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Pathogen spread in the puma

Latest Research

  • Article
    | Open Access

    Raddatz, Lyko and colleagues use whole-genome bisulfite sequencing data to generate a methylation clock for chicken. This clock was able to detect age acceleration in broiler chickens under experimentally induced inflammation.

    • Günter Raddatz
    • , Ryan J. Arsenault
    • , Bridget Aylward
    • , Rose Whelan
    • , Florian Böhl
    •  & Frank Lyko
  • Article
    | Open Access

    Clare Gray et al. construct multilayer networks of weed seed regulation and pest gastropod predation by carabid beetles in 374 agricultural fields and show that these ecosystem services are mediated by trophic interaction frequencies. This study reveals that ecosystem services are governed by ecological plasticity in structurally complex, multi-layer trophic networks and these could assist in the assessment of the contribution of biodiversity to ecosystem services.

    • Clare Gray
    • , Athen Ma
    • , Orla McLaughlin
    • , Sandrine Petit
    • , Guy Woodward
    •  & David A. Bohan
  • Article
    | Open Access

    Olena Maiakovska et al. provide whole-genome sequencing of the parthenogenetic and invasive marbled crayfish and develop a computational framework for data analysis of monoclonal genomes. These data and methodology allow the authors to demonstrate genetic separation between two populations and provide the first size estimate for a marbled crayfish colony, which they used to model population growth patterns.

    • Olena Maiakovska
    • , Ranja Andriantsoa
    • , Sina Tönges
    • , Carine Legrand
    • , Julian Gutekunst
    • , Katharina Hanna
    • , Lucian Pârvulescu
    • , Roman Novitsky
    • , András Weiperth
    • , Arnold Sciberras
    • , Alan Deidun
    • , Fabio Ercoli
    • , Antonin Kouba
    •  & Frank Lyko
  • Perspective
    | Open Access

    Mohan, Abdulhalim and Cvelbar investigated the capabilities of different plasmonic-based sensing techniques including the surface plasmon resonance (SPR), localised SPR, surface-enhanced Raman scattering (SERS), surface-enhanced fluorescence (SEF) and surface-enhanced infrared absorption spectroscopy (SEIRA) for the detection of viruses. The presented data will assist in the development of novel and versatile virus biosensors.

    • Anand M. Shrivastav
    • , Uroš Cvelbar
    •  & Ibrahim Abdulhalim
  • Article
    | Open Access

    Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.

    • Lennart Lenk
    • , Michela Carlet
    • , Fotini Vogiatzi
    • , Lea Spory
    • , Dorothee Winterberg
    • , Antony Cousins
    • , Michaela Vossen-Gajcy
    • , Olta Ibruli
    • , Christian Vokuhl
    • , Gunnar Cario
    • , Omar El Ayoubi
    • , Lisa Kramer
    • , Matthias Ritgen
    • , Monika Brüggemann
    • , Robert Häsler
    • , Martin Schrappe
    • , Stephan Fuhrmann
    • , Christina Halsey
    • , Irmela Jeremias
    • , Elias Hobeika
    • , Hassan Jumaa
    • , Ameera Alsadeq
    •  & Denis M. Schewe
  • Article
    | Open Access

    Martins et al. examine the effects of different routes of administration of oxytocin on functional connections in the brain of healthy males at rest. They observe local effects in key-hubs of brain’s oxytocin system (i.e. amygdala) as well as wider-spread effects. This demonstrates that oxytocin likely affects human behaviour by modulating multiple levels of brain processing across different systems.

    • Daniel Martins
    • , Ottavia Dipasquale
    •  & Yannis Paloyelis

News & Comment

  • Research Highlight
    | Open Access

    A huge amount of intrigue surrounds the aging process. Senescence—the decreased likelihood of reproduction and the increased chance of mortality—is a hallmark of aging. The reduced ability of senescent cells to maintain protein homeostasis (proteostasis) has been well-established in nematodes but this phenomenon had yet to be directly demonstrated in human cells. Sabath et al. recently provided compelling evidence that proteostasis collapse is indeed intrinsic to human cell senescence, which may have broad implications in the underlying processes of human aging.

    • Karli Montague-Cardoso
  • Q&A
    | Open Access

    Lorin Crawford began his independent career at Brown University School of Public Health with his own lab in the summer of 2017. He is currently a Senior Researcher at Microsoft Research, New England while also keeping his faculty position at Brown University. In this short Q&A he tells us about his research and the effect the pandemic has had on his lab and science. Dr. Crawford also shares some great tips on academic careers and making biostatistics approachable to wider audience and his views on the most exciting application of machine learning.

  • Research Highlight
    | Open Access

    Protein aggregation and phase separation appear to play important roles in diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), but the interplay between different participating molecular events-which may facilitate or inhibit one another-can be difficult to study by conventional ensemble methods. In a recent study, Kevin Rhine and co-workers make use of point mutations to demonstrate the contrasting behaviour of condensates arising from Glycine and Arginine FUS mutants using single molecules fluorescence measurements.

    • Krishnananda Chattopadhyay
  • Editorial
    | Open Access

    Centrosomes are the main microtubule-organizing centers in animal cells, indispensable for cell division and the building of a wide range of cilia, which include sensory and motile cilia. We are now inviting submissions related to the fascinating field of centrosomes, cilia and all of the processes that they are involved in with the aim of highlighting this work in a Special Collection.

    • Tiago J. Dantas
  • Research Highlight
    | Open Access

    The CRISPR-Cas toolbox allows genetic manipulation of cultured cells, plants and animals on the basis of simpler RNA-guided DNA recognition. It has provided breakthrough scientific opportunities to engineer desirable traits, cure genetic diseases and enable point-of-care diagnostics. A recent study by Joseph Bondy-Denomy and colleagues further equips this toolbox to cut larger chunks of DNA from a cell’s genome.

    • Anam Akhtar
  • Research Highlight
    | Open Access

    It doesn’t take much to disrupt our sleep. Whilst we are aware of environmental factors that can disturb our circadian rhythms, the precise mechanisms that control molecular time cues have remained elusive. Beesley and co-workers demonstrate that diseases associated with cytoplasmic crowding affect the sleep-wake cycle. They also pinpoint a precise time-limiting step in the trafficking of the pacemaker protein PERIOD.

    • Karli Montague-Cardoso

Collection

Mechanobiology

Marco Fritzsche

Mechanobiology

Biomechanical factors shape cellular function through influencing the structural integrity, morphology, and dynamics of cells and tissues. Here we present a collection of articles published in Communications Biology that address how mechanical forces affect biology.

Christina Karlsson Rosenthal

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