Leishmania major alters host copper dynamics. Macrophages utilize copper via ATP7A to stress the pathogen, countered by Leishmania that reduces ATP7A and the copper importer CTR1. Infection elevates mouse systemic copper that aids in its defense.

Male humpback whales respond to seismic air gun activity by increasing singing and breeding activity.

Phenotypic profiling using fluorescent probes combined with cell sorting and single-cell derived growth analysis detects differential cultivability and antimicrobial susceptibility in isogenic, but phenotypically heterogenous bacterial populations.

Multi-dimensional analysis of gene expression, myofiber types and metabolic activity in whole skeletal muscle reveals specific regionalization of gene expression and metabolites related to the glycolytic and oxidative potential of myofibers

A landscape genomics analysis of Chinese wild rice identifies signatures of local adaptation in its two lineages and the most maladapted populations under future climate conditions, and provides important clues for its conservation and use.

Uncovering noncanonical trans-cleavage characteristics of Cas12 and Cas13a improves the accuracy of CRISPR-based dual-gene diagnostics and enhances detection sensitivity for single base mismatches through newly discovered activation mechanisms

A novel self-assembled nucleic acid nanostructure-fabricated three-dimensional tumor sphere demonstrates potential for target screening and pharmacodynamic evaluation of CAR-M therapies.

Honeybees communicate the location of flowers through the waggle dance. A method is presented to quantify how much a colony uses the waggle dance when foraging. Waggle dance use varies considerably and is used more in complex landscapes.

KIF1C mediates dynein-driven retrograde transport of lysosomes by interacting with Hook3 and RUFY3, independent of its motor activity. This ensures perinuclear lysosomal positioning, essential for efficient autophagic and endocytic degradation.

Electrophysiological recordings in marmoset ACC area 32 reveal that nearly half of the neurons respond to conspecific vocalizations and complex sounds. Responses show an initial non-selective reduction in activity, followed by sound-selective increases.

Light scattering, resulting from refractive index mismatch, is the primary factor limiting imaging depth in biological tissue. In a study recently published in Science¹, Ou et al. took an unconventional approach and employed highly absorbing molecules, such as food dye tartrazine, to increase the refractive index of water in the near-infrared wavelength range, which rendered tissue transparent in live mice.

Dr. Guifen Liu, now an Associate Professor at ZhangLab, Tongji University, began her research in epigenetic regulation using zebrafish as a model, first as a postdoctoral researcher and then as a research scientist. She established the zebrafish culturing system at the Department of Informatics, Tongji University, Shanghai, China. Dr. Qi Wang is an Assistant Professor at ZhangLab, Tongji University, and she is in charge of the cell culture part of the lab and has broad expertise in high-throughput experimental research on chromatin structure. They are the only two experimental biologists in a dry lab focusing on different research topics. At present, they are in the transition period from experimental scientists to computational scientists. Current Lab Members-Yong Zhang Lab (tongji.edu.cn).

In this Q&A, Brianna Bibel, also known as the Bumbling Biochemist, talks to the journal about how social media can be harnessed to relay scientific information to other researchers, while making it fun and accessible.

Conducting research at the interface of chemistry, microbiology and marine biology, Constanze Kuhlisch reports on challenges in science due to COVID and the situation in Israel, while preparing grants to start her own research group.

Embracing the underlying principles and processes of informed proxy consent or relational autonomy consent in human ancient DNA research can transform research.