segmentation and single domain modeling algorithms method outperforms existing state-of-the-art approaches.
This study on the dynamics of the bacterial community in ant-built patches during the life cycle of arboreal ant colonies indicates that ecological processes driven by ant behavior and substrate changes shape the bacterial community.
Single-molecule fluorescence identifies how a G protein and constitutively activating mutations impact GPCR conformational equilibria by altering the population of a crucial intermediate state essential for activation.
A non-coding variant upstream of the CDC20 promoter leads to down-regulation of CDC20 expression and up-regulation of a more proliferative and melanocytic transcriptional program that may aid in accelerating tumor growth.
A multimodal study in comatose patients suggests that awakening was paradoxically more probable when EEG fluctuations were predictable and were integrated into a global recovery of every dimension (eye-opening behaviour, clocked control hormones).
The UBR4 UBR box can bind not only to type 1 N-degron, such as arginine, but also to amino acids with aromatic rings belonging to type 2 N-degrons, and this interaction occurs through pi-interactions.
The authors report excessive amounts of modification-mediated errors in Listeria strains during Nanopore sequencing that are due to novel modifications that were untrained in the Nanopore basecalling model. A whole-genome amplification and a reference-based computational methods (Modpolish) can correct these modification-mediated errors without the need for demodification.
A photodynamic therapy with polphylipoprotein (PLP) was conducted using both normal cells and cancer cells originating from the same sources. PLP enables highly effective cancer treatment by employing a unique mechanism of autophagy.
The authors describe a method for generating functional neural spheroids and assembloids for disease modeling and drug discovery by cell aggregation of differentiated human iPSC derived neurons and astrocytes at cell type compositions mimicking specific regions of the human brain.
An in vivo study in guinea pigs suggests that Toxoplasma gondii infects neurons, astroglia and neural stem cells (NPCs) in the fetal brain after its diaplacentar transmission leading to reduced numbers of NPCs and neurons, and microglia activation.
Auditory responses in zebra finches exposed to a novel canary environment show a surprising transient reversal of typical brain lateralization together with improved discrimination of canary vocalizations, thereby suggesting that lateralization is not fixed, but dynamically regulated.
Cryo-EM examination of phycobilisomes from red algae reveal light-induced structural changes and chromophore variations that have limited effects on fluorescence kinetics, providing insight into how photosynthetic organisms adapt to changing light conditions.
Nematodes bioaccumulate contaminants and promote the channeling of heavy metals to higher trophic levels of the food chain. Predators of metazoans display the highest heavy metal concentrations, followed by predators of microbes and microalgal feeders.
An fMRI/MEG study in humans suggesting that semantic information makes a rapid and distinct contribution to visual object recognition that is linked to feedback activity from the anterior temporal lobes to posterior brain regions.
Biologic epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted mice and swine hearts shows an immune cell response that results in an infiltration of M2 macrophages
A population of human cardiac fibroblasts displays features of both mesenchymal and lymphoid origin cells and these cells reside in pulmonary arterial hypertension fibrotic tissue of patients and a rat model.
Researchers establish an immortalized porcine preadipocyte cell strain for cell-cultured fat research and production, which can be cultured extensively. differentiated within 3D bioscaffolds to generate cell-cultured fat, and co-differentiate with muscle precursor cells, producing a pattern similar to real meat.