Modifying an E2 ubiquitin-conjugating enzyme with a binding domain creates an encodable strategy for driving targeted protein degradation within eukaryotic cells.

The authors performed a GWAS for pelvic organ prolapse (POP) in Japanese women, and identified WT1 as a susceptibility locus for POP in Japanese women. Transethnic GWAS meta-analysis further identified FGFR2 as an additional susceptibility locus for POP.

Phylogenomic analysis and TIRF microscopy were used to investigate the role of actin and myosin in diatom gliding. The findings support the involvement of three raphid diatom-specific myosins in force generation during cell movement.

Exploring virtual pharmacological treatments using whole-brain models and deep learning reveals improvements in disorders of consciousness models when stimulating serotonergic and opioid receptors.

Systematic identification and comparison of biosynthetic gene clusters among Termitomyces species provides insight into their evolutionary history and potential functions of BGCs and the chemicals synthesized by these pathways.

Antimicrobial peptides with membrane-induced structure generate diffusion potential across the E. coli cytosolic membrane at subinhibitory concentrations. The differential ion permeability generates bacterial hyperpolarization.

Multi-dimensional analysis of gene expression, myofiber types and metabolic activity in whole skeletal muscle reveals specific regionalization of gene expression and metabolites related to the glycolytic and oxidative potential of myofibers

A circulating miRNA signature linked to birth defect risk, (i.e. as small-for-gestational-age (SGA) fetuses), was identified for females exposed to the space environment. AI/ML tools were used to predict potential countermeasures to mitigate this risk. @AfshinBeheshti @PittTweet

Copy number variations identified in families with childhood apraxia of speech and other speech sound disorders provide a deeper understanding of the genetic basis for naturally acquired speech.

In mouse keratinocytes, upregulation of PI3Kβ by red light promotes p-STAT3 and accelerates skin wound healing, whereas ROS induced by blue light inhibits p-STAT3 and alleviates scar formation.

In this Q&A, Brianna Bibel, also known as the Bumbling Biochemist, talks to the journal about how social media can be harnessed to relay scientific information to other researchers, while making it fun and accessible.

Conducting research at the interface of chemistry, microbiology and marine biology, Constanze Kuhlisch reports on challenges in science due to COVID and the situation in Israel, while preparing grants to start her own research group.

Embracing the underlying principles and processes of informed proxy consent or relational autonomy consent in human ancient DNA research can transform research.

This comment reports on work done at Harvard Medical School to identify areas for improvement in research rigor, reproducibility, and responsibility in pursuit of continued research excellence.

Documentation of women’s inclusion in Indian academia and conferences by BiasWatchIndia reveals the scale of underrepresentation of women across science, technology, engineering and mathematics.