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Multiscale molecular dynamics simulations reveal rapidly exchanging lipid binding sites on the nicotinic acetylcholine receptor, including sites with high affinity for phosphatidic acid and promiscuous cholesterol sites in inter-α-helix grooves.
A large-scale study in Europe elucidating the contribution of pathogen clade and host species in disease hotspots caused by Ophidiomyces ophidiicola, the pathogen responsible for snake fungal disease.
Pioneering coral probiotics study shows in situ application reshapes the coral microbiome, boosting beneficial bacteria and reducing pathogens without affecting surrounding seawater and sediment microbiomes.
Targeted modifications of NAD(H) pool size reveal NADH FLIM is sensitive to changes in NAD(H) pool size, mimicking the effect of redox alterations. This potentially confounds experiments where changes to both modalities occur, such as with aging.
A study in mice to identify mechanisms through which a mucosal Klebsiella pneumoniae vaccine elicits Th17 tissue resident memory cells in the lungs reveals a major role for IL-1a signaling and highlights the utility of IL-1a as a mucosal adjuvant.
Hypertension, and organ system dysfunctions associated with preeclampsia (PE) result in poor pregnancy outcomes. In the current study, the authors examined molecular pathogenesis of PE with a focus Peroxisome proliferator-activated receptor gamma (PPARγ), lipid metabolism, and ferroptosis in the placenta of PE patients.
Pancreatic cancer-associated fibroblast enhance the expression of sialic acidcontaining glycans, which interact with Siglec7, -9, -10, -15 receptors on myeloid cells, and drive the differentiation to immunosuppressive macrophages.
Analysis of the virus community associated with red algal mats in Yellowstone National Park shows it to be dominated by Megaviricetes, with resident virus lineages being of ancient origin and encoding genomic footprints of adaptation to thermophily.
Molecular changes in neurodegeneration occur much earlier than previously expected. In this study, dynamic molecular network analysis of iPSC differentiation uncovers a temporal pathway from histone to ISG15 with the earliest molecular changes of SCA1.
A genome-wide association study of 57 trace elements measured in up to 6564 Scandinavians, identifies genetic loci associated with blood levels of essential and non-essential trace elements and explores their effects on health outcomes.
A functional genomics approach in patient derived cell lines of Favorable Histology Wilms Tumor identifies suppression of TRIP13 through the nuclear export inhibitor, KPT-330, leads to decreased viability and synergy with doxorubicin.
A Klebsiella pneumoniae peptide enters Streptococcus pneumoniae via its AmiA-AliA/AliB permease reducing pneumococcal growth, adherence to primary human airway epithelial cells, colonization of rat nasopharynx and genetic transformation.
The cytogenetic analysis of gonial cells and meiocytes on Korean loach complex suggest that instant switch between sexual to asexual reproduction in hybrids depend on their ploidy and genome dosage.
A study combining microscopy, metabarcoding and metabolomics, along with predicted functions, to investigate the relationships between sponge microbiomes and metabolomics, characterizing four sponges and their distinctive bio-ecological traits.
The authors present a single-cell atlas of human lung samples comprising 45 cell types, which reveals dynamic transcriptional and phenotypic changes associated with development and aging.
A multimodal MRI study analyzes how signals within brain tumors shape the organization of brain networks and predict surgical outcomes with simple machine learning methods.
Direct visualization of synaptic ribbons in neonatal and juvenile mouse cochlea demonstrates that excitotoxic stimulus or noise exposure induces increases in ribbon volume and movement.
A multi-ancestry GWAS meta-analysis of Fuchs endothelial corneal dystrophy identifies eight novel loci, including low-frequency missense variants in laminin genes LAMA5 and LAMB1, and phenome-wide scans uncover pleiotropy with renal traits at TCF4.
This study examines how different odor-learning tasks affect structural plasticity in the olfactory bulb. Sensory deprivation, simple and complex odor learning tasks differently modify the spine density and morphology, revealing tailored plasticity.
A study in zebrafish indicates that elevated cortisol levels during early life can alter the developmental trajectory of the hypothalamus, inducing short-term precocious development, but leading to failed maturation in the long-term.