A mechanism study revealing that a sRNA, processed from 3’ UTR of ply operon, responses to O₂ and represses Ply translation post-transcriptionally, ensuring appropriate Ply protein levels in anoxic niches and promoting pneumococcal brain invasion.

Proteomics experiments, metabolomics analyses and network pharmacology combined with molecular biology results suggest that alkaloids of Aconiti Lateralis Radix Praeparata might treat NSCLC by regulating PI3K/Akt-mTOR signaling and glycolysis.

fMRI-neurofeedback targeting a hallucination-related whole-brain network allows individuals to willfully control its temporal properties and modify proneness the hallucination induction, showing promise for investigating future therapies in disease.

Germination of an ancient seed from the Judean desert, confirmed by DNA sequencing and phylogenetic analysis as belonging to an unknown Commiphora sp., contained abundant bioactive compounds, suggesting identification with a resin-producing tree mentioned in Biblical sources.

The immunodominant surface antigen GP60 undergoes dynamic changes in expression profile and localization during parasite invasion and development and is a key molecule mediating host infectivity and pathogenicity.

Exploring virtual pharmacological treatments using whole-brain models and deep learning reveals improvements in disorders of consciousness models when stimulating serotonergic and opioid receptors.

Modifying an E2 ubiquitin-conjugating enzyme with a binding domain creates an encodable strategy for driving targeted protein degradation within eukaryotic cells.

The functional connectivity patterns in cocaine use disorder and their spatial link to neurotransmitter receptor densities are characterized. Findings suggest dopamine D_2/3 receptor densities may underlie the functional architecture of cocaine use.

Analysis of human microglia across health and disease identifies key gene sets in neurodegeneration, offering insights into their role in CNS disorders.

CTBP1 in granulosa cells of PCOS patients represses transcription of aromatase CYP19A1 and regulates stability of SREBP1a, which both contributes to dysregulation of hormone synthesis and lipid metabolism.

In this Q&A, Brianna Bibel, also known as the Bumbling Biochemist, talks to the journal about how social media can be harnessed to relay scientific information to other researchers, while making it fun and accessible.

Conducting research at the interface of chemistry, microbiology and marine biology, Constanze Kuhlisch reports on challenges in science due to COVID and the situation in Israel, while preparing grants to start her own research group.

Embracing the underlying principles and processes of informed proxy consent or relational autonomy consent in human ancient DNA research can transform research.

This comment reports on work done at Harvard Medical School to identify areas for improvement in research rigor, reproducibility, and responsibility in pursuit of continued research excellence.

Documentation of women’s inclusion in Indian academia and conferences by BiasWatchIndia reveals the scale of underrepresentation of women across science, technology, engineering and mathematics.