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The UBR4 UBR box can bind not only to type 1 N-degron, such as arginine, but also to amino acids with aromatic rings belonging to type 2 N-degrons, and this interaction occurs through pi-interactions.
The authors report excessive amounts of modification-mediated errors in Listeria strains during Nanopore sequencing that are due to novel modifications that were untrained in the Nanopore basecalling model. A whole-genome amplification and a reference-based computational methods (Modpolish) can correct these modification-mediated errors without the need for demodification.
A photodynamic therapy with polphylipoprotein (PLP) was conducted using both normal cells and cancer cells originating from the same sources. PLP enables highly effective cancer treatment by employing a unique mechanism of autophagy.
The authors describe a method for generating functional neural spheroids and assembloids for disease modeling and drug discovery by cell aggregation of differentiated human iPSC derived neurons and astrocytes at cell type compositions mimicking specific regions of the human brain.
An in vivo study in guinea pigs suggests that Toxoplasma gondii infects neurons, astroglia and neural stem cells (NPCs) in the fetal brain after its diaplacentar transmission leading to reduced numbers of NPCs and neurons, and microglia activation.
Auditory responses in zebra finches exposed to a novel canary environment show a surprising transient reversal of typical brain lateralization together with improved discrimination of canary vocalizations, thereby suggesting that lateralization is not fixed, but dynamically regulated.
Cryo-EM examination of phycobilisomes from red algae reveal light-induced structural changes and chromophore variations that have limited effects on fluorescence kinetics, providing insight into how photosynthetic organisms adapt to changing light conditions.
Nematodes bioaccumulate contaminants and promote the channeling of heavy metals to higher trophic levels of the food chain. Predators of metazoans display the highest heavy metal concentrations, followed by predators of microbes and microalgal feeders.
An fMRI/MEG study in humans suggesting that semantic information makes a rapid and distinct contribution to visual object recognition that is linked to feedback activity from the anterior temporal lobes to posterior brain regions.
Biologic epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted mice and swine hearts shows an immune cell response that results in an infiltration of M2 macrophages
A population of human cardiac fibroblasts displays features of both mesenchymal and lymphoid origin cells and these cells reside in pulmonary arterial hypertension fibrotic tissue of patients and a rat model.
Researchers establish an immortalized porcine preadipocyte cell strain for cell-cultured fat research and production, which can be cultured extensively. differentiated within 3D bioscaffolds to generate cell-cultured fat, and co-differentiate with muscle precursor cells, producing a pattern similar to real meat.
This study sheds light on the mechanism of transcription activation by which VirB, a virulence transcription activator in Shigella flexneri, the causative agent of the diarrheal disease shigellosis, uses the ribonucleotide CTP as a cofactor to load at specific DNA sites.
ACO2 activity is associated with the age of onset for Parkinson’s disease (PD), and the PD-related ACO2 A252T variant causes mitochondrial and autophagy dysfunction, leading to behavioral deficits and dopaminergic neuron loss in PD models.
A vgrG database was established, which revealed six widely distributed domain families with similar genetic configurations. These families may be required for the T6SS effector recruitment process.
The authors unveil a scaling relationship between DNA damage, p53-p21 signaling, and proliferation. The analysis reveals unexpected temporal shifts in p53 and p21 dynamics, encoding damage strength and driving proliferation changes.
DMSP potentially serves as a form of cryoprotection for freshwater dinoflagellates during the time of ice melting in Lake Baikal although sulfur content of the lake water is much lower than seawater and algae do not need an osmolyte in freshwater ice.
Evaluation of 17 published functional weighting methods for improving GWAS statistical power demonstrates a tradeoff between high sensitivity and high positive predictive value.
A chromosome-level genome assembly for Angelica sinensis var. Qinggui1 combined with metabolomic and transcriptomic analyses provides insight into the pathways involved in the biosynthesis of pharmaceutically important compounds in roots of this plant.