A study on the evolution of the oxytocin system illustrates the varied role of this neuropeptide in physiology and behavior

A chromosome-level genome assembly for the amphibious plant Rorippa aquatica uncovers its tetraploid origin and an involvement of ethylene in heterophylly upon submergence.

Reversible non-covalent interaction between a bacterial phytochrome-derived fluorescent protein and its biliverdin chromophore enables near-infrared localization nanoscopy in mammalian cells.

This study maps the peripheral immune landscape of childhood Sjogren’s disease at single-cell level, providing immune and molecular characterizations that necessitate a better understanding in the etiology of the rare autoimmune disease.

A phase-contrast CT study of obstructive biliary disease suggests that the evolution of bile infarct and the formation of infarct-sinusoidal microchannels promote the disease progression.

This study reports the direct detection of ribonucleotides embedded in DNA molecules by Oxford Nanopore sequencing, based on ribonucleotides-induced alterations in basecalling features, currents, and dwell times.

Epileptic seizure is one of the symptoms in patients with NGLY1 deficiency, a congenital disorder of deglycosylation. Here the authors show suppressive effects of oxytocin on seizure-like behaviors in a mouse model of NGLY1 deficiency.

PAV-104, a small molecule, potently inhibits SARS-CoV-2 replication in human airway epithelial cells by disrupting viral particle assembly and release. These findings suggest that PAV-104 holds significant promise as a therapeutic for COVID-19.

This study, utilizing deep learning to model semantic saturation, shows its tie to repetitive visual stimuli processing by the primary visual cortex, suggesting a bottom-up neurocognitive process.

The FDA-approved drug disulfiram can inhibit B cells and infiltration of macrophages in a mouse model of heart transplantation.

Documentation of women’s inclusion in Indian academia and conferences by BiasWatchIndia reveals the scale of underrepresentation of women across science, technology, engineering and mathematics.

In 2023, we conducted a virtual program to introduce early-career researchers to the fundamentals of academic journal editing. Here, we reflect on the mission of this program and its outcomes.

A comment article summarizing a range of research activities that contribute to understanding evolving Māori perspectives on Gene Editing and how they might contribute to future regulation.

Nanoparticle therapy continues to be an attractive avenue of targeted and personalised therapies. A molecular nano-conjugate developed by Zeng et al. effectively targets cancer cells and aids in their diagnosis, therapy, and also optimises innate immune responses.

Despite ample investigation on cis-regulatory alterations in evolution, the contribution of these effects to environmental adaptation is poorly understood. Ballinger and colleagues dissected the cis- and trans-regulatory impact on gene expression associated with the adaptation of house mice to temperate and tropical climates, highlighting potential mechanisms acting at a short evolutionary timescale.

The physical properties of the cells and proteins surrounding a tumor play a crucial role in determining the spread of the cancer. How they change cancer cells to suppress the immune response against them is an interesting question addressed in a recent study from Liu et al., which describes how increased stiffness of the tissue around the tumor decreases the amount of a protein—cyclic GMP-AMP synthase—in cancer cells, ultimately blocking the immune response to cancer.