In human and murine GBM cells, and wildtype murine astrocytes, radiation induces senescence. Overall, female cells are more sensitive to radiation and to p21-induced senescence. This may contribute to the female survival advantage in GBM.

hPSCs model of Maturity Onset Diabetes of the Young caused by mutations in the transcription factor HNF1A (HNF1A-MODY), regulates the expression of genes required for the formation of dense-core insulin granules and calcium-dependent insulin secretion, demonstrating a basis to treat HNF1A-MODY patients with sulfonylureas.

Data Deficient species are more likely to be at extinction risk than previously thought across multiple taxonomic groups.

Co-display of two P. falciparum malaria vaccine antigens (Pfs230D1+ and CSP) on the surface of immunogenic liposomes results in functional immune responses upon immunization of mice and rabbits. Combining both antigens produces immune responses that both block transmission and prevent infection.

The co-crystal berberine-ibuprofen is an effective agent for treating obesity through a reduction of the activity of the non-canonical I κB kinases, IKKε and TBK1.

Human alveolar and tracheobronchial epithelial air liquid interface (ALI) tissues are used as models to examine cellular responses to SARS-CoV-2 and influenza A virus infections and as antiviral drug screening assay platforms.

IL1R1-signaling triggers enteric glia reactivity, resulting in enteric gliosis, macrophage activation and the development of postoperative ileus.

Laser stimulated fluorescence imagery of Psittacosaurus reveals details about ceratopsian skin anatomy and function.

Compound-testing in a murine model for COVID-19 show that the prophylactic or therapeutic application of Apilimod and other PIKfyve inhibitors, the former being considered for human Phase II trials, worsens disease outcome with higher lung viral load and mortality.

The bones of the archosaur eye socket evolve different shapes dependent on feeding habits and body size.

Communications Biology is inviting submissions on the topic of live microscopy – from new tools to emerging techniques, from conventional to advanced light microscopy - with the aim of publishing high-quality research devoted to advance our understanding of biology.

Dr. Lilian C. Kabeche is an Assistant Professor of Molecular Biophysics and Biochemistry at Yale University, USA. She received her PhD from Dartmouth College working on kinetochore-microtubule attachments in Duane Compton’s laboratory, followed by a postdoctoral training on the DNA damage response in Lee Zou’s group at Harvard Medical School. Lilian started her independent career in 2019.

AuthorArranger is a flexible, user-friendly online tool that can automate the first step of formatting a title page for manuscript submission.

Mariam Jamal-Hanjani is the Senior Clinical Lecturer & Group Leader for the Cancer Metastasis Lab at the UCL Cancer Institute and Honorary Consultant in Translational Lung Oncology at UCL Hospital. Mariam is the lead for their PEACE (Posthumous Evaluation of Advanced Cancer Environment) study, which involves people living with incurable cancer donating their bodies for research after they die, so that scientists can learn more about why cancer spreads and how advanced cancer kills.

June is LGBTQIA+ Pride Month in the United States, where part of the Communications Biology team is based. However, we recognize that Pride Month is just one of many opportunities to celebrate the achievements of this community, and remain committed to using our platform as a journal to amplify and honor queer voices year-round.

A case study on an inclusive faculty hiring process at Emory University provides advice for institutions creating their own hiring panels and workflows.