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TDP-43 acts as an RNA-binding protein that regulates the RNA stability of ABHD2 and affects the release of fatty acids and ROS, which in turn regulates apoptosis and affects the growth of liver tumors.
Visualisation of spermathecal secretory cell (SSC) secretion in Drosophila reveals that the SSC produces extracellular vesicles to modulate and coordinate reproductive tract activity.
NMR experiments reveal distinct interactions of the histone chaperone, FACT, with the proximal and distal flexible histone H2A and H2B tails of the asymmetrically unwrapped nucleosome.
The co-crystal berberine-ibuprofen is an effective agent for treating obesity through a reduction of the activity of the non-canonical I κB kinases, IKKε and TBK1.
The Staphylococcal superantigen like protein 10 induces necroptosis in human cells through binding to TNFR1 by both the N- and C-terminal domains and activating RIPK1-RIPK3-MLKL and RIPK3-CaMKII-mitochondrial permeability transition pore pathways.
Human alveolar and tracheobronchial epithelial air liquid interface (ALI) tissues are used as models to examine cellular responses to SARS-CoV-2 and influenza A virus infections and as antiviral drug screening assay platforms.
Two factors can drive learning: punishment of failures and reward of successes. Serotonin induces a valence-dependent learning asymmetry, as revealed by prolonged administering of SSRIs to healthy participants in a gambling task.
Compound-testing in a murine model for COVID-19 show that the prophylactic or therapeutic application of Apilimod and other PIKfyve inhibitors, the former being considered for human Phase II trials, worsens disease outcome with higher lung viral load and mortality.
Three natural phenolic compounds are found to bind to an allosteric site in SARS-CoV-2 papain-like protease and exhibit antiviral activity in vitro, showing potential as starting scaffolds for drug design.
GAWMerge is a computational tool that allows users to integrate SNP genotyping data from array techniques or whole-genome sequencing, providing a feasible method to leverage existing cohorts to increase sample size in genetic studies.
Multimodal PET-fMRI imaging of Alzheimer’s disease patients and healthy controls suggests that microglia activation in the posterior cingulate cortex is associated with increased brain activity in Alzheimer’s disease, and independent of amyloid accumulation.
Use of transcranial magnetic stimulation in macaques reveals a potential role for Brodmann area 46d (BA46d) in supporting metacognition, or the ability to be aware of one’s own thoughts.
C-terminal truncation of a-syn results in a more extended and exposed conformation, providing further insight into the pathological role of this truncation event in the progression of Parkinson’s disease.
The crystal structure of the Bacillus thuringiensis protein Cry78Aa shows it consists of a C-terminal β-pore forming domain and an N-terminal trefoil domain and suggests a mechanism underlying the function of Cry78Aa against rice planthoppers.
Using phylogenetic path modelling, geographic isolation is revealed to be the main driver of Nearctic aphid speciation, with subsequent host-use divergence raising the limits on clade species richness.