An fMRI/MEG study in humans suggesting that semantic information makes a rapid and distinct contribution to visual object recognition that is linked to feedback activity from the anterior temporal lobes to posterior brain regions.

The authors unveil a scaling relationship between DNA damage, p53-p21 signaling, and proliferation. The analysis reveals unexpected temporal shifts in p53 and p21 dynamics, encoding damage strength and driving proliferation changes.

Multi-domain and complex structure assembly through domain segmentation and single domain modeling algorithms method outperforms existing state-of-the-art approaches.

The authors describe a method for generating functional neural spheroids and assembloids for disease modeling and drug discovery by cell aggregation of differentiated human iPSC derived neurons and astrocytes at cell type compositions mimicking specific regions of the human brain.

An insect assemblage gathered from the Chorrillo Formation in Argentina constitutes an important set of insect body fossils for the Maastrichtian interval in the Southern Hemisphere.

Comprehensive characterization of the glucose-6-phosphate dehydrogenase (G6PD) Meyer variant that contains an R219G substitution suggests compromised dimerization, stability, and catalytic activity of the mutant enzyme causes chronic hemolysis.

A scRNA-seq study reveals the dynamic landscape of the intestinal cellular microenvironment during radiation-induced intestine injury and regeneration.

A combination of slice physiology, in vivo optogenetics, and behavioral analyses shows that the cortical-cortical connection between bilateral anterior cingulate cortex facilitates pain perception and enhanced anxiety-like behaviors associated with acute and chronic pain in adult mice.

Long-read sequencing of fish and plant samples demonstrate that ethanol suitably preserves field-collected specimens for genome assembly of organisms, reducing the necessity for cryogenic storage.

An integrated approach using phylogeographic data, climate modelling, and network analysis unlocks insights into the post-glacial expansion of the sand fly Phlebotomus mascittii in Europe and suggests two potential (parallel) dispersal routes.

Analysis of the association between Altmetric scores and the gender of first and last authors of articles published in top cardiovascular research journals shows that women receive on average less attention for their work.

Dr. Chris Wallace is a Wellcome Trust Senior Research Fellow, Director of Research, and Principal Investigator in the Department of Medicine and a Programme Leader in the MRC Biostatistics Unit (BSU) at the University of Cambridge. Dr. Guillermo Reales is a postdoctoral researcher in Dr. Wallace’s group, where he recently co-authored a Comment evaluating the impact of sharing summary statistics on average citation rates of genome-wide association studies (GWASs). In this Q&A, we discussed the inspiration for their recent analysis on GWAS summary statistics, the importance of open data, and potential barriers or paths to data sharing in genomics.

Although liquid-liquid phase separation (LLPS) has been extensively studied in various cellular and organismal contexts, the link between functional influence of a genetic mutation and LLPS with respect to human diseases is poorly understood. A recent article by Mensah et al. looks at a rare genetic disease to identify a frameshift mutation, which triggered aberrant phase separation and nucleolar dysregulation, linking genetic variants to a dysregulation of biomolecular condensates.

March 31st marks Transgender Day of Visibility, an opportunity to celebrate and elevate the achievements of the transgender community. As part of our annual celebration of Transgender Day of Visibility, we reached out to Leland Graber and Dr. Ezra Kottler, two early-career transgender biologists who shared their own experiences and perspectives on improving support systems for the transgender research community.

We present a checklist to improve the reliability and reproducibility of molecular dynamics simulations and related methods.

Although we have come a long way in breaking down the stigma surrounding mental health conditions, we still have a long way to go. Here we speak to Dr Anna Schueth - a postdoc and passionate advocate whose blogs and other efforts are leading the way in changing academia towards a direction that will allow everyone to thrive as their authentic selves and to get the support they need.